Results 281 to 290 of about 311,988 (356)
Dysregulation of U12‐Type Splicing in Lupus Neutrophils
Arthritis &Rheumatology, Accepted Article.Abstract. Objective
Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...Luz P. Blanco, Binod Regmi, Carmelo Carmona‐Rivera, Yudong Liu, Xiantao Wang, Philip M. Carlucci, Monica M. Jackson, Zerai Manna, Sarfaraz Hasni, Markus Hafner, Hong‐Wei Sun, Mariana J. Kaplan +11 morewiley +1 more sourceBlood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data
British Journal of Clinical Pharmacology, EarlyView.SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes.
These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić +7 morewiley +1 more sourcePreventive effects of early immunosuppressive treatment on the development of interstitial lung disease in systemic sclerosis. [PDF]
Rheumatology (Oxford)Velauthapillai A, Bootsma MFR, Bruni C, Bergmann C, Matucci-Cerinic M, Launay D, Riemekasten G, Garzanova L, Airò P, Rezus E, da Silva JAP, Del Galdo F, Hunzelmann N, Chung LS, Krasowska D, Distler O, van den Ende CHM, Vonk MC, EUSTAR Collaborators
. +18 moreeuropepmc +1 more sourcePOS0947 ANTI-NOR-90 ANTIBODIES IN AN INTERNATIONAL COHORT OF 2140 SYSTEMIC SCLEROSIS SUBJECTS: CLINICAL ASSOCIATIONS
Hui Shen, Marie Hudson, Susanna Proudman, Jenny Walker, W. Stevens, Mandana Nikpour, Shervin Assassi, Maureen D. Mayes, M. Wang, Valérie Leclair, Yves Troyanov, Murray Baron, Maggie Larché, May Y. Choi, Mohammed Osman, Janet Pope, C. Thorne, M J Fritzler, S. Hoa +18 moreopenalex +1 more sourcePopulation pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia
British Journal of Clinical Pharmacology, EarlyView.Background
Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.Andrew M. Brandon, Hinke Huisman‐Siebinga, Shelby Barnett, Paul Wetherell, Pamela Kearns, Brenda Gibson, Nicholas Heaney, Owen Smith, André Baruchel, Arnaud Petit, Andrew Moore, Kayode Ogungbenro, Alwin D. R. Huitema, Gareth J. Veal +13 morewiley +1 more sourcePOS1128 Age of onset effect on the clinical manifestations of patients with Juvenile Systemic Sclerosis
Ivan Foeldvari, J. Klotsche, K. Torok, O. Kasapcopur, A. Adrovic, B. Feldman, Flávio Sztajnbok, Maria Teresa Terreri, Ana Paula Sakamoto, R. Khubchandani, Jordi Antón, Gülcan Özomay Baykal, Stephanie Johnson, D. Schonenberg, V. Stanevicha, Е.I. Alexeeva, M. Katsikas, Sujata Sawhney, V. Smith, S. Abu Al Saoud, Eslam Al‐Abadi, S. Appenzeller, T. Avcin, Natasha Cabrera, S Hájek, Mikhail M. Kostik, T. Lehman, S. Li, Hana Malcová, E. Marrani, S. Opsahl Hetlevik, C. Pain, A. Patwardhan, Walter Alberto Sifuentes Giraldo, N. Vasquez-Canizares, Patrícia Costa‐Reis, M. Janarthanan, M. Moll, Dana Němcová, M.J. Santos, C. Battagliotti, L. Berntson, B. Bica, J. Brunner, D. Eleftheriou, L. Harel, G. Horneff, Daniela Kaiser, T. Kallinich, Dragana Lazarević, J.M. López Benítez, K. Minden, Søren Nielsen, Farzana Nuruzzaman, Mihaela Spârchez, Y. Uziel, N. Helmus +56 moreopenalex +1 more source