Results 101 to 110 of about 15,163,780 (323)

Stone Circular Design and Material Regeneration

DIID
This contribution aims to investigate the strategic role of design within the ecological transition and the circular economy, through an in-depth analysis of the STONE project.
Gabriele Pontillo, Silvana Bruno, Alessio Tanzini, Fabio Fatiguso   +3 more
doaj   +1 more source

Redox regulation meets metabolism: targeting PRDX2 to prevent hepatocellular carcinoma

Molecular Oncology, EarlyView.
PRDX2 acts as a central redox hub linking metabolic dysfunction‐associated steatohepatitis (MASH) to hepatocellular carcinoma (HCC). In normal hepatocytes, PRDX2 maintains redox balance and metabolic homeostasis under oxidative stress. In contrast, during malignant transformation, PRDX2 promotes oncogenic signaling, stemness, and tumor initiation ...
Naroa Goikoetxea‐Usandizaga, María Luz Martinez‐Chantar, Carolina Conter   +2 more
wiley   +1 more source

Navigating systemic risks in low-carbon energy transitions in an era of global polycrisis

Global Sustainability
Non-technical summary Accelerating global systemic risks impel as well as threaten low-carbon energy transitions. Polycrises can undermine low-carbon transitions, and the breakdown of low-carbon energy transitions has the potential to intensify ...
Ashwin K. Seshadri, Ajay Gambhir, Ramit Debnath   +2 more
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

System Level Design

, 1993
In this contribution, some aspects of system level design are discussed. After a short characterization of the term system level, most emphasis is laid on modelling aspects. Various modelling techniques are discussed and a specific model, extended Pr/T-Nets are introduced in detail. A short overview of other system level activities concludes this paper.
openaire   +2 more sources

Design research methods in systematic design [PDF]

, 2014
Systemic design is distinguished from user-oriented and service design practices in several key respects: The expansion and negotiation of system boundaries to frame the design situation, the intentional embrace of sociotechnical complexity, and ...
Jones, Peter
core  

The significance of macrophage polarization subtypes for animal models of tissue fibrosis and human fibrotic diseases. [PDF]

, 2015
The systemic and organ-specific human fibrotic disorders collectively represent one of the most serious health problems world-wide causing a large proportion of the total world population mortality.
Ballater R, Beon M, Bryan N, Butterfield TA, Connolly MK, Desmoulière A, Fallowfield JA, Galván‐Peña S, Gordon S, Goumans M, Hu B, Ito T, Jimenez SA, Korns D, Krieg T, Lassen S, Lech M, Leibovich SJ, Lev B, Mantovani A, Mantovani A, Molumdar K, Nestle FO, O’Doherty U, Piera‐Velazquez S, Poland GA, Rafii R, Rigamonte E, Tacke F, Venbervliet B, Wang Y, Wick G, Wijesundera KK   +32 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

A Systemic/Cybernetic Notion of Design [PDF]

Journal of Systemics, Cybernetics and Informatics, 2019
The purpose of writing this article is 1) to describe the notion1 of "design" in order to show that there is almost no thought-based activity that does not, explicitly or implicitly, contains designing activities, including academic and scientific ones ...
Nagib Callaos
doaj  

Relating Systems Thinking and Design III

FORMakademisk, 2017
This special issue of Form Akademisk captures some of the systemic design thinking and research presented at the RSD3 conference, held in Oslo, Norway in 2014, and the RSD4 conference, held in Banff, Canada in 2015.
Jodi Forlizzi, Birger Sevaldson, Alex Ryan   +2 more
doaj   +1 more source