Results 31 to 40 of about 385,407 (247)

Cardiovascular Toxicity Profiles of Vascular-Disrupting Agents [PDF]

The Oncologist, 2011
AbstractBackground.Vascular-disrupting agents (VDAs) represent a new class of chemotherapeutic agent that targets the existing vasculature in solid tumors. Preclinical and early-phase trials have demonstrated the promising therapeutic benefits of VDAs but have also uncovered a distinctive toxicity profile highlighted by cardiovascular events.Methods.We
Ishwaria M, Subbiah, Daniel J, Lenihan, Apostolia M, Tsimberidou   +2 more
openaire   +2 more sources

Fenchone, a monoterpene: Toxicity and diuretic profiling in rats

Frontiers in Pharmacology, 2023
Fenchone is a monoterpene present in the essential oils of various plants, includingFoeniculum vulgareandPeumus boldus. Previous studies confirmed the anti-inflammatory, antioxidant, wound-healing, antidiarrheal, antifungal, antinociceptive, and bronchodilator activities of fenchone.
Asifa Bashir, Muhammad Naveed Mushtaq, Waqas Younis, Irfan Anjum   +3 more
openaire   +3 more sources

Early Impact of Childhood Opportunity on Neurocognitive Outcomes in Sickle Cell Disease

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Neurocognitive impairment is a well‐recognized complication of sickle cell disease (SCD) that begins early in childhood and persists across development. While cerebrovascular injury contributes substantially to risk, neurocognitive deficits are also observed in children without overt or silent cerebral infarctions, suggesting ...
Julia E. LaMotte, Hannah Koch, Olivia A. Coughlin, Jillian R. Bouck, Allie Carter, Seethal A. Jacob   +5 more
wiley   +1 more source

Pesticide Toxicity Profile: Boric Acid

EDIS, 2005
This document provides a general overview of human toxicity, provides a listing of laboratory animal and wildlife toxicities and a cross reference of chemical, common and trade names of boric acid insecticides registered for use in Florida.
Frederick M. Fishel
doaj   +3 more sources

An epidemiological study of poisoning cases in Babol (northern Iran) from 2015 to 2018

Caspian Journal of Internal Medicine, 2021
Background: Poisoning is a major public health problem that constitutes a significant share of the global burden of disease. Previous studies conducted in this area indicated the importance of such epidemiological studies.
Mohammad Barary, Marzieh Pirzadeh, Nastaran Rezaeian, Mahsa Dadashnia, Sara Mohammadi-Daniali, Fatemeh Pahlavani, Aliasghar Manouchehri, Sohrab Kazemi, Aliakbar Moghadamnia   +8 more
doaj  

Toxicity Profile of Silodosin (KMD-3213)

YAKUGAKU ZASSHI, 2006
The toxicity profile of silodosin, a selective alpha(1A)-adrenoceptor antagonist, was evaluated. The lethal doses were 800 mg/kg in rats and 1500 mg/kg in dogs. Repeated-dose studies revealed fatty degeneration of hepatocytes and an induction of drug-metabolizing enzymes at 15 mg/kg/day or more in male rats, mammary gland hyperplasia at 60 mg/kg/day or
Shin-ichi, Muto, Hiroko, Kasahara, Ryohei, Yokoi, Morimichi, Hayashi, Shinji, Souma, Kazuo, Kobayashi, Toru, Tamura, Makoto, Murakami, Junji, Kuroda, Nobuo, Shibata   +9 more
openaire   +4 more sources

Childhood Acute Lymphoblastic Leukemia Survival in Western Kenya: Reduction in Early Deaths and Treatment Abandonment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An earlier study on children diagnosed with acute lymphoblastic leukemia (ALL) at Moi Teaching and Referral Hospital (MTRH) in Kenya reported a low event‐free survival (EFS), excess treatment abandonment, and high induction mortality.
Gilbert Olbara, George Bogonko, Festus Njuguna, Sandra Langat, Martha Kipngetich, Dennis Njenga, Gertjan Johannes Kaspers, Terry Allen Vik   +7 more
wiley   +1 more source

Pesticide Toxicity Profile: Neonicotinoid Pesticides

EDIS, 2005
This document provides a general overview of human toxicity, provides a listing of laboratory animal and wildlife toxicities and a cross reference of chemical, common and trade names of many neonicotinoid pesticides registered for use in Florida.
Frederick M. Fishel
doaj   +3 more sources

Pharmacological Profile of Cefepime Plus Enmetazobactam in the Treatment of Complicated Urinary Tract Infections Including Catheter-Associated Urinary Tract Infection (CAUTI)

Amrita Journal of Medicine
Cefepime plus enmetazobactam represents a breakthrough novel combination of a β-lactam antibiotic and a β-lactamase inhibitor, which demonstrates extensive antibacterial activity against a wide range of both gram-positive and gram-negative bacteria.
Raja Chakraverty, Tatini Debnath, Samarendra Nath Samui   +2 more
doaj   +1 more source

Phase Angle as an Early Functional Biomarker of Cancer‐Related Fatigue in Pediatric Oncology: A Prospective Longitudinal Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Pediatric cancer remains a leading cause of morbidity and mortality worldwide, particularly in low‐and middle‐income countries. Cancer treatment may impair nutritional status, alter body composition, and exacerbate cancer‐related fatigue (CRF).
Luís Carlos Lopes‐Junior, Luiz Claudio Barreto Silva Neto, Fabiano Kenji Haraguchi, Letícia Batista de Azevedo, Marcelo Brenner Nascimento Carlini, Raphael Manhães Pessanha, Mariana Rabello Laignier, Wesley Rocha Grippa, Tania Mara Lopes Bitti Bortolini, Gláucia Zouain‐Figueiredo, Regina Aparecida Garcia de Lima, Liliana Vasquez   +11 more
wiley   +1 more source