Results 71 to 80 of about 1,840,438 (269)

Development of a Prognostic Model for the Outcome of Viral Lung Disease Using Machine Learning Algorithms

Инновационная медицина Кубани
Background: During periods of increasing respiratory infections, stratifying patient care for virus-associated lung injury is crucial.Objective: To develop a prognostic model for the outcome of viral lung injury using machine learning algorithms ...
E. A. Borodulina, E. S. Vdoushkina, K. I. Shakhgeldyan, E. A. Kurdyukova, B. E. Borodulin, S. Y. Pushkin, K. V. Zhilinskaya   +6 more
doaj   +1 more source

Some Aspects of the Systemic Functional Model in Text Analysis

ELOPE, 2004
The article presents some aspects of text explanation in the systemic functional model of language. In the systemic functional model text is conceived as a semantic unit created in the process of selection and realization of meaningful choices encoded ...
Katja Plemenitaš
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

DOCTOR-PATIENT INTERACTION: A SYSTEMIC FUNCTIONAL ANALYSIS

Language Literacy: Journal of Linguistics, Literature, and Language Teaching, 2018
One of the basic mediums in the interaction between doctor and patient in the treatment room is language. This paper, hence deals with the conversation in doctor-patients interaction in Pirngadi General Hospital in Medan, Indonesia.
Isli Iriani Indiah Pane, Amrin Saragih, Nurlela Nurlela, Masdiana Lubis   +3 more
doaj   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

SYSTEMIC ANALYSIS OF THE CONTROLLING MODEL AT INDUSTRIAL ENTERPRISE

Russian Journal of Economics and Law, 2012
The article proposes the procedure of systemic analysis of controlling model. The process of forming multiple goals and tasks in the controlling system is based on one of the well-known techniques of constructing a tree of goals by Sagatovskiy.
P. V. Laptev, I. I. Potapova
doaj  

A mathematical framework for human neutrophil state transitions inferred from single-cell RNA sequence data

Frontiers in Immunology
Neutrophils, the most abundant immune cells in the human circulation, play a central role in the innate immune system. While neutrophil heterogeneity is a topic of increasing research interest, few efforts have been made to model the dynamics of ...
Gustaf Wigerblad, Jonathan Carruthers, Sumanta Ray, Sumanta Ray, Thomas Finnie, Grant Lythe, Saumyadipta Pyne, Saumyadipta Pyne, Saumyadipta Pyne, Carmen Molina-París, Carmen Molina-París, Mariana J. Kaplan   +11 more
doaj   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source