Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
PseudospectralNet: Toward Hybrid Atmospheric Models for Climate Simulations
Journal of Advances in Modeling Earth SystemsRecent machine learning (ML) models have shown great success for weather prediction tasks, suggesting that atmospheric dynamics can in principle be learned from data.
Maximilian Gelbrecht +2 more
doaj +1 more source
Open energy system modelling to support the European Green Deal. [PDF]
F1000Res, 2022 Süsser D +3 more
europepmc +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
The technological transformation of the Russian energy sector forced by carbon regulation
Известия высших учебных заведений: Проблемы энергетикиRELEVANCE of the study lies in the assessment of the impact that various carbon regulation instruments stimulating the achievement of national climate goals have on the development scale of different electricity and heat production technologies in Russia.
A. V. Shigina, A. A. Khorshev
doaj +1 more source
Noise-driven bifurcations in a neural field system modelling networks of grid cells. [PDF]
J Math Biol, 2022 Carrillo JA, Holden H, Solem S.
europepmc +1 more source
A Process-Oriented Architecture for Complex System Modelling [PDF]
, 2007 A fine-grained massively-parallel process-oriented model of platelets (potentially artificial) within a blood vessel is presented. This is a CSP inspired design, expressed and implemented using the occam-pi language. It is part of the TUNA pilot study on
Ritson, Carl G., Welch, Peter H.
core
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Applying systems approaches to stakeholder and community engagement and knowledge mobilisation in youth mental health system modelling. [PDF]
Int J Ment Health Syst, 2022 Freebairn L +9 more
europepmc +1 more source
The stochastic nature of stellar population modelling
, 2013 Since the early 1970s, stellar population modelling has been one of the basic tools for understanding the physics of unresolved systems from observation of their integrated light.
Cerviño, Miguel
core +1 more source