Results 51 to 60 of about 11,089,212 (272)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Systemic Inflammatory Response Syndrome and Mechanical Circulatory Support Devices [PDF]

, 2022
Systemic inflammatory response syndrome is an increased inflammatory state affecting the whole body. Mechanical circulatory support (MCS) is a temporary or permanent form of extracorporeal support that may have an associated complication of an ...
Mihu, Mircea R, El-Banayosy, Aly
core   +1 more source

Systemic Immune-Inflammatory Index and Systemic Inflammatory Response Index in the Assessment of Multiple Organ Dysfunction Syndrome Caused by Wasp Stings

Journal of Inflammation Research
This study aims to assess the prognosis of patients with multiple organ dysfunction syndrome (MODS) caused by wasp stings by analyzing early systemic immune inflammation index (SII) and systemic inflammation response index (SIRI) values.A retrospective analysis was conducted on 151 patients admitted to the Department of Emergency Medicine, Taihe ...
Xiaolin Zhang, Pengfei Liang, Chi Tong, Wentao Tao, Li Zhang, Juan Zhao, Zhicheng Fang, Zhiwen Zhao   +7 more
openaire   +3 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Association of SII and AISI in patients with sepsis: A retrospective study

Medicine Science
Sepsis, a life-threatening dysregulated immune response to infection, necessitates reliable biomarkers for early risk stratification and prognosis. Sepsis occurs when bacteria that cause an infection the body's overwhelming inflammatory reaction to ...
Ahmet Burak Gurpinar, Huseyin Erdal, Hacer Ozlem Kalayci   +2 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

IgG anti-apolipoprotein A-1 antibodies in patients with systemic lupus erythematosus are associated with disease activity and corticosteroid therapy: an observational study. [PDF]

, 2015
IgG anti-apolipoprotein A-1 (IgG anti-apoA-1) antibodies are present in patients with systemic lupus erythematosus (SLE) and may link inflammatory disease activity and the increased risk of developing atherosclerosis and cardiovascular disease (CVD) in ...
Davari, M, Yiannis Ioannou, Isenberg, D, Paul Bassett, Rahman, A, David Isenberg, Anisur Rahman, Maria Davari, Alber, KF, Ioannou, Y, Oliver Leach, Giles, I, Bassett, P, Karim Alber, Ian Giles, Leach, O, Sara Croca, Chambers, S, Croca, S, Sharon Chambers   +19 more
core   +1 more source

Effect of Systemic Inflammatory Response Index (SIRI) and Systemic Immuno-Inflammation Index (SII) on mortality in heart failure patients

Romanian Journal of Laboratory Medicine
Heart failure (HF) is a structural and functional disease that affects millions of people worldwide. The role of inflammation has been demonstrated in many diseases.
Bedel Cihan, Selvi Fatih, Zortuk Ökkeş, Yildiz Gunay, Yavuz Yavuz Fatih, Korkut Mustafa   +5 more
doaj   +1 more source

Clinical Utility of Systemic Immune-inflammatory Index and Systemic Immune Response Index in Symptomatic Patients with Hashimoto's Thyroiditis

Haseki Tıp Bülteni
Aim: Systemic immune-inflammatory indices have recently been investigated as potential biomarkers in several inflammatory and autoimmune diseases. This study aimed to investigate the symptom-based diagnostic value of the systemic immuno-inflammatory ...
Arzu Gunturk, Muzeyyen Eryilmaz
doaj   +1 more source