Results 71 to 80 of about 68,714 (217)

Multiple large osteolytic lesions in a patient with systemic mastocytosis: a challenging diagnosis

Clinical Case Reports, 2017
Key Clinical Message Patients with advanced variants of Systemic Mastocytosis may develop destructive bone lesions when massive mast cell (MC) infiltrates are present. Finding of large osteolyses in indolent systemic mastocytosis, typically characterized
Massimiliano Bonifacio, Roberta Zanotti, Emanuele Guardalben, Elda Mimiola, Francesca Scognamiglio, Omar Perbellini, Giovanna De Matteis, Luis Escribano, Patrizia Bonadonna, Daniela Grigolato, Sergio Bissoli, Alice Parisi, Alberto Zamò, Achille Ambrosetti, Maurizio Rossini   +14 more
doaj   +1 more source

Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis

Haematologica, 2011
Cooperating genetic events are likely to contribute to the phenotypic diversity of KIT-D816V systemic mastocytosis. In this study, 44 patients with KIT-D816V systemic mastocytosis were evaluated for coexisting NRAS, KRAS, HRAS or MRAS mutations ...
Todd M. Wilson, Irina Maric, Olga Simakova, Yun Bai, Eunice Ching Chan, Nicolas Olivares, Melody Carter, Dragan Maric, Jamie Robyn, Dean D. Metcalfe   +9 more
doaj   +1 more source

Trüptaasi füsioloogiline ja kliiniline tähendus [PDF]

, 2006
Trüptaas on oluline mediaator, mis vabaneb nuumrakkude aktivatsioonil põletikuliste ja allergiliste reaktsioonide korral. Trüptaasi sisalduse suurenemine esineb 1–6 tundi pärast süsteemset anafülaktilist reaktsiooni, mis võimaldab kasutada trüptaasi ...
Velbri, Sirje
core   +2 more sources

Avapritinib treatment of aggressive systemic mastocytosis with a novel KIT exon 17 mutation

Leukemia Research Reports
Background: Systemic mastocytosis is a rare hematologic malignancy that leads to the accumulation of neoplastic mast cells in the bone marrow, visceral organs, and skin.
Lyndsey Sandow, Ajia Town, Michael C. Heinrich   +2 more
doaj   +1 more source

Kounis Syndrome Associated With Selective Anaphylaxis to Cefazolin. [PDF]

, 2018
info:eu-repo/semantics ...
Chambel, M, Correia, M, Gaspar, A, Morais-Almeida, M, Mota, I, Sequeira, T   +5 more
core   +1 more source

Schwann Cell TRPA1, a Proalgesic Ion Channel, Mediates Neuroinflammation and Fibromyalgia‐Associated Behaviours in Mice

Journal of Neurochemistry, Volume 170, Issue 4, April 2026.
Cellular and molecular mechanisms contributing to TRPA1‐mediated mechanical and cold hypersensitivity and peripheral neuroinflammation in the reserpine‐induced experimental fibromyalgia model. (1) Macrophage‐originated reactive oxygen species (ROS; purple dots) target the transient receptor potential ankyrin 1 (TRPA1) channel localised in Schwann cells.
Evelyne Silva Brum, Maria Fernanda Pessano Fialho, Daniel Souza Monteiro de Araújo, Lorenzo Landini, Matilde Marini, Francesco De Logu, Romina Nassini, Sara Marchesan Oliveira   +7 more
wiley   +1 more source

The Basophil Activation Test Is Not a Useful Screening Tool for Hymenoptera Venom-Related Anaphylaxis in Patients with Systemic Mastocytosis [PDF]

, 2016
Background: Systemic mastocytosis (SM) patients are at a high risk for anaphylaxis, with Hymenoptera as the main culprit. A screening instrument to identify which patients are sensitized to Hymenoptera before they experience anaphylaxis would therefore ...
Daele, P.L.A. (Paul) van, Gerth van Wijk, R. (Roy), Hermans, M.A.W. (Maud A.W.), Rietveld, M.J.A. (Mark J.A.), Schreurs, M.W.J. (Marco)   +4 more
core   +1 more source

A Link Between Allergy and Hematological Malignancies? Focus on Possible Mechanisms and the Potential Role of Biological Therapies

Clinical and Translational Allergy, Volume 16, Issue 3, March 2026.
ABSTRACT Immune dysregulation has been widely recognized in the international literature as an underlying condition for hematological malignancies and allergic disorders. This commonality has led researchers to study the potential association, positive or negative, between blood cancers and allergy, but the results remain unclear.
Stefania Isola, Luca Gammeri, Federica Nuccio, Alessandro Allegra, Giorgio Walter Canonica, Sebastiano Gangemi   +5 more
wiley   +1 more source

Mast cell-related disorders presenting with Kounis syndrome [PDF]

, 2016
Letter to the Editor.-- et al.Peer ...
Escribano, Luis, García-Montero, Andrés, Gonzalez-de-Olano, David, Jara-Acevedo, Maria, Matito, Almudena, Morgado, J. M., Orfao, Alberto, Sánchez-Muñoz, Laura, Teodosio, Cristina, Álvarez-Twose, Iván   +9 more
core   +1 more source

Extent and Incidence of Pseudo‐Worsening of Kidney Function Due to Oral Antitumor Therapeutics in the AMBORA Cohort: An Analysis of Real‐World Data

Clinical Pharmacology &Therapeutics, Volume 119, Issue 3, Page 802-811, March 2026.
A considerable number of oral antitumor therapeutics (OAT) has the potential for causing pseudo‐worsening of kidney function (PW) due to inhibition of renal creatinine secretion, i.e., kidney function is unaffected, while creatinine‐based calculation of glomerular filtration rate (eGFR) erroneously indicates an impaired kidney function.
Michael I. Sponfeldner, Pauline Dürr, Phyllis Lensker, Katja Gessner, Lisa Cuba, Rainer Fietkau, Markus F. Neurath, Bernd Wullich, Marianne Pavel, Carola Berking, Matthias W. Beckmann, Andreas Mackensen, Frank Dörje, Martin F. Fromm   +13 more
wiley   +1 more source