Results 61 to 70 of about 1,195,397 (240)

Epidemiology of Kawasaki disease in the population of the Caribbean Island of Martinique, 2013–2019

BMC Pediatrics
Purpose Kawasaki disease (KD) is a vasculitis of the large and medium vessels. Its description and epidemiology in the Afro-descendant (AD) population and in Latin America and the Caribbean (LAC) are limited.
Doline Monges, Melanie Brard, Hugues Lucron, Sarah Pallara-Sirven, Aurélie Armougon, Hanine Mansour, Claudia Hospice, Christophe Deligny, Yves Hatchuel, Lindsay Osei, Moustapha Dramé, Arthur Felix   +11 more
doaj   +1 more source

Diagnostic value of neutrophil-to-lymphocyte, platelet-to-lymphocyte, and lymphocyte-to-monocyte ratios for assessing organ and multiorgan involvement in sarcoidosis: a retrospective single-center study

Frontiers in Medicine
BackgroundSarcoidosis is a heterogeneous disease lacking reliable biomarkers for organ involvement. Indices derived from the complete blood count (CBC), including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and ...
Estefanía Díaz-Martín, Andrea Fernández-Valmaña, Jesús López-Martínez, Alex Mayer-Fuentes, Joan María Mercadé-Torras, María García-González, Laia Mas-Maresma, Blanca Carrillo-Lampe, Joel Font-Majo, Begoña Marí-Alfonso, Carlos Feijoo-Massó   +10 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Pituitary–Adrenal Axis and Peripheral Immune Cell Profile in Long COVID

Biomedicines
In Long COVID, dysfunction in the pituitary–adrenal axis and alterations in immune cells and inflammatory status are warned against. We performed a prospective study in a cohort of 42 patients who suffered COVID-19 at least 6 months before attending the ...
Jaume Alijotas-Reig, Ariadna Anunciacion-Llunell, Enrique Esteve-Valverde, Stephanie Morales-Pérez, Sergio Rivero-Santana, Jaume Trapé, Laura González-García, Domingo Ruiz, Joana Marques-Soares, Francesc Miro-Mur   +9 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Markers Of Insulin Resistance and Their Clinical Implications In Patients with Type 2 Diabetes and Metabolic Dysfunction-Associated Steatotic Liver Disease

Diabetes, Metabolic Syndrome and Obesity
Oana Albai,1– 3 Adina Braha,1– 3 Romulus Timar,1– 3 Sandra Lazar,3– 6 Simona Popescu,1– 3 Bogdan Timar1– 3 1Department of Second Internal Medicine—Diabetes, Nutrition, Metabolic Diseases, and Systemic Rheumatology, “Victor Babes” University of Medicine ...
Albai O, Braha A, Timar R, Lazar S, Popescu S, Timar B   +5 more
doaj  

Drug Retention Rates and Treatment Discontinuation among Anti-TNF-α Agents in Psoriatic Arthritis and Ankylosing Spondylitis in Clinical Practice

Mediators of Inflammation, 2014
Objective. The study aim was to determine treatment persistence rates and to identify causes of discontinuation in psoriatic arthritis (PsA) and ankylosing spondylitis (AS) patients in clinical practice. Methods.
Marta Fabbroni, Luca Cantarini, Francesco Caso, Luisa Costa, Veronica Anna Pagano, Bruno Frediani, Stefania Manganelli, Mauro Galeazzi   +7 more
doaj   +1 more source

Periodontal disease and systemic disease [PDF]

Journal of the Royal Society of Medicine, 2014
Iain L C, Chapple, Michael, Busby, Henry, Clover, Roger, Matthews   +3 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source