Results 21 to 30 of about 409,767 (250)

Circulating microRNA Profiles in Acetaminophen Toxicity

Journal of Medical Toxicology, 2019
Acetaminophen toxicity has been associated with elevation of microRNAs. The present study was to evaluate overall microRNA profiles and previously identified microRNAs to differentiate acetaminophen (APAP) toxicity from other causes of transaminase elevation.This was an observational study of adults with presumed acetaminophen toxicity at presentation.
Stephanie Carreiro, James Marvel-Coen, Rosalind Lee, Brittany Chapman, Victor Ambros   +4 more
openaire   +4 more sources

Fenchone, a monoterpene: Toxicity and diuretic profiling in rats

Frontiers in Pharmacology, 2023
Fenchone is a monoterpene present in the essential oils of various plants, includingFoeniculum vulgareandPeumus boldus. Previous studies confirmed the anti-inflammatory, antioxidant, wound-healing, antidiarrheal, antifungal, antinociceptive, and bronchodilator activities of fenchone.
Asifa Bashir, Muhammad Naveed Mushtaq, Waqas Younis, Irfan Anjum   +3 more
openaire   +3 more sources

In Silico Study of Bioactive Compounds Fucoxanthin and Fucoidan from Sargassum echinocarpum as Anti-Cancer Agents Targeting Caspase-3 Protein

Aquatic Life Sciences
Cancer is a complex disease characterized by disruptions in cell regulation mechanisms, leading to abnormal or uncontrolled cell growth and the ability to spread to other parts of the body.
Lulus Mualimin, Mentari Sekar Arum
doaj   +1 more source

Central Nervous System Tumors Among Infants in Canada: A Report From CYP‐C

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) tumors in infants are rare, pose unique clinical challenges, and lack large‐scale evidence‐based data to guide management. This study seeks to describe CNS tumors in Canadian infants and to compare their outcomes with those of older children.
Samuel Sassine, Hallie Coltin, Sylvia Cheng, Lucie Lafay‐Cousin, Vanan Issai Magimairajan, Craig Erker, Stéphanie Vairy, Lynette Bowes, Adam Fleming, Donna Johnston, Sarah McKillop, Roona Sinha, Julie Bennett, Christina Coleman, Laura Wheaton, Shayna Zelcer, Samuele Renzi, Thai Hoa Tran   +17 more
wiley   +1 more source

Role of Proton Beam Therapy in Hepatic Oligometastasis: Review of Evidence

Acta Medica Lituanica
Hepatic oligometastasis (hOMC) incidence varies from 10-40% in the literature. While the old standard for local treatment was surgical resection, options like TACE, TARE, SBRT with photons and off late protons have come to the fore.
Satyajeet Rath
doaj   +1 more source

Toxicity Profile of Silodosin (KMD-3213)

YAKUGAKU ZASSHI, 2006
The toxicity profile of silodosin, a selective alpha(1A)-adrenoceptor antagonist, was evaluated. The lethal doses were 800 mg/kg in rats and 1500 mg/kg in dogs. Repeated-dose studies revealed fatty degeneration of hepatocytes and an induction of drug-metabolizing enzymes at 15 mg/kg/day or more in male rats, mammary gland hyperplasia at 60 mg/kg/day or
Shin-ichi, Muto, Hiroko, Kasahara, Ryohei, Yokoi, Morimichi, Hayashi, Shinji, Souma, Kazuo, Kobayashi, Toru, Tamura, Makoto, Murakami, Junji, Kuroda, Nobuo, Shibata   +9 more
openaire   +4 more sources

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source

Isothiazolinone Biocides: Chemistry, Biological, and Toxicity Profiles [PDF]

Molecules, 2020
The importance of isothiazole and of compounds containing the isothiazole nucleus has been growing over the last few years. Isothiazolinones are used in cosmetic and as chemical additives for occupational and industrial usage due to their bacteriostatic and fungiostatic activity.
Silva, Vânia, Silva, Catia, Soares, Pedro, Garrido, E. Manuela, Borges, Fernanda, Garrido, J.   +5 more
openaire   +4 more sources

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

An epidemiological study of poisoning cases in Babol (northern Iran) from 2015 to 2018

Caspian Journal of Internal Medicine, 2021
Background: Poisoning is a major public health problem that constitutes a significant share of the global burden of disease. Previous studies conducted in this area indicated the importance of such epidemiological studies.
Mohammad Barary, Marzieh Pirzadeh, Nastaran Rezaeian, Mahsa Dadashnia, Sara Mohammadi-Daniali, Fatemeh Pahlavani, Aliasghar Manouchehri, Sohrab Kazemi, Aliakbar Moghadamnia   +8 more
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