Results 21 to 30 of about 927,776 (268)

The Melanocortin System in Control of Inflammation [PDF]

The Scientific World JOURNAL, 2010
Melanocortin peptides, the collective term for α-, β-, and γ-melanocyte-stimulating hormone (α-, β-, γ-MSH) and adrenocorticotropic hormone (ACTH), are elements of an ancient modulatory system. Natural melanocortins derive from the common precursor pro-opiomelanocortin (POMC). Five receptor subtypes for melanocortins (MC1-MC5) are widely distributed in
A. Catania, C. Lonati, A. Sordi, A. Carlin, P. Leonardi, S. Gatti   +5 more
openaire   +4 more sources

Transcriptomic Signatures of Airway Epithelium Infected With SARS-CoV-2: A Balance Between Anti-infection and Virus Load

Frontiers in Cell and Developmental Biology, 2021
COVID-19 pneumonia requires effective medical therapies. However, it is a challenge to find therapeutic drugs that not only inhibit viral replication, but also inhibit the accompanying cytokine storm and maintain an appropriate immune response.
Lingzhang Meng, Houji Qin, Jingjie Zhao, Siyuan He, Qiuju Wei, Qiuju Wei, Zechen Wang, Jiajia Shen, Suren Sooranna, Jian Song, Jian Song   +10 more
doaj   +1 more source

The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita

Frontiers in Immunology, 2023
IntroductionThe function of the second receptor for the complement cleavage product C5a, C5aR2, is poorly understood and often neglected in the immunological context.
Daniel L. Seiler, Katja H. Kähler, Marie Kleingarn, Christian D. Sadik, Christian D. Sadik, Katja Bieber, Katja Bieber, Katja Bieber, Jörg Köhl, Jörg Köhl, Ralf J. Ludwig, Ralf J. Ludwig, Ralf J. Ludwig, Christian M. Karsten   +13 more
doaj   +1 more source

The B Cell Response and Formation of Allergenic and Anti-Allergenic Antibodies in Food Allergy

Biology, 2023
Food allergies are a growing public health concern worldwide, especially in children and young adults. Allergen-specific IgE plays a central role in the pathogenesis of food allergies, but their titers poorly correlate with allergy development.
Christopher C. Udoye, Marc Ehlers, Rudolf A. Manz   +2 more
doaj   +1 more source

Use of Single Cell Transcriptomic Techniques to Study the Role of High-Risk Human Papillomavirus Infection in Cervical Cancer

Frontiers in Immunology, 2022
High-risk human papillomavirus (hrHPV) infection has been associated with a higher probability of progression to cervical cancer. However, several extensive studies have reported that the presence of hrHPV can lead to a better prognosis, but the ...
Lingzhang Meng, Lingzhang Meng, Shengcai Chen, Guiling Shi, Siyuan He, Zechen Wang, Jiajia Shen, Jiajia Wang, Suren Rao Sooranna, Jingjie Zhao, Jian Song, Jian Song, Jian Song   +12 more
doaj   +1 more source

Systemic inflammation response index and systemic immune-inflammation index are associated with severity of acute pancreatitis [PDF]

Ķazaķstannyṇ Klinikalyķ Medicinasy, 2023
Aim: Acute pancreatitis (AP) is a disease with inflammation, and patients present with severe acute upper abdominal pain in emergency departments. AP can result in higher mortality as its clinical severity increases.
Gunay Yildiz, Fatih Selvi, Cihan Bedel, Okkes Zortuk, Umut Ogün Mutlucan   +4 more
doaj   +1 more source

Allergen-Induced C5a/C5aR1 Axis Activation in Pulmonary CD11b⁺ cDCs Promotes Pulmonary Tolerance through Downregulation of CD40

Cells, 2020
Activation of the C5/C5a/C5a receptor 1 (C5aR1) axis during allergen sensitization protects from maladaptive T cell activation. To explore the underlying regulatory mechanisms, we analyzed the impact of C5aR1 activation on pulmonary CD11b+ conventional ...
Konstantina Antoniou, Fanny Ender, Tillman Vollbrandt, Yves Laumonnier, Franziska Rathmann, Chandrashekhar Pasare, Harinder Singh, Jörg Köhl   +7 more
doaj   +1 more source

A Tumor-Infiltration CD8+ T Cell-Based Gene Signature for Facilitating the Prognosis and Estimation of Immunization Responses in HPV+ Head and Neck Squamous Cell Cancer

Frontiers in Oncology, 2021
BackgroundCD8+ T cells, which play a vital role in response to adaptive immunity, are closely related to the immunization responses to kill tumor cells.
Yingning Wu, Yingning Wu, Yingning Wu, Lingzhang Meng, Kai Cai, Jingjie Zhao, Siyuan He, Jiajia Shen, Qiuju Wei, Qiuju Wei, Zechen Wang, Suren Sooranna, Hengguo Li, Jian Song, Jian Song   +14 more
doaj   +1 more source

Parkinson's Disease and Systemic Inflammation [PDF]

Parkinson's Disease, 2011
Peripheral inflammation triggers exacerbation in the central brain's ongoing damage in several neurodegenerative diseases. Systemic inflammatory stimulus induce a general response known as sickness behaviour, indicating that a peripheral stimulus can induce the synthesis of cytokines in the brain.
Carina C. Ferrari, Rodolfo Tarelli
openaire   +3 more sources

The Impact of Systemic Inflammation on Neurodevelopment [PDF]

Trends in Molecular Medicine, 2018
Inflammatory mediators affect the brain during development. Neurodevelopmental disorders such as autism spectrum disorders, cognitive impairment, cerebral palsy, epilepsy, and schizophrenia have been linked to early life inflammation. Recent advances have shown the effects of systemic inflammation on children's neurodevelopment.
Nona M, Jiang, Maureen, Cowan, Shannon N, Moonah, William A, Petri   +3 more
openaire   +2 more sources