Results 51 to 60 of about 978,166 (202)

Updated EAACI Statement on Drug Hypersensitivity Skin Testing: Methodology and Non‐Irritative Concentrations

Allergy, EarlyView.
ABSTRACT These updated EAACI guidelines aim to standardize skin testing methodologies for both immediate and non‐immediate drug hypersensitivity reactions. For immediate reactions, the optimal testing window is 4–6 weeks post‐reaction; whereas beyond 6 months, false‐negative results increase.
Annick Barbaud, Lene Heise Garvey, Elizabeth Phillips, Michael Ardern‐Jones, Sevim Bavbek, Patrizia Bonadonna, Jean‐Christoph Caubet, Ana‐Maria Copaescu, Valentina Gueli, Jose Julio Laguna, Ricardo Madrigal‐Burgaleta, Francesca Mori, Vito Sabato, Maria J Torres, Knut Brockow   +14 more
wiley   +1 more source

Comprehensive mastocytosis data analysis from a single center

BMC Cancer, 2023
Mastocytosis is a very rare disorder and is divided into three prognostically distinct variants by World Health Organization: Cutaneous mastocytosis (CM), systemic mastocytosis (SM), and mast cell sarcoma or localized mast cell (MC) tumors.
Tarık Onur Tiryaki, Sıdıka Gülkan Özkan, Simge Erdem, Aynur Dağlar Aday, İpek Yönal Hindilerden, Aslı Gelincik, Can Baykal, Gülçin Yegen, İbrahim Öner Doğan, Nesimi Büyükbabani, Meliha Nalçacı, Akif Selim Yavuz   +11 more
doaj   +1 more source

Acquired von Willebrand syndrome associated with indolent systemic mastocytosis [PDF]

, 2020
Hereby we present case report of acquired von Willebrand syndrome (AVWS) in patient with indolent systemic mastocytosis (ISM). Systemic mastocytosis may be considered as a model disease for development of AVWS.
Majeranowski, Alan; Department of Hematology and Transplantology, Medical University of Gdansk, Czarnogórski, Michał; Department of Hematology and Transplantology, Medical University of Gdansk, Janowiak-Majeranowska, Aleksandra; Department of Otolaryngology, Medical University of Gdansk, Mital, Andrzej; Department of Hematology and Transplantology, Medical University of Gdansk, Zawilski, Janusz; Diagnostic and Therapeutic Center InterLab in Poznan, Aleksandra Janowiak-Majeranowska, Andrzej Mital, Alan Majeranowski, Janusz Zawilski, Michał Czarnogórski   +9 more
core   +1 more source

Molecular quantification of tissue disease burden is a new biomarker and independent predictor of survival in mastocytosis

Haematologica, 2020
A high allele burden of the KIT D816V mutation in peripheral blood or bone marrow aspirates indicates multi-lineage hematopoietic involvement and has been associated with an aggressive clinical course of systemic mastocytosis.
Georg Greiner, Michael Gurbisz, Franz Ratzinger, Nadine Witzeneder, Svenja Verena Class, Gregor Eisenwort, Ingrid Simonitsch-Klupp, Harald Esterbauer, Matthias Mayerhofer, Leonhard Müllauer, Wolfgang R. Sperr, Peter Valent, Gregor Hoermann   +12 more
doaj   +1 more source

The Impact of Common Medications on Male Fertility: An Updated Systematic Review

Andrology, EarlyView.
ABSTRACT Background Compared with those of cytotoxic treatments, the potential effects of common medications on the fertility of men trying to conceive currently or planning to conceive in the future are less well described. The use of common medications may modify the gonadotropic axis, spermatogenesis, and epididymal maturation or alter male ...
Lina Jebli, Salomé Gallissian, Roxanne Barèges, Félicia Fournier, Catherine Metzler‐Guillemain, Ségolène Prades, Fanny Magnan‐Sebag, Jeanne Perrin   +7 more
wiley   +1 more source

Systemic mastocytosis – a diagnostic challenge

Revista Brasileira de Hematologia e Hemoterapia, 2014
Mastocytosis refers to a group of disorders characterized by the infiltration of clonally derived mast cells to the skin or extracutaneous tissues resulting in a heterogeneous clinical picture. It is a rare hematologic disorder in all its forms. The exact incidence is unknown; it affects patients of any age and males and females equally.
Lladó, AC, Mihon, C, Silva, M, Galzerano, A   +3 more
openaire   +4 more sources

Colonic Mast Cell Density and Diarrhoea: Evidence Against a Threshold Effect in Biopsies From 3508 Patients

Alimentary Pharmacology &Therapeutics, EarlyView.
A large data base of colonoscopies was analysed for mast cells. The data do not show a relationship between diarrhoea and elevated mast cells in the colonic mucosa. This study provides real‐world evidence against the routine diagnostic use of colonic mast cell quantification for the evaluation of diarrhoea.
Marlena Langreiter, Robert M. Genta, Philipp Schreiner   +2 more
wiley   +1 more source

Tryptase Locus Variation Contributes to Normal‐Range Basal Serum Tryptase Variability and Is Associated With Anaphylaxis

Clinical &Experimental Allergy, EarlyView.
Tryptase locus variation explains normal‐range baseline serum tryptase differences and is associated with Hymenoptera venom anaphylaxis, independent of clonal mast cell disease and HαT. ABSTRACT Background Increased basal serum tryptase level (BST) is associated with anaphylaxis.
Manca Svetina, Jonathan J. Lyons, Peter Kopač, Julij Šelb, Mitja Košnik, Matija Rijavec, Peter Korošec   +6 more
wiley   +1 more source

Mutational status in patients with systemic mastocytosis.

, 2012
ISM, indolent systemic mastocytosis; SM-AHNMD, Systemic mastocytosis with associated clonal hematological non-mast cell lineage disease; wt, wild-type.*UPD2pterp13.1 (homozygous DNMT3A mutation).†UPD4q12qter (homozygous KIT and TET2 mutation).‡Patients ...
Valeria Visconte (143692), Paul Elson (143703), Fred H. Hsieh (143706), Matt Kalaycio (143712), Ramon V. Tiu (143732), Jaroslaw P. Maciejewski (81785), Alan E. Lichtin (143714), Hien K. Duong (143717), Yingchun Han (143704), Raghuveer Singh Mali (143710), Reuben Kapur (143722), Sara T. Olalla Saad (143727), Hideki Makishima (143698), Anjali S. Advani (143716), Mikkael A. Sekeres (143708), Anna M. Jankowska (143695), Fabiola Traina (143689), Edward Copelan (143719), Christine L. O’Keefe (143701)   +18 more
core   +1 more source

Cofactors in Anaphylaxis: Insights From the European Anaphylaxis Registry

Clinical &Experimental Allergy, EarlyView.
Forty‐nine per cent of reactions reported suspected cofactors (26% of children/adolescents, 59% of adults). Adjusted odds ratios for reaction severity increased with increasing number of suspected cofactors. Consistent effects for individual suspected cofactors were only observed for acute infections (children) and alcohol (adults with food‐induced ...
Margitta Worm, Sabine Dölle‐Bierke, Guillaume Pouessel, Franziska Ruëff, Karin Hartmann, Claudia Pföhler, Maria Beatrice Bilò, Nicola Wagner, Nikolaos G. Papadopoulos, Lars Lange, Andrea Bauer, Johannes Trück, Paul J. Turner, Veronika Höfer   +13 more
wiley   +1 more source