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Pathogenesis of systemic sclerosis associated interstitial lung disease
Journal of Scleroderma and Related Disorders, 2020 Systemic sclerosis is an autoimmune disease leading to vasculopathy and fibrosis of skin and internal organs. Despite likely shared pathogenic mechanisms, the patterns of skin and lung fibrosis differ.
S. Nihtyanova, C. Denton
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Oxidative stress in the pathogenesis of systemic scleroderma: An overview [PDF]
, 2018 Systemic sclerosis (SSc) is a rare disorder of the connective tissue characterized by fibrosis of the skin, skeletal muscles and visceral organs. Additional manifestations include activation of the immune system and vascular injury. SSc causes disability
Gambardella, Lucrezia +5 more
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SYSTEMIC SCLEROSIS AND OSTEOPOROSIS
Alʹmanah Kliničeskoj Mediciny, 2016 Systemic sclerosis is an autoimmune inflammatory disease of connective tissue with multi-syndrome clinical manifestations. Skeletal damage is considered to be one of significant contributors to the quality of life of these patients.
R. T. Alekperov, N. V. Toroptsova
doaj +1 more source
Lung ultrasound in systemic sclerosis: correlation with high-resolution computed tomography, pulmonary function tests and clinical variables of disease [PDF]
, 2015 Interstitial lung disease (ILD) is a hallmark of systemic sclerosis (SSc). Although high-resolution computed tomography (HRCT) is the gold standard to diagnose ILD, recently lung ultrasound (LUS) has emerged in SSc patients as a new promising technique ...
Amoroso, Antonio +8 more
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Definition of Naturally Processed Peptides Reveals Convergent Presentation of Autoantigenic Topoisomerase I Epitopes in Scleroderma. [PDF]
, 2020 ObjectiveAutoimmune responses to DNA topoisomerase I (topo I) are found in a subset of scleroderma patients who are at high risk for interstitial lung disease (ILD) and mortality.
Boin, Francesco +9 more
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Przegląd Dermatologiczny, 2017 Systemic sclerosis is an immune-mediated disease characterized by a chronic and progressive course. It often leads to multiorgan failure and patient disability, and contributes to significant reduction in the quality of life.
Dorota Krasowska +10 more
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Serum uric acid as a marker of microvascular damage in systemic sclerosis patients [PDF]
, 2016 Background: Microvascular damage of skin and internal organs is a hallmark of systemic sclerosis (SSc). Serum uric acid (UA) represents a marker of inflammation and endothelial dysfunction.
Amoroso, Antonio +9 more
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Pulmonary vasospasm in systemic sclerosis: noninvasive techniques for detection [PDF]
, 2014 In a subgroup of patients with systemic sclerosis (SSc), vasospasm affecting the pulmonary circulation may contribute to worsening respiratory symptoms, including dyspnea.
Giannarou, S +8 more
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Discontinuation of Immunotherapy in Patients With Relapsing Myelitis Without AQP4/MOG Antibodies
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT This study assesses the outcomes of immunotherapy discontinuation in patients with relapsing seronegative idiopathic myelitis (SIM), a condition that remains uninvestigated due to its rarity. We reviewed records from 77 patients with relapsing SIM at the National Cancer Center of Korea, focusing on 11 who discontinued treatment after a median ...
Ki Hoon Kim +4 more
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Journal of Scleroderma and Related Disorders, 2020 The natural history of interstitial lung disease in patients with systemic sclerosis is highly variable. Historical observational studies have demonstrated that the greatest decline in lung function in systemic sclerosis occurs early in the course of the
E. Volkmann
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