Results 51 to 60 of about 64,256 (179)

Multiple large osteolytic lesions in a patient with systemic mastocytosis: a challenging diagnosis

Clinical Case Reports, 2017
Key Clinical Message Patients with advanced variants of Systemic Mastocytosis may develop destructive bone lesions when massive mast cell (MC) infiltrates are present. Finding of large osteolyses in indolent systemic mastocytosis, typically characterized
Massimiliano Bonifacio, Roberta Zanotti, Emanuele Guardalben, Elda Mimiola, Francesca Scognamiglio, Omar Perbellini, Giovanna De Matteis, Luis Escribano, Patrizia Bonadonna, Daniela Grigolato, Sergio Bissoli, Alice Parisi, Alberto Zamò, Achille Ambrosetti, Maurizio Rossini   +14 more
doaj   +1 more source

Clonal analysis of NRAS activating mutations in KIT-D816V systemic mastocytosis

Haematologica, 2011
Cooperating genetic events are likely to contribute to the phenotypic diversity of KIT-D816V systemic mastocytosis. In this study, 44 patients with KIT-D816V systemic mastocytosis were evaluated for coexisting NRAS, KRAS, HRAS or MRAS mutations ...
Todd M. Wilson, Irina Maric, Olga Simakova, Yun Bai, Eunice Ching Chan, Nicolas Olivares, Melody Carter, Dragan Maric, Jamie Robyn, Dean D. Metcalfe   +9 more
doaj   +1 more source

Role of Cysteinyl Leukotrienes in Food Allergy and Anaphylaxis: A Potential Therapeutic Target

Allergy, EarlyView.
Adrienn Weingärtner, Thomas Eiwegger
wiley   +1 more source

European S2k guidelines on management of autoimmune blistering diseases in children and adolescents

Journal of the European Academy of Dermatology and Venereology, Volume 40, Issue 7, Page 1137-1161, July 2026.
Autoimmune blistering disorders (AIBDs) in children are rare, challenging to diagnose and treat and often require immunosuppressants. Until now, no paediatric care guidelines existed. The EADV Task Force for AIBDs has developed the consensus‐based recommendations, enabling physicians to adopt a uniform, tailored treatment strategy to improve outcomes ...
A. Nanda, B. Tedbirt, C. Bodemer, M. C. Bolling, M. El Hachem, M. Nikolić, E. Benton, M. Caproni, D. De, D. Didona, K. Drenovska, M. Goebeler, M. Hertl, B. Horváth, M. Kasperkiewicz, D. Kiritsi, M. Larralde, A. V. Marzano, J. Meijer, D. F. Murrell, J. Powell, E. Sprecher, N. S. Chandran, M. M. Tomayko, S. Uzun, N. van Beek, H. Ott, A. Patsatsi, A. Torrelo, A. Welfringer‐Morin, E. Schmidt, P. Joly   +31 more
wiley   +1 more source

Avapritinib treatment of aggressive systemic mastocytosis with a novel KIT exon 17 mutation

Leukemia Research Reports
Background: Systemic mastocytosis is a rare hematologic malignancy that leads to the accumulation of neoplastic mast cells in the bone marrow, visceral organs, and skin.
Lyndsey Sandow, Ajia Town, Michael C. Heinrich   +2 more
doaj   +1 more source

Fire ant-venom anaphylaxis prevalence in the general population and patients with systemic mastocytosis

Frontiers in Allergy
BackgroundStinging Hymenoptera can induce fatal anaphylaxis, especially in patients with systemic mastocytosis. Fire ants, Solenopsis invicta and S. richteri, from South America have recently colonized three continents.
Jeremy C. McMurray, Jeremy C. McMurray, Brandon J. Schornack, Brandon J. Schornack, Karla E. Adams, Robert L. McCoy, Amanda K. Marshall, Janet A. Brunader, Irina Maric, Dean D. Metcalfe, Nathan A. Boggs, Nathan A. Boggs   +11 more
doaj   +1 more source

Breakthrough reactions in pediatric chemotherapeutic desensitization: Outcomes and associated risk factors

Pediatric Allergy and Immunology, Volume 37, Issue 7, July 2026.
Breakthrough reactions in Pediatric chemotherapeutic desensitization: outcomes and associated risk factors. Abstract Background Rapid drug desensitization (RDD) enables the safe reintroduction of chemotherapeutic agents in patients with hypersensitivity reactions (HSRs).
Pathitta Doradee, Supaluk Tangvalelerd, Kantima Kanchanapoomi, Prapasri Kulalert, Punchama Pacharn, Orathai Jirapongsananuruk, Witchaya Srisuwatchari   +6 more
wiley   +1 more source

Kinetic Fingerprints as Mechanistic and Clinical Roadmaps Across KIT Activation States

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
Kinetic profiling of 172 compounds across KIT conformations—including D816V—reveals kinetic fingerprints that predict efficacy, selectivity, resistance, and inhibitors’ ability to stabilize key regulatory elements. Far from a secondary metric, binding kinetics provide mechanistic insights beyond affinity, offering a powerful framework for rational drug
Ana Corrionero, Niall Prendiville, Tatiana Cazorla, Maria Baena‐Nuevo, Röhm Sandra, Emilio Camafeita, Stefan Knapp, Patricia Alfonso   +7 more
wiley   +1 more source

Treatment Approaches for Diffuse Cutaneous Mastocytosis in Children: Literature Review and Actual Clinical Experience

Вопросы современной педиатрии
Background. Mastocytosis is a very rare disease with various manifestations, based on abnormal clonal proliferation of mast cells in organs and tissues, such as: skin, bone marrow, lymph nodes, liver, spleen, and gastrointestinal tract. The diagnosis can
Timur T. Valiev, Nikolay N. Murashkin, Tatiana S. Belysheva, Zarina G. Misikova, Daria A. Pronina, Roman V. Epishev, Roman A. Ivanov   +6 more
doaj   +1 more source

Co-operating STAT5 and AKT signaling pathways in chronic myeloid leukemia and mastocytosis: possible new targets of therapy

Haematologica, 2014
Chronic myeloid leukemia and systemic mastocytosis are myeloid neoplasms sharing a number of pathogenetic and clinical features. In both conditions, an aberrantly activated oncoprotein with tyrosine kinase activity, namely BCR-ABL1 in chronic myeloid ...
Siham Bibi, Melis Dilara Arslanhan, Florent Langenfeld, Sylvie Jeanningros, Sabine Cerny-Reiterer, Emir Hadzijusufovic, Luba Tchertanov, Richard Moriggl, Peter Valent, Michel Arock   +9 more
doaj   +1 more source