Results 51 to 60 of about 936,764 (268)

Exploring the Boundaries of Systemic Inflammation* [PDF]

Critical Care Medicine, 2014
Understanding the mechanisms that limit or propagate tissue injury during systemic inflammation may provide the basis for preventing secondary organ dysfunction during serious infections. Endotoxin, an outer membrane component of gram-negative bacteria, is the archetypical microbial factor that mediates inflammation associated with these infections ...
Jason M, Elinoff, Anthony F, Suffredini
openaire   +2 more sources

Comparative Evaluation of Hemodiafiltration, Hemoperfusion, and Standard Hemodialysis on Efficacy, Inflammatory Control, Dialysis Adequacy, and Safety in End‐Stage Renal Disease: A Prospective Observational Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Chronic micro‐inflammation in patients with end‐stage renal disease (ESRD) is a significant driver of cardiovascular complications and diminished quality of life. While standard hemodialysis (SHD) effectively manages small‐molecule clearance, its ability to remove medium‐to‐large uremic toxins—the primary catalysts of systemic ...
Hongwei Zuo, Weisi Dai, Jie Mao, Mei Ye, Xingshan Lu, Xiaocui Zhang   +5 more
wiley   +1 more source

House Dust Mite Nebulization Drives Alarmin and Complement Activation in a Murine Tracheal Air–Liquid Interface Culture System

Cells
Air–liquid interface (ALI) cultures offer a physiologically relevant in vitro model of the airway epithelium (AE), capable of recapitulating key structural and functional features observed in vivo. In this study, we established and validated a murine ALI
Janti Haj Ahmad, Philip Einwohlt, Mareike Ohms, Doris Wilflingseder, Jörg Köhl   +4 more
doaj   +1 more source

Anti-rhesus D prophylaxis in pregnant women is based on sialylated IgG antibodies [v1; ref status: indexed, http://f1000r.es/1fg]

F1000Research, 2013
Red blood cells (RBCs) from a rhesus D (RhD)-positive fetus that reach the bloodstream of an RhD-negative pregnant woman during birth can induce a pathogenic antibody (Ab) response against the RhD-positive RBCs, leading to fetal hemolytic disease in ...
André Winkler, Markus Berger, Marc Ehlers   +2 more
doaj   +1 more source

Systemic Inflammation Response Index and Systemic Immune Inflammation Index for Predicting Acute Cholecystitis

Indian Journal of Medical Specialities, 2023
Objective: Acute cholecystitis (AC) is a condition caused by acute inflammation of gallbladder. Many inflammatory markers are frequently used in the diagnostic process. In this study, we wanted to show the diagnostic efficacy of the systemic inflammatory
Günay Yildiz, Fatih Selvi, Cihan Bedel, Ökkes Zortuk, Mustafa Korkut, Umut Ogün Mutlucan   +5 more
doaj   +1 more source

The heterogeneity of systemic inflammation in bronchiectasis [PDF]

Respiratory Medicine, 2017
Systemic inflammation in bronchiectasis is poorly studied in relation to aetiology and severity. We hypothesized that molecular patterns of inflammation may define particular aetiology and severity groups in bronchiectasis.We assayed blood concentrations of 31 proteins from 90 bronchiectasis patients (derivation cohort) and conducted PCA to examine ...
Saleh, Aarash D., Chalmers, James D., De Soyza, Anthony, Fardon, Thomas C., Koustas, Spiro O., Scott, Jonathan, Simpson, A. John, Brown, Jeremy S., Hurst, John R.   +8 more
openaire   +4 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Therapeutic targeting of alternative pathway and C5 but not C5a protects from disease development in a preclinical model of autoimmune blistering dermatosis

Frontiers in Immunology
IntroductionEpidermolysis Bullosa Acquisita (EBA) is an autoimmune blistering dermatosis characterized by autoantibodies (AAbs) against type VII collagen (COL7) located at the dermal epidermal junction (DEJ).
Björn Laffer, Mareike Ohms, Samyr Kenno, Ping Tsui, Elvira Ehlers-Jeske, Wenru Song, Wen-Chao Song, Jörg Köhl   +7 more
doaj   +1 more source

Obesity, inflammation and the immune system [PDF]

Proceedings of the Nutrition Society, 2012
Obesity shares with most chronic diseases the presence of an inflammatory component, which accounts for the development of metabolic disease and other associated health alterations. This inflammatory state is reflected in increased circulating levels of pro-inflammatory proteins, and it occurs not only in adults but also in adolescents and children ...
Pérez de Heredia, F., Gómez-Martínez, Sonia, Marcos, Ascensión   +2 more
openaire   +3 more sources

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source