Results 61 to 70 of about 1,840,438 (269)
Revista Científica de Ingeniería Energética, 2012 Los generadores de potencia son de gran importancia para la producción de electricidad. Un fallo en un generador ocasiona la interrupción de su servicio, limitaciones o pérdida total de la energía generada, tiene efectos negativos sobre la economía y ...
Odalys Martínez Rodríguez +1 more
doaj
Transitivité systémique et analyse du texte
La Bretagne Linguistique, 1990 In linguistics, approaches that radically separate syntax and semantics, falling into the trap of impoverishing a richer truth, leave me wanting more and preferring theories that accept their inseparable relationship as a basic fact. One theory that fits
David Banks
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Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Analyse des défis de la filière viande de brousse sur la durabilité faunique au Gabon
VertigOThe bushmeat chain is a source of income-generating activities for its actors, but it is dangerous for the survival of wildlife because of the non-respect of the hunting calendar.
Apolline Medzey Me Sima +2 more
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Safety Analysis of Systems-of-Systems.
, 2022 Safety-critical systems may fail dangerously with severe consequences to the health of the involved humans, costly equipment, the environment, or other valuable assets of a stakeholder. For these classes of systems, the developers are obliged to analyze each potentially hazardous situation thoroughly.
openaire +2 more sources
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
A systemic functional analysis of two multimodal covers
Revista Alicantina de Estudios Ingleses, 2006 Our society is influenced by new texts, which are clearly characterised by the increasing dominance of the visual mode; this implies that new literacies need to be developed as a way of enabling the readers to question the texts they are exposed to.
Martínez Lirola, María
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Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source