Results 31 to 40 of about 936,764 (268)

Fcγ Receptor IIB Controls Skin Inflammation in an Active Model of Epidermolysis Bullosa Acquisita

Frontiers in Immunology, 2020
Epidermolysis bullosa acquisita (EBA) is an autoimmune skin blistering disease characterized by IgG autoantibodies (aAb) against type VII collagen (COL7).
Balint Kovacs, Balint Kovacs, Jenny Tillmann, Lisa-Christin Freund, Falk Nimmerjahn, Christian D. Sadik, Katja Bieber, Ralf J. Ludwig, Christian M. Karsten, Jörg Köhl, Jörg Köhl   +10 more
doaj   +1 more source

The Identification of a Tumor Infiltration CD8+ T-Cell Gene Signature That Can Potentially Improve the Prognosis and Prediction of Immunization Responses in Papillary Renal Cell Carcinoma

Frontiers in Oncology, 2021
BackgroundCD8+ T cells, vital effectors pertaining to adaptive immunity, display close relationships to the immunization responses to kill tumor cells. Understanding the effect exerted by tumor infiltration CD8+ T cells in papillary renal cell carcinoma (
Jie Wang, Jie Wang, Meiying Huang, Meiying Huang, Peng Huang, Jingjie Zhao, Junhua Tan, Feifan Huang, Ruiying Ma, Yu Xiao, Gao Deng, Liuzhi Wei, Liuzhi Wei, Qiuju Wei, Qiuju Wei, Zechen Wang, Siyuan He, Jiajia Shen, Suren Sooranna, Lingzhang Meng, Jian Song, Jian Song   +21 more
doaj   +1 more source

Transcriptome Profiling Reveals B-Lineage Cells Contribute to the Poor Prognosis and Metastasis of Clear Cell Renal Cell Carcinoma

Frontiers in Oncology, 2021
Although immune therapy can improve the treatment of clear cell renal cell carcinoma (ccRCC) significantly, there are still a large proportion of ccRCC patients who progress to metastasis.
Fafen Yang, Fafen Yang, Jingjie Zhao, Xiuzhuang Luo, Tong Li, Tong Li, Zechen Wang, Qiuju Wei, Qiuju Wei, Heming Lu, Yiliang Meng, Kai Cai, Liuying Lu, Yushi Lu, Lifen Chen, Suren Rao Sooranna, Linxue Luo, Linxue Luo, Jian Song, Jian Song, Lingzhang Meng   +20 more
doaj   +1 more source

Intestinal flora induces depression by mediating the dysregulation of cerebral cortex gene expression and regulating the metabolism of stroke patients

Frontiers in Molecular Biosciences, 2022
Post-stroke depression (PSD) is a common cerebrovascular complication characterized by complex pathogenesis and poor treatment effects. Here, we tested the influence of differentially expressed genes (DEGs), non-targeted metabolites, and intestinal ...
Xuebin Li, Xuebin Li, Guangshun Han, Jingjie Zhao, Xiaohua Huang, Yun Feng, Junfang Huang, Xuequn Lan, Xiaorui Huang, Zechen Wang, Jiajia Shen, Siyuan He, Qiuhao Li, Jian Song, Jian Song, Jie Wang, Jie Wang, Lingzhang Meng, Lingzhang Meng   +18 more
doaj   +1 more source

Overall Structural Alteration of Gut Microbiota and Relationships with Risk Factors in Patients with Metabolic Syndrome Treated with Inulin Alone and with Other Agents: An Open-Label Pilot Study

Mediators of Inflammation, 2022
Objective. The relative contribution of some products with prebiotic effects, such as inulin, together with medications specific to the human gut microbiome has not been comprehensively studied. The present study determined the potential for manipulating
Ruiping Tian, Jiahui Hong, Jingjie Zhao, Dengyuan Zhou, Yangchen Liu, Zhenshan Jiao, Jian Song, Yu Zhang, Lingzhang Meng, Ming Yu   +9 more
doaj   +1 more source

Complement Has Brains—Do Intracellular Complement and Immunometabolism Cooperate in Tissue Homeostasis and Behavior?

Frontiers in Immunology, 2021
The classical liver-derived and serum-effective complement system is well appreciated as a key mediator of host protection via instruction of innate and adaptive immunity.
Natalia Kunz, Claudia Kemper, Claudia Kemper   +2 more
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Infection and inflammation and the coagulation system [PDF]

Cardiovascular Research, 2003
Severe infection and inflammation almost invariably lead to hemostatic abnormalities, ranging from insignificant laboratory changes to severe disseminated intravascular coagulation (DIC). Systemic inflammation results in activation of coagulation, due to tissue factor-mediated thrombin generation, downregulation of physiological anticoagulant ...
Levi, M., Keller, T.T., Gorp, E. van, Cate, H. ten   +3 more
openaire   +3 more sources

ADAM-10 Regulates MMP-12 during Lipopolysaccharide-Induced Inflammatory Response in Macrophages

Journal of Immunology Research, 2022
A disintegrin and metalloprotease 10 (ADAM-10), a member of the ADAM protease family, has biological activities related to TNF-α activation, cell adhesion, and migration, among other functions.
Yan Jiang, Qiming Gong, Jinmei Huang, Yuanxun Gong, Qiang Tang, Dalong Wei, Qianli Tang, Jingjie Zhao, Jian Song, Lingzhang Meng   +9 more
doaj   +1 more source

S100A9 Derived From Myeloma Associated Myeloid Cells Promotes TNFSF13B/TNFRSF13B-Dependent Proliferation and Survival of Myeloma Cells

Frontiers in Oncology, 2021
Multiple myeloma (MM) is a lethal hematological malignancy characterized by abundant myeloid cells in the microenvironment that fuel tumor progression. But the mechanism by which myeloid cells support myeloma cells has not been fully explored.
Lingzhang Meng, Lingzhang Meng, Qiang Tang, Jingjie Zhao, Zechen Wang, Liuzhi Wei, Liuzhi Wei, Qiuju Wei, Qiuju Wei, Lianfei Yin, Shiguan Luo, Jian Song, Jian Song   +12 more
doaj   +1 more source

Tumor-Infiltrated CD8+ T Cell 10-Gene Signature Related to Clear Cell Renal Cell Carcinoma Prognosis

Frontiers in Immunology, 2022
Clear cell renal cell carcinoma (ccRCC) usually affects multiple organs (e.g., bone and brain), and patient prognosis is usually poor. Although it is known that CD8+ T cell infiltration can potentially alleviate ccRCC progression, few studies have ...
Jie Wang, Jie Wang, Feifan Huang, Jingjie Zhao, Peng Huang, Junhua Tan, Meiying Huang, Ruiying Ma, Yu Xiao, Siyuan He, Zechen Wang, Jiajia Shen, Heming Lu, Lingzhang Meng, Lingzhang Meng   +14 more
doaj   +1 more source