Results 61 to 70 of about 1,212,027 (321)

Docetaxel-Induced Systemic Sclerosis with Internal Organ Involvement Masquerading as Congestive Heart Failure

Case Reports in Immunology, 2017
Systemic sclerosis, or scleroderma, is a complex medical disorder characterized by limited or diffuse skin thickening with frequent involvement of internal organs such as lungs, gastrointestinal tract, or kidneys.
Bumsoo Park, Raghavendra C. Vemulapalli, Amit Gupta, Maria E. Shreve, Della A. Rees   +4 more
doaj   +1 more source

Capillaroscopy in 2016 : new perspectives in systemic sclerosis [PDF]

, 2016
Systemic sclerosis (SSc) is an autoimmune disorder of unknown etiology characterized by early impairment of the microvascular system. Nailfold microangiopathy and decreased peripheral blood perfusion are typical clinical aspects of SSc.
Cutolo, M, Llado, A, Paolino, S, Pizzorni, C, Ruaro, B, Smith, Vanessa, Sulli, A   +6 more
core   +1 more source

Immunochip analysis identifies multiple susceptibility loci for systemic sclerosis [PDF]

, 2014
In this study, 1,833 systemic sclerosis (SSc) cases and 3,466 controls were genotyped with the Immunochip array. Classical alleles, amino acid residues, and SNPs across the human leukocyte antigen (HLA) region were imputed and tested.
, Airó, Paolo, Alarcón-Riquelme, Marta, AlKassab, Firas, Arnett, Frank C., Assassi, Shervin, Baron, Murray, Beretta, Lorenzo, Bossini-Castillo, Lara, Broen, Jasper, Brown, Matthew, Carmona, Francisco David, Carreira, Patricia, Castellví, Iván, Chen, Wei V., Denton, Christopher, Distler, Jörg H.W., Docherty, Peter, Fessler, Barri J., Fonseca, Carmen, Frech, Tracy M., Furst, Daniel E., González-Gay, Miguel Ángel, Gorlova, Olga, Gregersen, Peter K., Guerra, Sandra, Herrick, Ariane, Hesselstrand, Roger, Hinchcliff, Monique E., Hudson, Marie, Hummers, Laura K., Hunzelmann, Nicolas, Jones, Henry Niall, Kaminska, Elzbieta, Khalidi, Nader, Khanna, Dinesh, Koeleman, Bobby P., Kreuter, Alexander, Lafyatis, Robert A., Lee, Annette T., Lunardi, Claudio, López-Isac, Elena, Markland, Janet, Martin, Javier, Martin, José Ezequiel, Mayes, Maureen D., Molitor, Jerry A., Nordin, Annika, Ochoa, Eguzkine, Padyukov, Leonid, Phillips, Kristin, Pope, Janet E., Radstake, Timothy R.D.J., Reveille, John D., Riemekasten, Gabriela, Robinson, David, Schiopu, Elena, Schuerwegh, Annemie J., Segal, Barbara M., Shiels, Paul, Silver, Richard M., Simeón, Carmen Pilar, Simms, Robert W., Steen, Virginia D., Tan, Filemon K., Teruel, María, van Laar, Jacob M., Varga, John, Voskuyl, Alexandre E., Wigley, Fredrick M., Wijmenga, Cisca, Witte, Torsten, Worthington, Jane, Ying, Jun, Zhernakova, Alexandra, Zhou, Xiaodong   +75 more
core   +1 more source

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source

Hand Swelling and Other Non–Raynaud Phenomenon Symptoms as the Initial Presentation of Systemic Sclerosis: Prevalence and Clinical Associations in Two US Cohorts

