Results 61 to 70 of about 314,857 (293)

Inhibition of neutrophil activity improves cardiac function after cardiopulmonary bypass [PDF]

, 2007
Background The arterial in line application of the leukocyte inhibition module (LIM) in the cardiopulmonary bypass (CPB) limits overshooting leukocyte activity during cardiac surgery.
Abdel-Rahman, Ulf, Margraf, Stefan, Aybek, Tayfun, Lögters, Tim Tobias, Bitu-Moreno, José, Francischetti, Ieda, Kranert, Tilmann, Grünwald, Frank (Prof. Dr.), Windolf, Joachim, Moritz, Anton, Scholz, Martin   +10 more
core   +2 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Association of systemic inflammatory biomarkers with depression risk: Results from National Health and Nutrition Examination Survey 2005–2018 analyses

Frontiers in Psychiatry, 2023
Background/AimDepression has become a multiple disease worldwide, and is closely related to the systemic inflammatory response.MethodsBased on the data of the National Health and Nutrition Examination Survey (NHANES), this study included 2,514 depressive
Xintong Li, Jiaming Huan, Lin Lin, Yuanlong Hu   +3 more
doaj   +1 more source

Pattern recognition receptors as key players in adrenal gland dysfunction during sepsis [PDF]

, 2012
Background: Undergoing systemic inflammation, the innate immune system releases excessive proinflammatory mediators, which finally can lead to organ failure. Pattern recognition receptors (PRRs), such as Toll-like receptors (TLRs) and NOD-like receptors (
Bornstein, Stefan R., Hoesker, Vanessa, Kanczkowski, Waldemar, Tran, Thi Hoai Nguyen, Zacharowski, Kai   +4 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Relationship between emergency presentation, systemic inflammatory response, and cancer-specific survival in patients undergoing potentially curative surgery for colon cancer [PDF]

, 2009
Background Emergency presentation is recognized to be associated with poorer cancer-specific survival following curative resection for colorectal cancer.
Canna, Carstairs, Crumley, Donald C. McMillan, Du Clos, E. Fiona Leitch, Forrest, Franch-Arcas, Gibbs, Glen, Heys, Heys, Hole, John H. Anderson, Joseph E.M. Crozier, Leitch, Longo, Longo, McArdle, McArdle, McMillan, McMillan, McMillan, McMillan, McMillan, Nielsen, Nozoe, Paul G. Horgan, Phillips, Preston, Ruth F. McKee, Scott, Vermeire, Ytting   +33 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Correlation analysis of systemic immune-inflammation index values and arthritis risk in adults

Journal of International Medical Research
Objective To investigate the correlation between systemic immune-inflammation index (SII) values and the risk of arthritis among adult participants.
Xuefei Xia, Yongyong Lou, Yu Zhou, Haoming Ling, Tingting Ge   +4 more
doaj   +1 more source

Modified Mediterranean Diet for Enrichment of Short Chain Fatty Acids: Potential Adjunctive Therapeutic to Target Immune and Metabolic Dysfunction in Schizophrenia? [PDF]

, 2017
Growing interest in gut and digestive processes and their potential link to brain and peripheral based inflammation or biobehavioral phenotypes has led to an increasing number of basic and translational scientific reports focused on the role of gut ...
Cadenhead, Kristen S, Depp, Colin, Joseph, Jamie, Schmid-Schönbein, Geert, Shih, Pei-An B   +4 more
core   +1 more source

LINC01116, a hypoxia‐lncRNA marker of pathological lymphangiogenesis and poor prognosis in lung adenocarcinoma

Molecular Oncology, EarlyView.
The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola, Rafael Lopes Goncalves, Marin Truchi, Caroline Lacoux, Célia Scribe, Hugo Cadis, Laetitia Guardini, Sophie Bekisz, Marius Ilié, Paul Hofman, Georges Vassaux, Bernard Mari, Roger Rezzonico   +12 more
wiley   +1 more source