Results 51 to 60 of about 661,063 (353)

Ferroptosis in periodontitis: mechanisms, impacts, and systemic connections

Cell Death Discovery
Periodontitis is a chronic inflammatory disease initiated by plaque microorganisms, with the regulatory mechanisms of its progression being a primary research focus.
Peng Guan, Qijun Ruan, Jiatong Li, Mengying Xi, Weijuan Qi, Kang I. Ko, Jia Ni   +6 more
doaj   +1 more source

Socio-economic Impacts—Agricultural Systems [PDF]

, 2016
Europe is one of the world’s largest and most productive suppliers of food and fibre. In the North Sea region, agroecosystems vary from highly productive farming systems such as the arable cropping systems of western Europe to low-input and low-output farming systems with or without livestock. Climate change impacts on agricultural production will vary
openaire   +2 more sources

Earth-like Habitats in Planetary Systems

, 2014
Understanding the concept of habitability is related to an evolutionary knowledge of the particular planet-in-question. Additional indications so-called "systemic aspects" of the planetary system as a whole governs a particular planet's claim on ...
Bitsch, Bertram, Fernandes, Vera A., Fritz, Jörg, Grenfell, Lee J., Kührt, Ekkehard, Morbidelli, Alessandro, Rauer, Heike, Tornow, Carmen, Wagner, Roland, Werner, Stephanie C., Wünnemann, Kai   +10 more
core   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Corrigendum to: “Trustworthiness, Not Trust: How Systemic Racism Impacts COVID-19 Vaccine Receipt” [PDF]

Health Equity
doaj   +2 more sources

Alcohol’s Impact on the Cardiovascular System [PDF]

Nutrients, 2021
Alcohol consumption has been shown to have complex, and sometimes paradoxical, associations with cardiovascular diseases (CVDs). Several hundred epidemiological studies on this topic have been published in recent decades. In this narrative review, the epidemiological evidence will be examined for the associations between alcohol consumption, including ...
openaire   +2 more sources

Assessing impacts of agricultural research for development in countries of the South [PDF]

, 2019
Source Agritrop Cirad (https://agritrop.cirad.fr/594337/)International ...
Barret, Danielle, Dabat, Marie-Hélène, Devaux-Spatarakis, Agathe, Faure, Guy, Hainzelin, Etienne, Mathe, Syndhia, Temple, Ludovic, Toillier, Aurélie, Triomphe, Bernard   +8 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Hypoxia inducible factor 1α-driven steroidogenesis impacts systemic hematopoiesis

Cellular & Molecular Biology Letters
Background Glucocorticoids (GCs) are key regulators of hematopoiesis, but the effects of chronically elevated endogenous GC levels on hematopoietic stem cell (HSC) function and immune cell development remain poorly understood.
Deepika Watts, Nicolas Eberz, Mangesh T. Jaykar, Anupam Sinha, Cagdas Ermis, Johanna Tiebel, Ulrike Baschant, Martina Rauner, Tatyana Grinenko, Triantafyllos Chavakis, Peter Mirtschink, Ali El-Armouche, Ben Wielockx   +12 more
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source