Results 91 to 100 of about 66,314 (265)

Next Generation Sequencing of Genes With Epigenetic Alterations in Mastocytosis

Clinical and Translational Allergy, Volume 15, Issue 10, October 2025.
ABSTRACT Aim Mastocytosis is a neoplastic disease of the bone marrow associated with the risk of frequent and severe allergic reactions. However, the genetic predisposition is not fully understood, and the crucial element in pathogenesis is the presence of the oncogenic KIT p. D816 V gene mutation.
Aleksandra Górska, Thierry van De Wetering, Marta Sobalska‐Kwapis, Bogusław Nedoszytko, Danuta Gutowska‐Owsiak, Marek Niedoszytko   +5 more
wiley   +1 more source

Avapritinib treatment of aggressive systemic mastocytosis with a novel KIT exon 17 mutation

Leukemia Research Reports
Background: Systemic mastocytosis is a rare hematologic malignancy that leads to the accumulation of neoplastic mast cells in the bone marrow, visceral organs, and skin.
Lyndsey Sandow, Ajia Town, Michael C. Heinrich   +2 more
doaj   +1 more source

A Phase 2 study of CPX‐351 in combination with venetoclax in patients with newly diagnosed high‐risk acute myeloid leukemia

HemaSphere, Volume 9, Issue 10, October 2025.
Abstract Venetoclax has been combined with intensive chemotherapy regimens in the treatment of acute myeloid leukemia (AML). We aimed to investigate the safety and efficacy of venetoclax combined with full‐dose CPX‐351 (CPX + VEN) in newly diagnosed (ND) AML.
Wei‐Ying Jen, Jennifer Croden, Emmanuel Almanza‐Huante, Courtney DiNardo, Kelly Chien, Danielle Hammond, Wei Qiao, Yesid Alvarado, Lucia Masarova, Andres E. Quesada, Sherry Pierce, Alex Bataller, Guillermo Garcia‐Manero, Amin Alousi, Nicholas Short, Naval Daver, Farhad Ravandi, Hagop Kantarjian, Tapan M. Kadia   +18 more
wiley   +1 more source

SEVERE OSTEOPOROSIS DUE TO SYSTEMIC MAST CELL DISEASE: SUCCESSFUL TREATMENT WITH INTERFERON ALPHA-2B [PDF]

, 2017
We describe a 33-yr-old man suffering from severe vertebral osteoporosis and urticaria pigmentosa due to systemic mast cell disease (SMCD). Because i.v.
BEYELER, C., DAHINDEN, C., GERBER, N. J., HUNZIKER, T., LEHMANN, T., LÄMMLE, B., OLAH, A. J., VOCK, P.   +7 more
core  

Mast cell-related disorders presenting with Kounis syndrome [PDF]

, 2016
Letter to the Editor.-- et al.Peer ...
Escribano, Luis, García-Montero, Andrés, Gonzalez-de-Olano, David, Jara-Acevedo, Maria, Matito, Almudena, Morgado, J. M., Orfao, Alberto, Sánchez-Muñoz, Laura, Teodosio, Cristina, Álvarez-Twose, Iván   +9 more
core   +1 more source

A Growing Concern for Cashew and an Unexpected Risk From Almonds: Data From the Anaphylaxis Registry

Allergy, Volume 80, Issue 10, Page 2837-2848, October 2025.
Tree nut‐induced anaphylaxis constitutes 23% of food‐induced anaphylaxis among the anaphylaxis registry. Confirmed elicitors differed between children (n = 845) and adults (n = 238): cashew, hazelnut, and walnut were most frequent among children, while hazelnut, walnut, and almond were most frequent among adults.
Veronika Höfer, Sabine Dölle‐Bierke, Dominique Sabouraud‐Leclerc, Amandine Divaret‐Chauveau, Alice Köhli, Maria Breiding, Karin Hartmann, Lars Lange, Nikolaos Papadopoulos, Hagen Ott, Stephanie Hompes, Maria Beatrice Bilò, Blanca E. García, Margitta Worm   +13 more
wiley   +1 more source

Value of urinary N-methylhistamine measurements m childhood mastocytosis [PDF]

, 1996
Background: Histamine is an indicator of mast cell activation. N- methylhistamine (NMH) is a metabolite of histamine that can be measured in urine. Objective: Our purpose was to assess the usefulness of determining urinary NMH levels for the diagnosis ...
De Lijster De Raadt, J. (Jacqueline), Gysel, D. (Dirk) van, Mulder, P.G.H. (Paul), Oranje, A.P. (Arnold), Toorenenbergen, A.W. (Albert) van, Vermeiden, I. (Ida)   +5 more
core   +1 more source

Treatment Approaches for Diffuse Cutaneous Mastocytosis in Children: Literature Review and Actual Clinical Experience

Вопросы современной педиатрии
Background. Mastocytosis is a very rare disease with various manifestations, based on abnormal clonal proliferation of mast cells in organs and tissues, such as: skin, bone marrow, lymph nodes, liver, spleen, and gastrointestinal tract. The diagnosis can
Timur T. Valiev, Nikolay N. Murashkin, Tatiana S. Belysheva, Zarina G. Misikova, Daria A. Pronina, Roman V. Epishev, Roman A. Ivanov   +6 more
doaj   +1 more source

Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy

Haematologica, 2014
Chronic myeloid leukemia and systemic mastocytosis are myeloid neoplasms sharing a number of pathogenetic and clinical features. In both conditions, an aberrantly activated oncoprotein with tyrosine kinase activity, namely BCR-ABL1 in chronic myeloid ...
Siham Bibi, Melis Dilara Arslanhan, Florent Langenfeld, Sylvie Jeanningros, Sabine Cerny-Reiterer, Emir Hadzijusufovic, Luba Tchertanov, Richard Moriggl, Peter Valent, Michel Arock   +9 more
doaj   +1 more source

Routine abdominal ultrasonography has limited value in the care for patients with indolent systemic mastocytosis [PDF]

, 2017
Objectives: Systemic mastocytosis (SM) is a myeloproliferative disease characterized by the accumulation of aberrant mast cells. Since advanced subtypes of SM can lead to organ dysfunction and shortened survival, timely recognition of progressive disease
Daele, P.L.A. (Paul) van, de Mol, C.L., Gerth van Wijk, R. (Roy), Hagen, P.M. (Martin) van, Hermans, M.A.W. (Maud A.W.)   +4 more
core   +2 more sources