Results 111 to 120 of about 29,946,329 (341)

Dynamic multibody model of a turntable ladder truck considering unloaded outriggers and sensitivity-based parameter identification

open access: yesMathematical and Computer Modelling of Dynamical Systems
Turntable ladders are flexible large-scale manipulators, so an active oscillation damping is highly valuable. Aiming to support the development and parametrization of the controller, a precise dynamic model of the vehicle is desired.
Bernd Müller, Oliver Sawodny
doaj   +1 more source

Repeated interactions in open quantum systems

open access: yes, 2013
Analyzing the dynamics of open quantum systems has a long history in mathematics and physics. Depending on the system at hand, basic physical phenomena that one would like to explain are, for example, convergence to equilibrium, the dynamics of quantum ...
Bruneau, Laurent   +2 more
core   +4 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Applications of system dynamics modelling to support health policy.

open access: yesPublic Health Research & Practice, 2015
INTRODUCTION The value of systems science modelling methods in the health sector is increasingly being recognised. Of particular promise is the potential of these methods to improve operational aspects of healthcare capacity and delivery, analyse policy ...
J. Atkinson   +5 more
semanticscholar   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Transfer Matrix Method for the Analysis of Multiple Natural Frequencies

open access: yesMathematics
Multiple natural frequencies may be encountered when analyzing the essential natural vibration of a symmetric mechanical system or sub-structure system or a system with special parameters.
Jinghong Wang   +5 more
doaj   +1 more source

Disentanglement and Decoherence by Open System Dynamics

open access: yes, 2003
The destruction of quantum interference, decoherence, and the destruction of entanglement both appear to occur under the same circumstances. To address the connection between these two phenomena, we consider the evolution of arbitrary initial states of a
J. J. Halliwell   +4 more
core   +1 more source

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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