Results 51 to 60 of about 316,936 (347)

Systemic Immune-inflammation Index Is Associated with Symptomatic Cerebral Hyperperfusion after Revascularization Surgery in Moyamoya Disease

Neurologia Medico-Chirurgica
Revascularization surgery for moyamoya disease poses risks of complications, requiring appropriate management. Although precise prediction is difficult, the systemic immune-inflammation index is a calculable marker that reflects systemic inflammatory ...
Taiji YAMAMOTO, Haruto UCHINO, Masaki ITO, Taku SUGIYAMA, Miki FUJIMURA   +4 more
doaj   +1 more source

Systemic Inflammation Response Index and Systemic Immune Inflammation Index Are Associated with Clinical Outcomes in Patients with Acute Pancreatitis?

Journal of Investigative Surgery, 2022
Objectives: The inflammatory response is critically important in acute pancreatitis (AP). Systemic immune-inflammation (SII) index and systemic inflammation response index (SIRI), which are novel inflammatory markers, have been linked to determining ...
Murat Biyik, Zeynep Biyik, Mehmet Asil, Muharrem Keskin   +3 more
doaj   +1 more source

Systemic immune-inflammation index is associated with white matter hyperintensity volume

Scientific Reports, 2022
AbstractSystemic immune-inflammation index (SII) is a novel inflammatory marker based on the composition ratio of blood cell counts. In this study, we evaluated the association between the SII and cerebral small vessel disease (cSVD) in health check-up participants. We evaluated participants from our health check-up registry between 2006 and 2013.
Ki-Woong Nam, Hyung-Min Kwon, Han-Yeong Jeong, Jin-Ho Park, Hyuktae Kwon   +4 more
openaire   +3 more sources

Clinical value of the systemic immune-inflammation index in moyamoya disease

Frontiers in Neurology, 2023
BackgroundMoyamoya disease (MMD) is a rare cerebrovascular disorder with unknown etiology. The underlying pathophysiological mechanism of moyamoya disease remains to be elucidated, but recent studies have increasingly highlighted that abnormal immune response may be a potential trigger for MMD.
Erheng Liu, Erheng Liu, Chengyuan Liu, Chengyuan Liu, Lide Jin, Hu Zhou, Xueyi Tan, Xueyi Tan, Guibo Zhang, Guibo Zhang, Weihua Tao, Xiang Gao, Heng Zhao, Chao Luo, Xuehua Li, Shuaifeng Yang   +15 more
openaire   +3 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

The association between systemic inflammation markers and the prevalence of hypertension

BMC Cardiovascular Disorders, 2023
Background We conducted a large-scale epidemiological analysis to investigate the associations between systemic inflammation markers and hypertension prevalence. Our aim is to identify potential biomarkers for early detection of hypertension.
Nake Jin, Lei Huang, Jun Hong, Xuechen Zhao, Jianan Hu, Shanshan Wang, Xudong Chen, Jiacheng Rong, Yingjie Lu   +8 more
doaj   +1 more source

Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function [PDF]

, 2010
Acute-phase proteins (APPs) are an evolutionarily conserved family of proteins produced mainly in the liver in response to infection and inflammation.
Angus, Badolato, Bernard, Betz, Bozic, Buras, Byl, Cheng, Cheng, Christenson, Christian Trautwein, Delano, Ernst, Fisher, Foreman, Frank Tacke, Gabay, Gabrilovich, Haile, Hoechst, Hotchkiss, Hotchkiss, J. Magarian Blander, Kim, Klein, Kopf, Leif E. Sander, Luchtefeld, Matuschak, Medzhitov, Michael Müller, Movahedi, Murakami, Nagaraj, Naiara Beraza, Nefedova, Parrish, Rebouissou, Reinhold P. Linke, Riedemann, Ritchie, Rittirsch, Rittirsch, Sara Dutton Sackett, Shah, Sinha, Streetz, Tebbutt, Uta Dierssen, Wuestefeld, Yang, Young, Zhu, Zouki   +53 more
core   +4 more sources

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Relationship between tumour PTEN/Akt/COX-2 expression, inflammatory response and survival in patients with colorectal cancer [PDF]

, 2016
In patients with colorectal cancer (CRC), local and systemic inflammatory responses have been extensively reported to associate with cancer survival. However, the specific signalling pathways responsible for inflammatory responses are not clear. The PTEN/
Bennett, Lindsay, Edwards, Joanne, Horgan, Paul G., McMillan, Donald C., Park, James, Powell, Arfon G.M.T., Roseweir, Antonia K., Van Wyk, Hester C.   +7 more
core   +3 more sources