Results 1 to 10 of about 384,575 (149)

Understanding the Toxicity Profile of Approved ADCs. [PDF]

Pharmaceutics
Background: Antibody–drug conjugates (ADCs) represent a novel therapeutic class that combines an antibody against a tumor-associated antigen (TAA), a payload, and a linker that binds these two components. Serious adverse events (SAEs), particularly those of grade 3 (G3) or higher, frequently contribute to the abandonment of ADCs during clinical ...
Ballestín P, López de Sá A, Díaz-Tejeiro C, Paniagua-Herranz L, Sanvicente A, López-Cade I, Pérez-Segura P, Alonso-Moreno C, Nieto-Jiménez C, Ocaña A.   +9 more
europepmc   +4 more sources

Toxicity Profile of Combining PD-1/PD-L1 Inhibitors and Thoracic Radiotherapy in Non-Small Cell Lung Cancer: A Systematic Review

Frontiers in Immunology, 2021
BackgroundThe combination of immune checkpoint inhibitors (ICIs) and thoracic radiotherapy (TRT) has shown significant clinical activity in patients with non-small cell lung cancer (NSCLC).
Butuo Li, Chao Jiang, Linlin Pang, Bing Zou, Mingjun Ding, Mingjun Ding, Xindong Sun, Jinming Yu, Linlin Wang   +8 more
doaj   +1 more source

Assessment and bioremediation of mercury pollutants by highly mercury-resistant bacteria immobilized in biochar from small-scale artisanal gold mining areas

Journal of Degraded and Mining Lands Management, 2023
Small-scale gold mining activities in Indonesia still use amalgamation techniques, which have the potential to cause mercury (Hg) pollution and affect the quality and number of microorganisms.
Dewi Nursaidah Rohmah, Endah Retnaningrum   +1 more
doaj   +1 more source

Musculoskeletal adverse events induced by immune checkpoint inhibitors: a large-scale pharmacovigilance study

Frontiers in Pharmacology, 2023
Background: The musculoskeletal toxicity of immune checkpoint inhibitors (ICIs) is receiving increasing attention with clinical experience. Nevertheless, the absence of a systematic investigation into the musculoskeletal toxicity profile of ICIs ...
Hao Liu, Yumin Li, Jie Li, Qiongchi Zhang, Jingtao Wu, Xinyu Li, Liesu Meng, Shuai Cao, Haopeng Li   +8 more
doaj   +1 more source

Ethnobotany and Phytopharmacology of Avena sativa: A Qualitative Review

Sciences of Phytochemistry, 2023
Among all cereals, oat is considered to be one of the goods consumed in functional grain, nutraceutical, and pharmaceutical components. The review article aims to explore plant profile, phytochemical constituents present in different parts, and potential
Shuby Kumari, Sheikh Rezzak Ali, Obaidur Rahman, Amit Kumar, Hans Raj Bhat, Surajit Kumar Ghosh, Anshul Shakya   +6 more
doaj   +1 more source

Review of Functional Aspects of Nanocellulose-Based Pickering Emulsifier for Non-Toxic Application and Its Colloid Stabilization Mechanism

Molecules, 2022
In the past few years, the research on particle-stabilized emulsion (Pickering emulsion) has mainly focused on the usage of inorganic particles with well-defined shapes, narrow size distributions, and chemical tunability of the surfaces such as silica ...
Shao Hui Teo, Ching Yern Chee, Mochamad Zakki Fahmi, Satya Candra Wibawa Sakti, Hwei Voon Lee   +4 more
doaj   +1 more source

Acute Toxicity Profile of Maprotiline in the Rat [PDF]

Pharmacology & Toxicology, 1999
Abstract The aim of the present study was to examine the toxic effects of single oral administrations of the antidepressant maprotiline at 150 mg/kg or 300 mg/kg using female Sprague‐Dawley rats. Body‐weight gain was significantly reduced in the group receiving 300 mg/kg on days 1–5 of the study (P<0.01).
Darcy, Philip, Dredge, Keith, Kellehir, Padraig, Kelly, John P., Leonard, Brian E., Chambers, Philip L.   +5 more
openaire   +2 more sources

Toxicity profile of combined immune checkpoint inhibitors and thoracic radiotherapy in esophageal cancer: A meta-analysis and systematic review

Frontiers in Immunology, 2022
BackgroundTherapies based on the combination of immune checkpoint inhibitors (ICIs) and thoracic radiotherapy (TRT) are transforming the treatment landscape of esophageal cancer.
Tongzhen Xu, Yunsong Liu, Xiaotong Lu, Jun Liang   +3 more
doaj   +1 more source

Cross study analyses of SEND data: toxicity profile classification [PDF]

Toxicological Sciences
Mark A Carfagna, Susan Butler, Tamio Fukushima   +2 more
exaly   +2 more sources

Freshwater Algal Toxins: Monitoring and Toxicity Profile [PDF]

Toxins, 2020
Climate change and human activities are more and more affecting the dynamics of phytoplankton communities [...]
Angeles Jos, Ana M. Cameán
openaire   +5 more sources