Results 81 to 90 of about 1,840,438 (269)

Taking values seriously for transformational climate change adaptation

Climate Risk Management
Climate change is causing extensive and unprecedented impacts on individuals, societies, and ecosystems. Transformational efforts are increasingly advocated to overcome limits to climate change adaptation, but they can entail difficult and potentially ...
Elisa Calliari, Tara Quinn, Michael Klenk, Lovleen Bhullar, Iva Peša, Matthew J. Dennis   +5 more
doaj   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

A systemic analysis of monocarboxylate transporters in ovarian cancer and possible therapeutic interventions. [PDF]

Channels (Austin), 2023
Chatterjee P, Bhowmik D, Roy SS.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

EEG synchronization patterns during a Go/No-Go task in individuals with aphasia in subacute and chronic phases of stroke

Scientific Reports
Stroke and subsequent neuroregenerative processes cause changes in neural organization of attentional functions. In this study, we attempted to identify differences in neural synchronization patterns during a visual Go/No-Go task in people with post ...
Jacek Rogala, Mateusz Choinski, Aneta Szymaszek   +2 more
doaj   +1 more source

Systemic analysis of the expression and prognostic significance of USP31 in endometrial cancer. [PDF]

Biomol Biomed, 2023
Huang Y, Jiang P, Chen Y, Wang J, Yuan R.   +4 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Assessment of Oral Hygiene Behavioral and Demographic Risk Factors for Extrahepatic Manifestations of Hepatitis C

Medical Sciences
Background: Hepatitis C (HC) remains a major public health concern, affecting approximately 50 million people globally. In addition to hepatic damage, HC induces extrahepatic manifestations (EHMs), including oral conditions such as oral lichen planus ...
Mihai Oprea, Andreea Cândea, Alexandra Roman, Ion Rogoveanu, Allma Roxana Pitru, Claudiu Marinel Ionele, Dorin Nicolae Gheorghe, Flavia Mirela Nicolae, Dora Maria Popescu, Adina Turcu-Stiolica, Sergiu Ciobanu, Petra Surlin   +11 more
doaj   +1 more source

Systemic analysis identifying PVT1/DUSP13 axis for microvascular invasion in hepatocellular carcinoma. [PDF]

Cancer Med, 2023
Su R, Zhang H, Zhang L, Khan AR, Zhang X, Wang R, Shao C, Wei X, Xu X.   +8 more
europepmc   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source