Results 11 to 20 of about 384,674 (248)

Development of anin SilicoProfiler for Mitochondrial Toxicity [PDF]

Chemical Research in Toxicology, 2015
This study outlines the analysis of mitochondrial toxicity for a variety of pharmaceutical drugs extracted from Zhang et al. ((2009) Toxicol. In Vitro, 23, 134-140). These chemicals were grouped into categories based upon structural similarity. Subsequently, mechanistic analysis was undertaken for each category to identify the molecular initiating ...
Nelms, Mark, Mellor, Claire, Mark, Cronin, Judith, Madden, Steve, Enoch   +4 more
openaire   +3 more sources

Clinical Safety of Combined Targeted and Viscum album L. Therapy in Oncological Patients

Medicines, 2018
Background: Despite improvement of tumor response rates, targeted therapy may induce toxicities in cancer patients. Recent studies indicate amelioration of adverse events (AEs) by add-on mistletoe (Viscum album L., VA) in standard oncological treatment ...
Anja Thronicke, Shiao Li Oei, Antje Merkle, Harald Matthes, Friedemann Schad   +4 more
doaj   +1 more source

Pesticide Toxicity Profile: Bipyridylium Herbicides

EDIS, 2005
This document provides a general overview of human toxicity, provides a listing of laboratory animal and wildlife toxicities and a cross reference of chemical, common and trade names of the bipyridylium herbicides registered for use in Florida.
Frederick M. Fishel
doaj   +5 more sources

Pesticide Toxicity Profile: Miscellaneous Rodenticides

EDIS, 2005
This document provides a general overview of human toxicity, provides a listing of laboratory animal and wildlife toxicities and a cross reference of chemical, common and trade names of miscellaneous rodenticides registered for use in Florida.
Frederick M. Fishel
doaj   +5 more sources

Pesticide Toxicity Profile: Carbamate Pesticides

EDIS, 2005
This document provides a general overview of human toxicity, provides a listing of laboratory animal and wildlife toxicities and a cross-reference of chemical, common and trade names of many carbamate pesticides registered for use in Florida.
Frederick M. Fishel
doaj   +5 more sources

Toxic metabolite profiling of Inocybe virosa

Scientific Reports, 2020
AbstractWild mushroom foraging involves a high risk of unintentional consumption of poisonous mushrooms which is a serious health concern. This problem arises due to the close morphological resemblances of toxic mushrooms with edible ones. The genus Inocybe comprises both edible and poisonous species and it is therefore important to differentiate them.
S. Sai Latha, Naveen Shivanna, Mahadeva Naika, K. R. Anilakumar, Ankur Kaul, Gaurav Mittal   +5 more
openaire   +2 more sources

Pesticide Toxicity Profile: Chlorophenoxy Herbicides

EDIS, 2005
This document provides a general overview of human toxicity, provides a listing of laboratory animal and wildlife toxicities and a cross reference of chemical, common and trade names of the chlorophenoxy herbicides registered for use in Florida.
Frederick M. Fishel
doaj   +5 more sources

4-Hydroxyisoleucine as a Natural DPP-4 Inhibitor for Diabetes

Biology, Medicine & Natural Product Chemistry
Research on 4-hydroxyisoleucine, a natural compound found in several plant sources, shows potential as an antidiabetic agent through inhibiting the DPP-4 (dipeptidyl peptidase-4) enzyme.
Amir Thalib, Irma Putri Damayanti
doaj   +1 more source

Evaluation of Transition Metal Complexes of Benzimidazole-Derived Scaffold as Promising Anticancer Chemotherapeutics

Molecules, 2018
Three new transition metal complexes, Cu(II) 1, Co(II) 2, and Zn(II) 3 with ligand “bimnap” derived from 1-methyl-2-aminobenzimidazole and 2-hydroxynapthaldehyde were synthesized and characterized.
Afzal Hussain, Mohamed F. AlAjmi, Md. Tabish Rehman, Azmat Ali Khan, Perwez Alam Shaikh, Rais Ahmad Khan   +5 more
doaj   +1 more source

Assessing patient risk, benefit, and outcomes in drug development: a decade of vemurafenib clinical trials

Melanoma Management
Background Vemurafenib (Zelboraf®, Roche), approved by the FDA in 2011 for unresectable and metastatic melanoma and Erdheim-Chester Disease, has been explored in trials for other BRAF-mutated cancers.
Taylor Gardner, Jacob Duncan, Griffin K. Hughes, Ryan McIntire, Brooke Gardner, Andriana Peña, Chase Ladd, Kelsey Snider, Ryan Ottwell, Jordan Tuia, Alyson Haslam, Vinay Prasad, Matt Vassar   +12 more
doaj   +1 more source