Results 31 to 40 of about 736,102 (303)

Discovery of a Highly Potent, Selective, and Metabolically Stable Inhibitor of Receptor-Interacting Protein 1 (RIP1) for the Treatment of Systemic Inflammatory Response Syndrome.

Journal of Medicinal Chemistry, 2017
On the basis of its essential role in driving inflammation and disease pathology, cell necrosis has gradually been verified as a promising therapeutic target for treating atherosclerosis, systemic inflammatory response syndrome (SIRS), and ischemia ...
Yan Ren, Yaning Su, Liming Sun, Sudan He, Lingjun Meng, Daohong Liao, Xiao Liu, Yongfen Ma, Chunyan Liu, Sisi Li, Hanying Ruan, Xiaoguang Lei, Xiaodong Wang, Zhiyuan Zhang   +13 more
semanticscholar   +1 more source

Adjunctive Therapeutic Plasma Exchange in Refractory Adult‐Onset Still's Disease Complicated by Secondary Macrophage Activation Syndrome: A Single‐Center Experience

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Adult‐onset Still's disease (AOSD) complicated by macrophage activation syndrome (MAS) carries substantial mortality. The role of therapeutic plasma exchange (TPE) remains uncertain. Methods We retrospectively analyzed patients with AOSD‐MAS treated with TPE at a single‐center.
Masataka Ueda, Tomohiro Saito, Masahide Mizobuchi, Tomoki Shimomura, Saki Kawamori, Mitsuru Kawanishi, Natsuko Hattori, Jo Sugiyama, Satoshi Tsubata, Hanami Horiguchi, Kazuki Abe, Nao Iida, Yuki Kajio, Nao Oguro, Ryo Yanai, Hirokazu Honda   +15 more
wiley   +1 more source

Prognostic Value and Development of a Scoring System in Horses With Systemic Inflammatory Response Syndrome

Journal of Veterinary Internal Medicine, 2017
Background Despite its widespread use in equine medicine, the clinical value of the systemic inflammatory response syndrome (SIRS) concept in horses remains unknown.
M. Roy, G. Kwong, J. Lambert, S. Massie, S. Lockhart   +4 more
semanticscholar   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Procalcitonin, Interleukin-1, Interleukin-10, Interleukin-13 and Tumor necrosis factor-alpha predictive value in the diagnosis of sepsis [PDF]

Kirkuk Journal of Science, 2017
The present study is aimed to evaluate the role of some markers in the diagnosis of sepsis among SIRS (systemic inflammatory response syndrome) patients. The study included 180 patients with SIRS criteria within 24 hour of admission.
Ansam Mohammad H, Zainalabdeen A. Abdulla   +1 more
doaj   +1 more source

Evaluation of Parameters Affecting the Occurrence of Systemic Inflammatory Response Syndrome in Patients Operated on Due to Kidney Tumors

Biomedicines, 2023
The application and prognostic nature of systemic inflammatory reaction syndrome (SIRS) is still being researched, as using SIRS parameters to predict patient status is cheap, efficient, fast, and easy.
Mateusz Marcinek, Michał Tkocz, Kamil Marczewski, Robert Partyka, Leszek Kukulski, Krystyna Młynarek-Śnieżek, Bogumiła Sędziak-Marcinek, Paweł Rajwa, Adam Berezowski, Danuta Kokocińska   +9 more
doaj   +1 more source

Time to Recognition of Sepsis in the Emergency Department Using Electronic Health Record Data: A Comparative Analysis of Systemic Inflammatory Response Syndrome, Sequential Organ Failure Assessment, and Quick Sequential Organ Failure Assessment.

Critical Care Medicine, 2019
OBJECTIVES Early identification of sepsis is critical to improving patient outcomes. Impact of the new sepsis definition (Sepsis-3) on timing of recognition in the emergency department has not been evaluated.
P. Prasad, M. Fang, Yumiko Abe-Jones, C. Calfee, M. Matthay, K. Kangelaris   +5 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Thrombectomy in patients with basilar artery thrombosis

Неотложная медицинская помощь, 2021
Introduction. This article is devoted to the discussion of a life-threatening condition - basilar artery thrombosis (BAT). The article presents the results of a comparative analysis of two groups of patients with angiographically confirmed BAT: with and ...
G. R. Ramazanov, E. A. Kovaleva, E. V. Klychnikova, L. S. Kokov, H. V. Korigova, R. Sh. Muslimov, M. V. Parkhomenko, S. S. Petrikov, V. N. Stepanov   +8 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source