Results 101 to 110 of about 4,473,110 (337)

Cotargeting TREM2 and IL2 pathways triggers multipronged anticancer immunity

Molecular Oncology, EarlyView.
Von Locquenghien et al. report that MiTE‐144, a triggering receptor expressed on myeloid cells 2 (TREM2) blocking antibody fused to interleukin‐2 (IL2) variant with tumour microenvironment restricted activation, demonstrates superior anticancer efficiency in a preclinical setting.
Isaure Vanmeerbeek, Jenny Sprooten, Abhishek D. Garg   +2 more
wiley   +1 more source

Metabolic Adaptations in Cancer and the Host Using Drosophila Models and Advanced Tools

Cells
Cancer is a multifactorial process involving genetic, epigenetic, physiological, and metabolic changes. The ability of tumours to regulate new reactive pathways is essential for their survival. A key aspect of this involves the decision-making process of
Ernesto Saez-Carrion, Mario Aguilar-Aragon, Lucia García-López, Maria Dominguez, Mary Luz Uribe   +4 more
doaj   +1 more source

Systemic inflammatory markers in COPD: results from the Bergen COPD Cohort Study [PDF]

, 2009
Tomas Eagan, Thor Ueland, Peter D. Wagner, Jon A. Hardie, Tom Eirik Mollnes, J Damås, Pål Aukrust, Per Bakke   +7 more
openalex   +1 more source

Inhibition of IDO leads to IL-6-dependent systemic inflammation in mice when combined with photodynamic therapy [PDF]

, 2020
Małgorzata Wachowska, Joanna Stachura, Katarzyna Tonecka, Klaudyna Fidyt, Agata Braniewska, Zuzanna Sas, Iwona Kotuła, Tomasz P. Rygiel, Louis Boon, Jakub Gołąb, Angelika Muchowicz   +10 more
openalex   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source

Profile of tofacitinib citrate and its potential in the treatment of moderate-to-severe chronic plaque psoriasis

Drug Design, Development and Therapy, 2016
V Di Lernia,1 F Bardazzi2 1Dermatology Unit, Arcispedale Santa Maria Nuova IRCCS, Reggio Emilia, 2Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy Abstract: The outlook for ...
Di Lernia V, Bardazzi F
doaj  

Systemic clearance of p16^INK4a‐positive senescent cells mitigates age‐associated intervertebral disc degeneration [PDF]

, 2019
Prashanti Patil, Qing Dong, Dong Wang, Jianhui Chang, Christopher D. Wiley, Marco Demaria, Joon Lee, James D. Kang, Laura J. Niedernhofer, Paul D. Robbins, Gwendolyn Sowa, Judith Campisi, Daohong Zhou, Nam Vo   +13 more
openalex   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Spatial cycles mediated by UNC119 solubilisation maintain Src family kinases plasma membrane localisation

Nature Communications, 2017
The peripheral membrane proto-oncogene Src family protein tyrosine kinases (SFKs) transmit growth factor signals to the cytoplasm. Here the authors show that the solubilising factor UNC119 sequesters myristoylated SFKs to maintain its enrichment at the ...
Antonios D. Konitsiotis, Lisaweta Roßmannek, Angel Stanoev, Malte Schmick, Philippe I. H. Bastiaens   +4 more
doaj   +1 more source

Dietary nitrate and nitrite protect against doxorubicin‐induced cardiac fibrosis and oxidative protein damage in tumor‐bearing mice

FEBS Open Bio, EarlyView.
Chemotherapies such as doxorubicin can have toxic effects on healthy cardiovascular/heart tissue. Following up on a doxorubicin toxicity study in mice without tumors where nitrate water was cardioprotective (lessened toxicity), this study with tumor‐bearing mice undergoing doxorubicin treatment showed no negative effect of nitrate and nitrite on drug ...
Rama D. Yammani, Xiaofei Chen, Nildris Cruz‐Diaz, Xuewei Zhu, Swati Basu, Daniel B. Kim‐Shapiro, David R. Soto‐Pantoja, Leslie B. Poole   +7 more
wiley   +1 more source