Results 81 to 90 of about 143,113 (265)
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Abstract and Applied Analysis, 2014 The modified generalized Laguerre-Gauss collocation (MGLC) method is applied to obtain an approximate solution of fractional neutral functional-differential equations with proportional delays on the half-line.
Ali H. Bhrawy +3 more
doaj +1 more source
ON POSITIVITY OF SEVERAL COMPONENTS OF SOLUTION VECTOR FOR SYSTEMS OF LINEAR FUNCTIONAL DIFFERENTIAL EQUATIONS [PDF]
, 2009 Ravi P. Agarwal, Alexander Domoshnitsky
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
On the equivalence of pre-Schröder equations [PDF]
Opuscula Mathematica, 2007 In the paper the equivalence of the system of two pre-Schröder functional equations (equations \((S_n)\), \((S_m)\) for \(m \gt n \geq 3\), \(n, m \in \mathbb{N}\)) and the whole system \((S)\), is considered.
Józef Kalinowski
doaj
Convergence of numerical methods for systems of neutral functional-differential-algebraic equations [PDF]
, 1995 Tadeusz Jankowski, M. Kwapisz
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FEBS Open Bio, EarlyView.Representation of the suggested mode of action of lactoferrin (Lf) in nonsmall cell lung cancer (NSCLC) A549 cells. Lf induces activation of caspase‐3 by activating p53 and AChE leading to decreased ACh concentrations. In turn, ACh signaling leads to activation of VEGF and AKT and blocking of caspase‐3.
Stuti Goel +9 more
wiley +1 more source
FEBS Open Bio, EarlyView.CAF‐mediated immunosuppression in ovarian cancer is driven by IDO1, reducing T‐cell function. Inhibiting IDO1 restores T‐cell proliferation and cytotoxicity, increases cancer cell apoptosis, and may help overcome CAF‐induced immune suppression in high‐grade serous ovarian cancer. Targeting IDO1 may improve antitumor immunity.
Hyewon Lee +3 more
wiley +1 more source
A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
A system of functional‐differential equations associated with the optimal detection problem for jump‐times of a Poisson process [PDF]
, 1996 Doncho S. Donchev
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