Peptide‐based ligand antagonists block a Vibrio cholerae adhesin
FEBS Letters, EarlyView.The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang +9 more
wiley +1 more source
An Approach to Improving the 4DEnVar‐Initialized Deterministic Prediction Skill for Global Weather
Geophysical Research LettersGlobal deterministic numerical weather predictions (DNWPs) initialized from the ensemble mean analysis of four‐dimensional ensemble‐variational (4DEnVar) data assimilation are usually worse than those initialized by four‐dimensional variational (4DVar ...
Shujun Zhu +14 more
doaj +1 more source
Hittite Journal of Science and Engineering, 2018 M achines like air conditioners and refrigerators, which cause significant energy consumption in countries around the world, are widely used in industry and residences.
Mert Sinan Turgut, Mustafa Turhan Çoban
doaj +1 more source
Systematically reviewing the use of participatory methods in energy system modelling and planning literature. [PDF]
MethodsX, 2022 McGookin C, Ó Gallachóir B, Byrne E.
europepmc +1 more source
FEBS Letters, EarlyView.This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley +1 more source
Special Issue "Complex Dynamic System Modelling, Identification and Control". [PDF]
Entropy (Basel), 2022 Zhu Q, Fusco G, Na J, Zhang W, Azar AT.
europepmc +1 more source
Sets and indices in linear programming modelling and their integration with relational data models [PDF]
, 1993 LP models are usually constructed using index sets and data tables which are closely related to the attributes and relations of relational database (RDB) systems. We extend the syntax of MPL, an existing LP modelling language, in order to connect it to a
Kristjansson, B +3 more
core
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Supporting energy system modelling in developing countries: Techno-economic energy dataset for open modelling of decarbonization pathways in Colombia. [PDF]
Data Brief, 2023 Plazas-Niño FA +2 more
europepmc +1 more source
Development and validation of detailed building, plant and controller modelling to demonstrate interactive behaviour of system components [PDF]
, 2009 As plant modelling becomes capable of more complexity and detailed resolution, new opportunities arise for the virtual evaluation of discrete plant components such as flow control and energy conversion devices, and controllers.
Cockroft, Jeremy +5 more
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