Tubulointerstitial nephritis and uveitis syndrome in children: What to keep an eye on
Abstract Purpose The purpose of this study was to determine the disease course in patients with tubulointerstitial nephritis and uveitis (TINU) syndrome, focusing on long‐term outcome and the incidence of complications such as chronic kidney disease (CKD).
Jytte Hendrikse +4 more
wiley +1 more source
Juvenile idiopathic arthritis in two tertiary centres in the Western Cape, South Africa [PDF]
The original publication is available at http://www.ped-rheum.com/content/10/1/35BibliographyBACKGROUND: Juvenile idiopathic arthritis (JIA) is a disease that shows wide variations between differing populations.
Kate Weakley +2 more
core +2 more sources
Novel approaches for drug development against chronic primary pain: A systematic review
Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
How Do Dental Professionals and Students Assess Orthodontic Case Complexity?
ABSTRACT Background Accurately diagnosing and assessing orthodontic case complexity is essential for treatment planning, estimating therapy duration, and determining required expertise. Various indices, such as the American Board of Orthodontics Discrepancy Index (ABO DI), provide objective evaluations.
Giulia Semerari +4 more
wiley +1 more source
The presence of high mobility group box-1 and soluble receptor for advanced glycation end-products in juvenile idiopathic arthritis and juvenile systemic lupus erythematosus [PDF]
BACKGROUND: The involvement of high mobility group box-1 (HMGB1) in various inflammatory and autoimmune diseases has been documented but clinical trials on the contribution of this pro-inflammatory alarmin in children with juvenile idiopathic ...
Bobek, Dubravka +4 more
core +1 more source
Bronchiolitis obliterans. [PDF]
Bronchiolitis obliterans in the adult patient is a relatively uncommon and vexing clinical entity. This confusion results because this pathologic finding occurs in a variety of diverse clinical settings.
King, TE
core
ABSTRACT Introduction D‐dimers are produced by lysis of cross‐linked fibrin. In children, D‐dimer testing is used to evaluate disseminated intravascular coagulation (DIC) and some inflammatory states, but its use is not validated for screening or ruling out suspected venous thromboembolic events (VTE).
Rabab Al Dawood +4 more
wiley +1 more source
Role of interleukin-17 in juvenile idiopathic arthritis
Joint diseases is a pressing problem of pediatrics. Juvenile idiopathic arthritis is a common chronic systemic inflammatory disease of the joints in children; its etiological factors remain completely unknown.
I.A. Karimdzhanov, M.Sh. Madaminova
doaj +1 more source
Treatment of a class 2 skeletal malocclusion with degenerative arthritis of the condyles using custom-made temporomandibular joint replacements and genioplasty [PDF]
This case report presents the use of custom-made temporomandibular joint prostheses in the treatment of a class 2 malocclusion secondary to juvenile idiopathic arthritis. The patient had degeneration of the mandibular condyles with associated arthropathy
Laverick, Sean +4 more
core +2 more sources
A constant rate of DNA damage that is not perfectly repaired will cause a constant rate of DNA mutations. The chance of mutation will increase if DNA is prone to damage, such as occurs in somatic hypermutation (SHM) hotspots and GC‐rich DNA. Thus, if one mutation‐prone DNA site drives disease, the age of onset of disease and degree of penetrance should
Piet C. de Groen
wiley +1 more source

