Insights Into the Antigenic Repertoire of Unclassified Synaptic Antibodies
ABSTRACT Objective We sought to characterize the sixth most common finding in our neuroimmunological laboratory practice (tissue assay‐observed unclassified neural antibodies [UNAs]), combining protein microarray and phage immunoprecipitation sequencing (PhIP‐Seq). Methods Patient specimens (258; 133 serums; 125 CSF) meeting UNA criteria were profiled;
Michael Gilligan +22 more
wiley +1 more source
Epidemiology of systemic sclerosis and systemic sclerosis-associated interstitial lung disease
Aurore Bergamasco,1 Nadine Hartmann,2 Laura Wallace,3 Patrice Verpillat41YolaRx Consultants, Paris, France; 2Boehringer Ingelheim International GmbH, Ingelheim am Rhein, Germany; 3Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, CO, USA ...
Bergamasco A +3 more
doaj
Genetics of scleroderma: implications for personalized medicine?
Significant advances have been made in understanding the genetic basis of systemic sclerosis (scleroderma) in recent years. Can these discoveries lead to individualized monitoring and treatment?
Assassi Shervin +3 more
doaj +1 more source
Emerging patterns of genetic overlap across autoimmune disorders. [PDF]
Most of the recently identified autoimmunity loci are shared among multiple autoimmune diseases. The pattern of genetic association with autoimmune phenotypes varies, suggesting that certain subgroups of autoimmune diseases are likely to share ...
Criswell, Lindsey A +1 more
core +1 more source
Cumulative disease damage and anti-PM/Scl antibodies are associated with a heavy burden of calcinosis in systemic sclerosis [PDF]
Carrie Richardson +7 more
openalex +1 more source
Post‐COVID Fatigue Is Associated With Reduced Cortical Thickness After Hospitalization
ABSTRACT Objective Neuropsychiatric symptoms are among the most prevalent sequelae of COVID‐19, particularly among hospitalized patients. Recent research has identified volumetric brain changes associated with COVID‐19. However, it currently remains poorly understood how brain changes relate to post‐COVID fatigue and cognitive deficits.
Tim J. Hartung +190 more
wiley +1 more source
Systemic sclerosis, or scleroderma, is a complex medical disorder characterized by limited or diffuse skin thickening with frequent involvement of internal organs such as lungs, gastrointestinal tract, or kidneys.
Bumsoo Park +4 more
doaj +1 more source
Angiogenic and angiostatic factors in renal scleroderma-associated vasculopathy [PDF]
BACKGROUND: The angiogenesis in systemic sclerosis (SSc) is impaired. An imbalance of pro-angiogenic factors and angiogenesis inhibitors has been implicated in the progression of peripheral microvascular damage, defective vascular repair and fibrosis ...
Afeltra, Antonella M. Vittoria +7 more
core +1 more source
Evaluation of left cardiac chamber function with cardiac magnetic resonance and association with outcome in patients with systemic sclerosis [PDF]
Steele C. Butcher +13 more
openalex +1 more source
Immunogenetics of Systemic Sclerosis
Systemic sclerosis (SSc) is a rare autoimmune connective tissue disorder characterized by massive fibrosis, vascular damage, and immune imbalance. Advances in rheumatology and immunology over the past two decades have led to a redefinition of systemic sclerosis, shifting from its initial perception as primarily a “hyperfibrotic” state towards a ...
Olga Gumkowska-Sroka +2 more
openaire +3 more sources

