Results 61 to 70 of about 143,113 (265)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Existence Theorem for Integral and Functional Integral Equations with Discontinuous Kernels
Abstract and Applied Analysis, 2012 Existence of extremal solutions of nonlinear discontinuous integral equations of Volterra type is proved. This result is extended herein to functional Volterra integral equations (FVIEs) and to a system of discontinuous VIEs as well.
Ezzat R. Hassan
doaj +1 more source
Freezing in Space-time: A functional equation linked with a PDE system [PDF]
, 2022 Krzysztof Burdzy, A. J. Ostaszewski
openalex +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
QQ-system and non-linear integral equations for scattering amplitudes at strong coupling
Journal of High Energy Physics, 2020 We provide the two fundamental sets of functional relations which describe the strong coupling limit in AdS 3 of scattering amplitudes in N $$ \mathcal{N} $$ = 4 SYM dual to Wilson loops (possibly extended by a non-zero twist l): the basic QQ-system and ...
Davide Fioravanti +2 more
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Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Journal of Function Spaces, 2017 We discuss the functional control systems governed by differential equations with Riemann-Liouville fractional derivative in general Banach spaces in the present paper.
Badawi Hamza Elbadawi Ibrahim +2 more
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Advances in Mathematical Physics, 2014 The shifted Jacobi-Gauss collocation (SJGC) scheme is proposed and implemented to solve the fractional neutral functional-differential equations with proportional delays.
A. H. Bhrawy, M. A. Alghamdi
doaj +1 more source