Arthritis &Rheumatology, EarlyView.
Objective Raynaud phenomenon (RP) is often the initial clinical manifestation of systemic sclerosis (SSc), but some patients develop other manifestations first. To help elucidate the diversity of SSc presentation in its early stages, we describe the initial clinical manifestations and antinuclear antibody (ANA) profiles of patients in two early SSc ...
Iqtidar Hanif, Shervin Assassi, Maureen D. Mayes, Zsuzsanna H. McMahan, Meng Zhang, Julio Charles, John M. VanBuren, Jessica S. Alvey, Kimia Ghaffari, Elana J. Bernstein, Flavia V. Castelino, Lorinda Chung, Luke Evnin, Tracy M. Frech, Jessica K. Gordon, Faye N. Hant, Laura K. Hummers, Dinesh Khanna, Kimberly S. Lakin, Dorota Lebiedz‐Odrobina, Yiming Luo, Ashima Makol, Jerry A. Molitor, Duncan F. Moore, Carrie Richardson, Nora Sandorfi, Ami A. Shah, Ankoor Shah, Victoria K. Shanmugam, Virginia D. Steen, Elizabeth R. Volkmann, Carleigh Zahn, Brian Skaug   +32 more
wiley   +1 more source

Fat Grafting Subjectively Improves Facial Skin Elasticity and Hand Function of Scleroderma Patients

Plastic and Reconstructive Surgery, Global Open, 2021
Summary:. Systemic scleroderma is a chronic connective tissue disease characterized by internal organ and skin fibrosis. Unfortunately, there is a lack of efficacious treatments for cutaneous manifestations, and alternative interventions should be ...
Amy L. Strong, MD, PhD, Widya Adidharma, MD, Owen H. Brown, MD, Paul S. Cederna, MD   +3 more
doaj   +1 more source

Prognostic Factors of Renal Involvement in Systemic Sclerosis [PDF]

, 2018
Background/Aims: Renal involvement is common in systemic sclerosis (SSc), including asymptomatic reduction of glomerular filtration rate (GFR), increased renal resistance indices, scleroderma renal crisis (SRC) and ANCA-associated vasculitis. The aim was
Barbano, Biagio, Cianci, Rosario, Gasperini, Maria Ludovica, Gigante, Antonietta, Muscaritoli, Maurizio, Rosato, Edoardo   +5 more
core   +2 more sources

Mucosal‐Associated Invariant T Cells in Rheumatic Diseases

Arthritis &Rheumatology, EarlyView.
Mucosal‐associated invariant T (MAIT) cells are innate‐like T cells defined by their semi‐invariant T cell receptor and restriction by the major histocompatibility complex class I–related molecule (MR1). These cells are primarily activated by microbial‐derived metabolites presented by MR1 or by cytokines.
Manon Lesturgie‐Talarek, Virginie Gonzalez, Lucie Beaudoin, Noémie Sénot, Corinne Miceli‐Richard, Yannick Allanore, Agnès Lehuen, Jerôme Avouac   +7 more
wiley   +1 more source

Immunologic and nonimmunologic sclerodermal skin conditions - review

Frontiers in Immunology, 2023
Scleroderma-like cutaneous lesions have been found in many pathological conditions and they have the clinical appearance of sclerotic or scleroatrophic lesions.
Carmen Bobeica, Elena Niculet, Elena Niculet, Mihaela Craescu, Mihaela Craescu, Elena-Laura Parapiru, Andreea Mioara Corduneanu-Luca, Mihaela Debita, Ana Maria Pelin, Carmen Tiutiuca, Claudiu Ionut Vasile, Alin Codrut Nicolescu, Magdalena Miulescu, Gabriela Balan, Gabriela Balan, Alin Laurentiu Tatu, Alin Laurentiu Tatu, Alin Laurentiu Tatu   +17 more
doaj   +1 more source

Elevated expression of type VII collagen in the skin of patients with systemic sclerosis. Regulation by transforming growth factor-beta. [PDF]

, 1994
A hallmark of systemic sclerosis (SSc) is the development of tissue fibrosis. Excessive production of several connective tissue components normally present in the dermis, including type I, III, V, and VI collagens as well as fibronectin and proteoglycans,
Christiano, Angela M., Iozzo, Renato V., Jimenez, Sergio A., Rudnicka, Lidia, Uitto, Jouni, Varga, John   +5 more
core   +3 more sources