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Systemic Diseases [PDF]

open access: yesClinical Journal of the American Society of Nephrology, 2010
Hereditary fibrinogen A -chain amyloidosis: Phenotypic characterization of a systemic disease and the role of liver transplantation. Blood 115: 2998–3007, 2010 Arie J. Stangou, Nicholas R. Banner, Bruce M. Hendry, Mohamed Rela, Bernard Portmann, Julia Wendon, Mark Monaghan, Philip MacCarthy, Muriel Buxton-Thomas, Christopher J.
Antonio Fernandez-Nebro   +8 more
  +8 more sources

Endothelial Progenitor Cells: Relevant Players in the Vasculopathy and Lung Fibrosis Associated with the Presence of Interstitial Lung Disease in Systemic Sclerosis Patients

open access: yesBiomedicines, 2021
Endothelial progenitor cells (EPC), which are key effectors in the physiologic vascular network, have been described as relevant players in autoimmune diseases.
Verónica Pulito-Cueto   +15 more
doaj   +1 more source

Thrombosis and Hyperinflammation in COVID-19 Acute Phase Are Related to Anti-Phosphatidylserine and Anti-Phosphatidylinositol Antibody Positivity

open access: yesBiomedicines, 2023
Antiphospholipid antibodies (APLA) are strongly associated with thrombosis seen in patients with antiphospholipid syndrome. In COVID-19, thrombosis has been observed as one of the main comorbidities.
Jaume Alijotas-Reig   +5 more
doaj   +1 more source

Angiogenic T Cells: Potential Biomarkers for the Early Diagnosis of Interstitial Lung Disease in Autoimmune Diseases?

open access: yesBiomedicines, 2022
(1) Background: We explored, for the first time, the contribution of angiogenic T cells (TAng) in interstitial lung disease associated to autoimmune disease (AD-ILD+) as potential biomarkers of the disease, evaluating their role in the underlying ...
Verónica Pulito-Cueto   +15 more
doaj   +1 more source

Disease activity influences the reclassification of rheumatoid arthritis into very high cardiovascular risk

open access: yesArthritis Research & Therapy, 2021
Background Previous studies have shown that risk chart algorithms, such as the Systematic Coronary Risk Assessment (SCORE), often underestimate the actual cardiovascular (CV) risk of patients with rheumatoid arthritis (RA).
Iván Ferraz-Amaro   +7 more
doaj   +1 more source

Systemic autoinflammatory diseases

open access: yesJournal of Autoimmunity, 2020
Systemic autoinflammatory diseases (SAIDs) are a growing group of disorders caused by a dysregulation of the innate immune system leading to episodes of systemic inflammation. In 1997, MEFV was the first gene identified as disease causing for Familial Mediterranean Fever, the most common hereditary SAID.
Krainer, Julie   +2 more
openaire   +2 more sources

Neutrophil-Derived IL-6 Potentially Drives Ferroptosis Resistance in B Cells in Lupus Kidney

open access: yesMediators of Inflammation, 2023
Ferroptosis resistance is vital for B cell development, especially in inflammatory diseases, yet the underlying mechanism is still unclear. In this study, based on the scRNA-seq technique and flow cytometry, we discovered a proportion of neutrophils ...
Zechen Wang   +9 more
doaj   +1 more source

Role of VEGF Polymorphisms in the Susceptibility and Severity of Interstitial Lung Disease

open access: yesBiomedicines, 2021
The search for biomarkers that can help to establish an early diagnosis and prognosis of interstitial lung disease (ILD) is of potential interest. VEGF polymorphisms have been implicated in the development of several lung disorders.
Sara Remuzgo-Martínez   +18 more
doaj   +1 more source

Impact of severe infections in SLE: an observational study from the Spanish national registry

open access: yesLupus Science and Medicine, 2022
Objective Infections are a common complication of SLE. Our objective was to evaluate their causes and impact on the survival of patients with SLE.Methods Analysis of the admissions and death causes in patients diagnosed with SLE from the Spanish Hospital
Guillermo Ruiz-Irastorza   +11 more
doaj   +1 more source

Can a decision support system accelerate rare disease diagnosis? Evaluating the potential impact of Ada DX in a retrospective study

open access: yesOrphanet Journal of Rare Diseases, 2019
Background Rare disease diagnosis is often delayed by years. A primary factor for this delay is a lack of knowledge and awareness regarding rare diseases.
Simon Ronicke   +5 more
doaj   +1 more source

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