Results 111 to 120 of about 1,311,352 (316)

Nuclear receptor corepressor 1 represses cardiac hypertrophy

EMBO Molecular Medicine, 2019
The function of nuclear receptor corepressor 1 (NCoR1) in cardiomyocytes is unclear, and its physiological and pathological implications are unknown. Here, we found that cardiomyocyte‐specific NCoR1 knockout (CMNKO) mice manifested cardiac hypertrophy at
Chao Li, Xue‐Nan Sun, Bo‐Yan Chen, Meng‐Ru Zeng, Lin‐Juan Du, Ting Liu, Hui‐Hui Gu, Yuan Liu, Yu‐Lin Li, Lu‐Jun Zhou, Xiao‐Jun Zheng, Yu‐Yao Zhang, Wu‐Chang Zhang, Yan Liu, Chaoji Shi, Shuai Shao, Xue‐Rui Shi, Yi Yi, Xu Liu, Jun Wang, Johan Auwerx, Zhao V Wang, Feng Jia, Ruo‐Gu Li, Sheng‐Zhong Duan   +24 more
doaj   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

FEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani, Eiman Y. Ibrahim, Rozalyn L. Rodwin, Leah M. Ferrucci, Kim Blenman, Maryam Lustberg, Barbara E. Ehrlich   +6 more
wiley   +1 more source

Unveiling biomarkers of telitacicept’s efficacy in SLE treatment through proteomics and metabolomics

Frontiers in Immunology
BackgroundThe pathogenesis of systemic lupus erythematosus (SLE) is closely associated with abnormal activation of B lymphocytes. Telitacicept simultaneously blocks B-cell stimulating factors and proliferation-inducing ligands, thereby inhibiting B-cell ...
Huiyu Nie, Huiyu Nie, Siyuan Chang, Siyuan Chang, Hanhan Chen, Hanhan Chen, Jiahui Shi, Jiahui Shi, Shu Li, Shu Li, Xiaofei Peng, Xiaofei Peng, Wei Cheng, Wei Cheng, Jia Wang, Jia Wang, Qi Tang, Qi Tang, Yan Ge, Yan Ge, Xi Xie, Xi Xie, Fen Li, Fen Li   +23 more
doaj   +1 more source

Oral manifestations in systemic diseases

, 2010
Systemic diseases may affect the oral tissues, i.e. oral mucosa, salivary glands, teeth or bone, and oral manifestations will frequently present early, i.e. in association with (non-fulminant) systemic disease.
Jensen, Siri Beier, Pedersen, Anne Marie Lynge   +1 more
core  

Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis

FEBS Open Bio, EarlyView.
Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho, Rebecca Schmitt, Aneesha Dasgupta, Alexandra Ducharme, Jason Doles   +4 more
wiley   +1 more source

Gastrointestinal Involvement in Systemic Vasculitis

, 2017
Gastrointestinal (GI) manifestations of systemic vasculitides (SVs) are a challenge for the clinician because of the variety and severity, since acute or chronic course can be observed.
QUARTUCCIO, Luca, S. De Vita, DE VITA, Salvatore, L. Quartuccio   +3 more
core   +1 more source

Identifying transcription factors controlling the basal expression of human MRP4 highlights a substantial role for Sp1

FEBS Open Bio, EarlyView.
The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer, Angelique Kragl, Katrin Ziems, Juliane Glaubitz, Sophie Grammbauer, Susanne Hildebrandt, Mladen V. Tzvetkov, Gabriele Jedlitschky   +7 more
wiley   +1 more source

Cancer complicating systemic lupus erythematosus--a dichotomy emerging from a nested case-control study

, 2013
We determined whether any individual cancers are increased or decreased in a cohort of 595 patients with systemic lupus erythematosus (SLE) followed for up to 32 years at the University College London Hospitals Lupus Clinic, looking for any associated ...
Kenu, E, Dey, D, Isenberg, DA
core  

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source