Results 41 to 50 of about 2,931,663 (352)

The systemic lupus erythematosus IRF5 risk haplotype is associated with systemic sclerosis [PDF]

open access: yes, 2013
Systemic sclerosis (SSc) is a fibrotic autoimmune disease in which the genetic component plays an important role. One of the strongest SSc association signals outside the human leukocyte antigen (HLA) region corresponds to interferon (IFN) regulatory ...
Schuerwegh, A. J.   +219 more
core   +2 more sources

Systemic sclerosis

open access: yesThe Journal of Dermatology, 2017
AbstractSystemic sclerosis (SSc) is a multisystem autoimmune disease characterized by vasculopathy and tissue fibrosis of the skin and various internal organs. A series of genetic and epidemiological studies have demonstrated that SSc onset is determined by the accumulation of predisposing factors related to environmental influences, while genetic ...
Denton, CP, Khanna, D
openaire   +5 more sources

Genome-Wide Scan Identifies TNIP1, PSORS1C1, and RHOB As Novel Risk Loci for Systemic Sclerosis [PDF]

open access: yes, 2011
Systemic sclerosis (SSc) is an orphan, complex, inflammatory disease affecting the immune system and connective tissue. SSc stands out as a severely incapacitating and life-threatening inflammatory rheumatic disease, with a largely unknown pathogenesis ...
P. Amouyel   +245 more
core   +2 more sources

Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy [PDF]

open access: yes, 2011
The aim of this study was to determine, through a genome-wide association study (GWAS), the genetic components contributing to different clinical sub-phenotypes of systemic sclerosis (SSc).
Kreuter, A   +620 more
core   +4 more sources

Systemic Sclerosis and Cancer [PDF]

open access: yesInternational Journal of Immunopathology and Pharmacology, 2009
To review recent advances and current controversies on the association between systemic sclerosis (SSc) and cancer, PUBMED was searched from 1966 to the present using the terms: systemic sclerosis, cancer, morphoea, sclerotic diseases. Malignancies, mainly in lung and breast, coexist with idiopathic SSc or with SSc-like disorders, but not with ...
Laura Belloli   +3 more
openaire   +4 more sources

α2-Antiplasmin as a Potential Therapeutic Target for Systemic Sclerosis

open access: yesLife, 2022
Systemic sclerosis is a connective tissue disease of unknown origin that is characterized by immune system abnormalities, vascular damage, and extensive fibrosis of the skin and visceral organs.
Yosuke Kanno, En Shu
doaj   +1 more source

Tocilizumab in systemic sclerosis: a randomised, double-blind, placebo-controlled, phase 3 trial.

open access: yesThe Lancet Respiratory Medicine, 2020
BACKGROUND A phase 2 trial of tocilizumab showed preliminary evidence of efficacy in systemic sclerosis. We assessed skin fibrosis and systemic sclerosis-associated interstitial lung disease (SSc-ILD) in a phase 3 trial to investigate the safety and ...
D. Khanna   +92 more
semanticscholar   +1 more source

Incidence and prevalence of systemic sclerosis globally: a comprehensive systematic review and meta-analysis

open access: yesRheumatology, 2021
Objectives We aimed to conduct a systematic review and meta-analysis on the incidence and prevalence of SSc covering the entire literature. Methods This study followed the recommendations of the Preferred Reporting Items for Systematic Reviews and Meta ...
M. Bairkdar   +5 more
semanticscholar   +1 more source

Erectile dysfunction is frequent in systemic sclerosis and associated with severe disease: a study of the EULAR Scleroderma Trial and Research group [PDF]

open access: yes, 2012
INTRODUCTION: Erectile dysfunction (ED) is common in men with systemic sclerosis (SSc) but the demographics, risk factors and treatment coverage for ED are not well known.
Smith, Vanessa   +62 more
core   +1 more source

Pathogenesis of Systemic Sclerosis [PDF]

open access: yesFrontiers in Immunology, 2015
Systemic scleroderma (SSc) is one of the most complex systemic autoimmune diseases. It targets the vasculature, connective tissue-producing cells (namely fibroblasts/myofibroblasts), and components of the innate and adaptive immune systems. Clinical and pathologic manifestations of SSc are the result of: (1) innate/adaptive immune system abnormalities ...
Debendra ePattanaik   +5 more
openaire   +3 more sources

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