Results 51 to 60 of about 1,282,511 (265)

Review papers The role of KIT gene mutations in pathogenesis of pediatric mastocytosis

Przegląd Dermatologiczny, 2015
Mastocytosis is characterized by excessive proliferation and accumulation of mast cells in skin and/or other organs. Two forms of the disease, cutaneous and systemic mastocytosis, differ significantly in symptomatology and clinical course.
Joanna Dawicka, Magdalena Lange, Bartosz Wasąg, Bogusław Nedoszytko, Aleksandra Wilkowska, Roman Nowicki   +5 more
doaj   +1 more source

Can Visual Hallucinations be Among the Neuropsychological Manifestations of Systemic Mastocytosis?: A Geriatric Case

Psychiatry and Clinical Psychopharmacology, 2021
Mast cells are considered sensors of environmental and emotional stress, exist in all body parts and are related to the pathway from stress to inflammation.
Ozge Kilic, Ugur Eser Yilmaz, Zeynep Komesli, A. Cenk Ercan, Mustafa Cetiner   +4 more
doaj   +1 more source

Clinical effectiveness of hymenoptera venom immunotherapy [PDF]

, 2013
Treatment failure during venom immunotherapy (VIT) may be associated with a variety of risk factors. Our aim was to evaluate the association of baseline serum tryptase concentration (BTC) and of other parameters with the frequency of VIT failure during ...
Aberer, Werner, Biló, Maria Beatrice, Bodzenta-Lukaszyk, Anna, Bonifazi, Floriano, Campi, Paolo, Darsow, Ulf, Haeberli, Gabrielle, Hawranek, Thomas, Küchenhoff, Helmut, Lang, Roland, Müller, Ulrich, Przybilla, Bernhard, Quercia, Oliviero, Reider, Norbert, Ruëff, Franziska, Scheipl, Fabian, Schmid-Grendelmeier, Peter, Seitz, Michael J., Severino, Maurizio, Sturm, Gunter Johannes, Treudler, Regina, Wüthrich, Brunello   +21 more
core   +1 more source

Mastocytosis: a mutated KIT receptor induced myeloproliferative disorder [PDF]

, 2015
Although more than 90% systemic mastocytosis (SM) patients express gain of function mutations in the KIT receptor, recent next generation sequencing has revealed the presence of several additional genetic and epigenetic mutations in a subset of these ...
Chatterjee, Anindya, Ghosh, Joydeep, Kapur, Reuben   +2 more
core   +2 more sources

New Developments in Diagnosis, Prognostication, and Treatment of Advanced Systemic Mastocytosis.

Blood, 2020
Systemic mastocytosis (SM) has greatly benefited from the broad application of precision medicine techniques to hematolymphoid neoplasms. Sensitive detection of the recurrent KIT D816V mutation and use of next generation sequencing (NGS) panels to ...
A. Reiter, T. George, J. Gotlib
semanticscholar   +1 more source

Real-World Efficacy of Midostaurin in Aggressive Systemic Mastocytosis

Journal of Clinical Medicine, 2021
In April 2017 midostaurin was approved by the US Food and Drug Administration for the treatment of patients with aggressive systemic mastocytosis (ASM). So far, very limited real world data on its efficacy is available.
A. Szudy-Szczyrek, Oliwia Bachanek-Mitura, T. Gromek, K. Chromik, A. Mital, M. Szczyrek, W. Krupski, J. Szumiło, Z. Kanduła, G. Helbig, M. Hus   +10 more
semanticscholar   +1 more source

The KIT and PDGFRA switch-control inhibitor DCC-2618 blocks growth and survival of multiple neoplastic cell types in advanced mastocytosis

Haematologica, 2018
Systemic mastocytosis is a complex disease defined by abnormal growth and accumulation of neoplastic mast cells in various organs. Most patients exhibit a D816V-mutated variant of KIT, which confers resistance against imatinib.
Mathias Schneeweiss, Barbara Peter, Siham Bibi, Gregor Eisenwort, Dubravka Smiljkovic, Katharina Blatt, Mohamad Jawhar, Daniela Berger, Gabriele Stefanzl, Susanne Herndlhofer, Georg Greiner, Gregor Hoermann, Emir Hadzijusufovic, Karoline V. Gleixner, Peter Bettelheim, Klaus Geissler, Wolfgang R. Sperr, Andreas Reiter, Michel Arock, Peter Valent   +19 more
doaj   +1 more source

Diffuse large B cell lymphoma coexistence with systemic mastocytosis

Journal of Cancer Research and Practice, 2016
Systemic mastocytosis is a rare disease and characterized by excessive mast cell accumulation in one or multiple organs. One subtype of systemic mastocytosis is systemic mastocytosis-associated clonal hematological non-mast cell lineage disease (SM-AHMND)
Sheng-Hsuan Chien, Yao-Chung Liu, Ying-Chung Hong, Ching-Fen Yang, Chun-Yu Liu, Tzeon-Jye Chiou, Cheng-Hwai Tzeng, Jin-Hwang Liu, Jyh-Pyng Gau   +8 more
doaj   +1 more source

Mast Cell Sarcoma of the Retroperitoneum With Concurrent Systemic Mastocytosis and an Undisclosed Associated Hematologic Neoplasm: A Case Report

Clinical Pathology, 2022
Mastocytosis is a rare disorder affecting both children and adults by gathering of functionally defective mast cells in the body’s tissues. The World Health Organization (WHO) classified mastocytosis into cutaneous mastocytosis, systemic mastocytosis (SM)
Ing Chen, Jia-Bin Liao, Jung-Chia Lin, Pin-Pen Hsieh, Ming-Yun Hsieh   +4 more
doaj   +1 more source

Klinikai tapasztalataink cutan mastocytosisban. [PDF]

, 2013
Introduction: Mastocytosis is a clonal mast cell proliferative disease, devided into cutaneous and systemic forms. The characteristic symptoms are caused by neoplastic mast cell infiltrations in different organs and/or the release of mediators.
Csomor, Judit, Hidvégi, Bernadett, Hársing, Judit, Kovalszky, Ilona, Kárpáti, Sarolta, Marschalkó, Márta, Mihalik, Noémi, Várkonyi, Judit   +7 more
core   +1 more source