Results 81 to 90 of about 3,708,184 (376)

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Predominance of Leishmania major and rare occurrence of Leishmania tropica with haplotype variability at the center of Iran

Brazilian Journal of Infectious Diseases, 2018
Background: Leishmania major is a causative agent of zoonotic cutaneous leishmaniasis in the center of Iran, Abarkouh district. Molecular characterization and precise incrimination of Leishmania species was carried out to perform controlling measurements
Amir Hossein Zahirnia, Ali Bordbar, Sahar Ebrahimi, Adel Spotin, Somayeh Mohammadi, Seyedeh Maryam Ghafari, Setareh Ahmadvand, Negar Jabbari, Ahmad Reza Esmaeili Rastaghi, Parviz Parvizi   +9 more
doaj   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Emission-line Stacking of 21 cm Intensity Maps with MeerKLASS: Inference Pipeline and Application to the L-band Deep-field Data

The Astrophysical Journal Supplement Series
We present a novel analysis of observational systematics through the emission-line stacking of the MeerKLASS L -band deep-field intensity maps, following the detection in MeerKLASS Collaboration et al.
Zhaoting Chen, Steven Cunnington, Alkistis Pourtsidou, Laura Wolz, Marta Spinelli, José Luis Bernal, Matilde Barberi-Squarotti, Stefano Camera, Isabella P. Carucci, José Fonseca, Keith Grainge, Melis O. Irfan, Mario G. Santos, Jingying Wang, (MeerKLASS Collaboration)   +14 more
doaj   +1 more source

Phylogeny and evolution of Müllerian mimicry in aposematic Dilophotes: evidence for advergence and size-constraints in evolution of mimetic sexual dimorphism

Scientific Reports, 2018
Multiple patterns and intraspecific polymorphism should not persist in mutualistic Müllerian systems due to purifying and frequency-dependent selection, but they are commonly identified in nature.
Michal Motyka, Lucie Kampova, Ladislav Bocak   +2 more
doaj   +1 more source

Non-Gaussianity and direction dependent systematics in HST key project data

, 2011
Two new statistics, namely $\Delta_\chi^2$ and $\Delta_\chi$, based on extreme value theory, were derived in \cite{gupta08,gupta10}. We use these statistics to study direction dependence in the HST key project data which provides the most precise ...
Gupta, Shashikant, Saini, Tarun Deep
core   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

How animals distribute themselves in space: variable energy landscapes

Frontiers in Zoology, 2017
Background Foraging efficiency determines whether animals will be able to raise healthy broods, maintain their own condition, avoid predators and ultimately increase their fitness. Using accelerometers and GPS loggers, features of the habitat and the way
Juan F. Masello, Akiko Kato, Julia Sommerfeld, Thomas Mattern, Petra Quillfeldt   +4 more
doaj   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source