Results 21 to 30 of about 2,399,468 (309)

C5aR1 Activation Drives Early IFN-γ Production to Control Experimental Toxoplasma gondii Infection

Frontiers in Immunology, 2020
Toxoplasma gondii (T. gondii) is a parasite infecting animals and humans. In intermediate hosts, such as humans or rodents, rapidly replicating tachyzoites drive vigorous innate and adaptive immune responses resulting in bradyzoites that survive within ...
Daria Briukhovetska, Birte Ohm, Fabian T. Mey, Julio Aliberti, Marie Kleingarn, Markus Huber-Lang, Christian M. Karsten, Jörg Köhl, Jörg Köhl   +8 more
doaj   +1 more source

IL-10 revisited in systemic lupus erythematosus

Frontiers in Immunology, 2022
IL-10 is a cytokine with pleiotropic functions, particularly known for its suppressive effects on various immune cells. Consequently, it can limit the pathogenesis of inflammatory diseases, such as multiple sclerosis (MS), inflammatory bowel disease ...
Swayanka Biswas, Katja Bieber, Rudolf Armin Manz   +2 more
doaj   +1 more source

Alterations of the Gut Microbiome in Chinese Zhuang Ethnic Patients with Sepsis

Mediators of Inflammation, 2022
Objectives. Sepsis is characterized as a dysregulated host immune response to infection and has been known to be closely associated with the gut microbiome.
Jieyang Yu, Hongping Li, Jingjie Zhao, Yanhua Huang, Chunlei Liu, Pengfei Yang, Dinggui Lu, Jian Song, Lingzhang Meng   +8 more
doaj   +1 more source

The Melanocortin System in Control of Inflammation [PDF]

The Scientific World JOURNAL, 2010
Melanocortin peptides, the collective term for α-, β-, and γ-melanocyte-stimulating hormone (α-, β-, γ-MSH) and adrenocorticotropic hormone (ACTH), are elements of an ancient modulatory system. Natural melanocortins derive from the common precursor pro-opiomelanocortin (POMC). Five receptor subtypes for melanocortins (MC1-MC5) are widely distributed in
A. Catania, C. Lonati, A. Sordi, A. Carlin, P. Leonardi, S. Gatti   +5 more
openaire   +4 more sources

Transcriptomic Signatures of Airway Epithelium Infected With SARS-CoV-2: A Balance Between Anti-infection and Virus Load

Frontiers in Cell and Developmental Biology, 2021
COVID-19 pneumonia requires effective medical therapies. However, it is a challenge to find therapeutic drugs that not only inhibit viral replication, but also inhibit the accompanying cytokine storm and maintain an appropriate immune response.
Lingzhang Meng, Houji Qin, Jingjie Zhao, Siyuan He, Qiuju Wei, Qiuju Wei, Zechen Wang, Jiajia Shen, Suren Sooranna, Jian Song, Jian Song   +10 more
doaj   +1 more source

The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita

Frontiers in Immunology, 2023
IntroductionThe function of the second receptor for the complement cleavage product C5a, C5aR2, is poorly understood and often neglected in the immunological context.
Daniel L. Seiler, Katja H. Kähler, Marie Kleingarn, Christian D. Sadik, Christian D. Sadik, Katja Bieber, Katja Bieber, Katja Bieber, Jörg Köhl, Jörg Köhl, Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Christian M. Karsten   +13 more
doaj   +1 more source

The B Cell Response and Formation of Allergenic and Anti-Allergenic Antibodies in Food Allergy

Biology, 2023
Food allergies are a growing public health concern worldwide, especially in children and young adults. Allergen-specific IgE plays a central role in the pathogenesis of food allergies, but their titers poorly correlate with allergy development.
Christopher C. Udoye, Marc Ehlers, Rudolf A. Manz   +2 more
doaj   +1 more source

Use of Single Cell Transcriptomic Techniques to Study the Role of High-Risk Human Papillomavirus Infection in Cervical Cancer

Frontiers in Immunology, 2022
High-risk human papillomavirus (hrHPV) infection has been associated with a higher probability of progression to cervical cancer. However, several extensive studies have reported that the presence of hrHPV can lead to a better prognosis, but the ...
Lingzhang Meng, Lingzhang Meng, Shengcai Chen, Guiling Shi, Siyuan He, Zechen Wang, Jiajia Shen, Jiajia Wang, Suren Rao Sooranna, Jingjie Zhao, Jian Song, Jian Song, Jian Song   +12 more
doaj   +1 more source

Preoperative systemic inflammation predicts postoperative infectious complications in patients undergoing curative resection for colorectal cancer [PDF]

, 2009
The presence of systemic inflammation before surgery, as evidenced by the glasgow prognostic score (mGPS), predicts poor long-term survival in colorectal cancer. The aim was to examine the relationship between the preoperative mGPS and the development of
Leitch, E.F., Anderson, J.H., J H Anderson, R F McKee, McMillan, D.C., D C McMillan, Moyes, L.H., P G Horgan, McKee, R.F., L H Moyes, E F Leitch, Horgan, P.G.   +11 more
core   +1 more source

Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b⁺ cDCs Promotes Pulmonary Tolerance through Downregulation of CD40

Cells, 2020
Activation of the C5/C5a/C5a receptor 1 (C5aR1) axis during allergen sensitization protects from maladaptive T cell activation. To explore the underlying regulatory mechanisms, we analyzed the impact of C5aR1 activation on pulmonary CD11b+ conventional ...
Konstantina Antoniou, Fanny Ender, Tillman Vollbrandt, Yves Laumonnier, Franziska Rathmann, Chandrashekhar Pasare, Harinder Singh, Jörg Köhl   +7 more
doaj   +1 more source