Results 21 to 30 of about 385,407 (247)

Assessing patient risk, benefit, and outcomes in drug development: a decade of vemurafenib clinical trials

Melanoma Management
Background Vemurafenib (Zelboraf®, Roche), approved by the FDA in 2011 for unresectable and metastatic melanoma and Erdheim-Chester Disease, has been explored in trials for other BRAF-mutated cancers.
Taylor Gardner, Jacob Duncan, Griffin K. Hughes, Ryan McIntire, Brooke Gardner, Andriana Peña, Chase Ladd, Kelsey Snider, Ryan Ottwell, Jordan Tuia, Alyson Haslam, Vinay Prasad, Matt Vassar   +12 more
doaj   +1 more source

Pesticide Toxicity Profile: Triazine Pesticides

EDIS, 2006
This document provides a general overview of human toxicity, provides a listing of laboratory animal and wildlife toxicities and a cross reference of chemical, common and trade names of triazine pesticides registered for use in Florida.
Frederick M. Fishel
doaj   +5 more sources

In Silico Study of Bioactive Compounds Fucoxanthin and Fucoidan from Sargassum echinocarpum as Anti-Cancer Agents Targeting Caspase-3 Protein

Aquatic Life Sciences
Cancer is a complex disease characterized by disruptions in cell regulation mechanisms, leading to abnormal or uncontrolled cell growth and the ability to spread to other parts of the body.
Lulus Mualimin, Mentari Sekar Arum
doaj   +1 more source

Circulating microRNA Profiles in Acetaminophen Toxicity

Journal of Medical Toxicology, 2019
Acetaminophen toxicity has been associated with elevation of microRNAs. The present study was to evaluate overall microRNA profiles and previously identified microRNAs to differentiate acetaminophen (APAP) toxicity from other causes of transaminase elevation.This was an observational study of adults with presumed acetaminophen toxicity at presentation.
Stephanie Carreiro, James Marvel-Coen, Rosalind Lee, Brittany Chapman, Victor Ambros   +4 more
openaire   +4 more sources

In silico Toxicity Prediction of Ethanol Extract of Cola rostrata (K. Schum.) Epicarp

Biology, Medicine & Natural Product Chemistry
. The ethanol extract of the epicarp of Cola rostrata fruit has been reported to possess notable pharmacological properties, including anticancer, anti-inflammatory and antidiabetic effects; however, its toxicological profile remains understudied.
Babatunde Ebenezer Ajayi, Oluwafemi Segun Aina, Albert Kolawole Odunlade, Bamidele Joseph Minari   +3 more
doaj   +1 more source

Pesticide Toxicity Profile: Strobilurin Pesticides

EDIS, 2005
This document provides a general overview of human toxicity, provides a listing of laboratory animal and wildlife toxicities and a cross reference of chemical, common and trade names of the strobilurin pesticides registered for use in Florida.
Frederick M. Fishel
doaj   +5 more sources

Central Nervous System Neuroblastoma, FOXR2‐Activated: A Pooled Analysis of Published Clinical Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Central nervous system (CNS) neuroblastoma, FOXR2‐activated, is a recently recognized entity in the WHO CNS5 classification, defined by activation of the FOXR2 transcription factor and unique histopathological features. This review synthesizes available literature and pooled clinical data, providing insight into demographics ...
Sudarshawn Damodharan, Mohamed S. Abdelbaki   +1 more
wiley   +1 more source

Role of Proton Beam Therapy in Hepatic Oligometastasis: Review of Evidence

Acta Medica Lituanica
Hepatic oligometastasis (hOMC) incidence varies from 10-40% in the literature. While the old standard for local treatment was surgical resection, options like TACE, TARE, SBRT with photons and off late protons have come to the fore.
Satyajeet Rath
doaj   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

Personalized Zebrafish Models for Fusion‐Positive Pediatric Sarcomas

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Clinical sequencing efforts have revolutionized our approaches to categorizing pediatric cancers in real time. This has dramatically improved our ability to profile pediatric tumors, identify actionable vulnerabilities, and influence clinical care.
Lisa H. Hall, Emma N. Harrison, Genevieve C. Kendall   +2 more
wiley   +1 more source