α2-Antiplasmin as a Potential Therapeutic Target for Systemic Sclerosis
Life, 2022 Systemic sclerosis is a connective tissue disease of unknown origin that is characterized by immune system abnormalities, vascular damage, and extensive fibrosis of the skin and visceral organs.
Yosuke Kanno, En Shu
doaj +1 more source
Effectiveness of regional diffusion MRI measures in distinguishing multiple sclerosis abnormalities within the cervical spinal cord [PDF]
, 2021 Multiple sclerosis is an inflammatory disorder of the central nervous system. Quantitative MRI has huge potential to provide intrinsic and normative values of tissue properties useful for diagnosis, prognosis and ultimately clinical follow-up of this disease.
arxiv +1 more source
Predictors of progression in systemic sclerosis patients with interstitial lung disease
European Respiratory Journal, 2020 Systemic sclerosis (SSc) is a systemic autoimmune disease affecting multiple organ systems, including the lungs. Interstitial lung disease (ILD) is the leading cause of death in SSc.
O. Distler +12 more
semanticscholar +1 more source
Connective tissue disease-associated pulmonary arterial hypertension. [PDF]
, 2015 Although rare in its idiopathic form, pulmonary arterial hypertension (PAH) is not uncommon in association with various associated medical conditions, most notably connective tissue disease (CTD).
Condliffe, R., Howard, L.S.
core +2 more sources
Reaction-diffusion systems derived from kinetic theory for Multiple Sclerosis [PDF]
, 2023 We present a mathematical study for the development of Multiple Sclerosis in which a spatio-temporal kinetic { theory} model describes, at the mesoscopic level, the dynamics of a high number of interacting agents. We consider both interactions among different populations of human cells and the motion of immune cells, stimulated by cytokines.
arxiv +1 more source
Arthritis & Rheumatology, 2020 To describe the associations between autoantibodies, clinical presentation, and outcomes among patients with systemic sclerosis (SSc) in order to develop a novel SSc classification scheme that would incorporate both antibodies and the cutaneous disease ...
S. Nihtyanova +7 more
semanticscholar +1 more source
QTc interval prolongation in systemic sclerosis [PDF]
, 2017 QTc interval prolongation in systemic ...
Gigante, Antonietta +2 more
core +1 more source
Nintedanib for Systemic Sclerosis-Associated Interstitial Lung Disease.
New England Journal of Medicine, 2019 BACKGROUND Interstitial lung disease (ILD) is a common manifestation of systemic sclerosis and a leading cause of systemic sclerosis-related death. Nintedanib, a tyrosine kinase inhibitor, has been shown to have antifibrotic and antiinflammatory effects ...
O. Distler +14 more
semanticscholar +1 more source
Smoking in Systemic Sclerosis: a Longitudinal European Scleroderma Trials and Research Group Study [PDF]
, 2018 Data on the role of tobacco exposure in systemic sclerosis (SSc) severity and progression are scarce. We aimed to assess the effects of smoking on the evolution of pulmonary and skin manifestations in the EUSTAR ...
Airó, Paolo +25 more
core +5 more sources
Evaluation of the primary biliary cholangitis-related serologic profile in a large cohort of Belgian systemic sclerosis patients [PDF]
, 2020 Background: Systemic sclerosis (SSc) and primary biliary cholangitis (PBC) are autoimmune diseases that may occur concomitantly and are both strongly associated with disease-specific autoantibodies.
Bonroy, Carolien +6 more
core +1 more source