Results 21 to 30 of about 384,674 (248)

Circulating microRNA Profiles in Acetaminophen Toxicity

Journal of Medical Toxicology, 2019
Acetaminophen toxicity has been associated with elevation of microRNAs. The present study was to evaluate overall microRNA profiles and previously identified microRNAs to differentiate acetaminophen (APAP) toxicity from other causes of transaminase elevation.This was an observational study of adults with presumed acetaminophen toxicity at presentation.
Stephanie Carreiro, James Marvel-Coen, Rosalind Lee, Brittany Chapman, Victor Ambros   +4 more
openaire   +4 more sources

In silico Toxicity Prediction of Ethanol Extract of Cola rostrata (K. Schum.) Epicarp

Biology, Medicine & Natural Product Chemistry
. The ethanol extract of the epicarp of Cola rostrata fruit has been reported to possess notable pharmacological properties, including anticancer, anti-inflammatory and antidiabetic effects; however, its toxicological profile remains understudied.
Babatunde Ebenezer Ajayi, Oluwafemi Segun Aina, Albert Kolawole Odunlade, Bamidele Joseph Minari   +3 more
doaj   +1 more source

In Silico Study of Bioactive Compounds Fucoxanthin and Fucoidan from Sargassum echinocarpum as Anti-Cancer Agents Targeting Caspase-3 Protein

Aquatic Life Sciences
Cancer is a complex disease characterized by disruptions in cell regulation mechanisms, leading to abnormal or uncontrolled cell growth and the ability to spread to other parts of the body.
Lulus Mualimin, Mentari Sekar Arum
doaj   +1 more source

Time Toxicity in Wilms Tumor: Quantifying the Burden of Healthcare Interaction in the First Year After Diagnosis

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Wilms tumor (WT) treatment imposes a significant time burden on patients and their families. Time toxicity is a patient‐centered metric that quantifies the burden of healthcare interaction. We sought to define time toxicity in the first year after diagnosis of WT and hypothesized that it would increase as tumor stage and treatment ...
Caleb Q. Ashbrook, Veerain Gupta, Nicholas J. Clark, Vijay Rings, Lauren E. Corona, Douglass B. Clayton, Daniel J. Benedetti   +6 more
wiley   +1 more source

Role of Proton Beam Therapy in Hepatic Oligometastasis: Review of Evidence

Acta Medica Lituanica
Hepatic oligometastasis (hOMC) incidence varies from 10-40% in the literature. While the old standard for local treatment was surgical resection, options like TACE, TARE, SBRT with photons and off late protons have come to the fore.
Satyajeet Rath
doaj   +1 more source

Emapalumab for Immune Effector Cell‐Associated Hemophagocytic Lymphohistiocytosis‐Like Syndrome Following CD19‐Directed CAR‐T in Two Patients With B‐ALL: Clinical and Biomarker Correlates

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Immune effector cell‐associated hemophagocytic lymphohistiocytosis‐like syndrome (IEC‐HS) is a life‐threatening hyperinflammatory toxicity distinct from cytokine release syndrome (CRS) and neurotoxicity following chimeric antigen receptor T‐cell (CAR‐T) therapy. In a single‐institution retrospective cohort of pediatric and young adult patients
Thomas J. Galletta, Jeremy D. Rubinstein, Christopher E. Dandoy, Ruby Khoury, Angela Faulhaber, Christine L. Phillips, Christa Krupski   +6 more
wiley   +1 more source

An epidemiological study of poisoning cases in Babol (northern Iran) from 2015 to 2018

Caspian Journal of Internal Medicine, 2021
Background: Poisoning is a major public health problem that constitutes a significant share of the global burden of disease. Previous studies conducted in this area indicated the importance of such epidemiological studies.
Mohammad Barary, Marzieh Pirzadeh, Nastaran Rezaeian, Mahsa Dadashnia, Sara Mohammadi-Daniali, Fatemeh Pahlavani, Aliasghar Manouchehri, Sohrab Kazemi, Aliakbar Moghadamnia   +8 more
doaj  

Cardiovascular Toxicity Profiles of Vascular-Disrupting Agents [PDF]

The Oncologist, 2011
AbstractBackground.Vascular-disrupting agents (VDAs) represent a new class of chemotherapeutic agent that targets the existing vasculature in solid tumors. Preclinical and early-phase trials have demonstrated the promising therapeutic benefits of VDAs but have also uncovered a distinctive toxicity profile highlighted by cardiovascular events.Methods.We
Ishwaria M, Subbiah, Daniel J, Lenihan, Apostolia M, Tsimberidou   +2 more
openaire   +2 more sources

Fenchone, a monoterpene: Toxicity and diuretic profiling in rats

Frontiers in Pharmacology, 2023
Fenchone is a monoterpene present in the essential oils of various plants, includingFoeniculum vulgareandPeumus boldus. Previous studies confirmed the anti-inflammatory, antioxidant, wound-healing, antidiarrheal, antifungal, antinociceptive, and bronchodilator activities of fenchone.
Asifa Bashir, Muhammad Naveed Mushtaq, Waqas Younis, Irfan Anjum   +3 more
openaire   +3 more sources

The Role of Hematopoietic Cell Transplantation in Ataxia‐Telangiectasia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Ataxia‐telangiectasia (A‐T) is a DNA repair disorder characterized by neurodegeneration, immunodeficiency, and cancer predisposition. Hematopoietic cell transplantation (HCT) is an established therapy in related disorders such as Fanconi anemia (FA) and Nijmegen breakage syndrome (NBS), but its role in A‐T is unclear.
Laila Alkhouli, Seth Rotz, Masatoshi Takagi, Richa Sharma   +3 more
wiley   +1 more source