Results 281 to 290 of about 311,988 (356)

Dysregulation of U12‐Type Splicing in Lupus Neutrophils

open access: yesArthritis &Rheumatology, Accepted Article.
Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco   +11 more
wiley   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić   +7 more
wiley   +1 more source

Preventive effects of early immunosuppressive treatment on the development of interstitial lung disease in systemic sclerosis. [PDF]

open access: yesRheumatology (Oxford)
Velauthapillai A   +18 more
europepmc   +1 more source

POS0947 ANTI-NOR-90 ANTIBODIES IN AN INTERNATIONAL COHORT OF 2140 SYSTEMIC SCLEROSIS SUBJECTS: CLINICAL ASSOCIATIONS

open access: hybrid
Hui Shen   +18 more
openalex   +1 more source

Population pharmacokinetics and dose–response relationships of mitoxantrone in children with acute myeloid leukaemia

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Background Information on mitoxantrone pharmacokinetics in children is lacking and reduced dosing regimens applied to infants are supported by limited scientific rationale. The current study characterized mitoxantrone pharmacokinetics in a childhood acute myeloid leukaemia patient population and provides a data‐informed assessment of dosing.
Andrew M. Brandon   +13 more
wiley   +1 more source

POS1128 Age of onset effect on the clinical manifestations of patients with Juvenile Systemic Sclerosis

open access: hybrid
Ivan Foeldvari   +56 more
openalex   +1 more source

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