Results 151 to 160 of about 1,150,837 (304)

Molecular imaging predicts trastuzumab‐deruxtecan (T‐DXd) response in head and neck cancer xenograft models

Molecular Oncology, EarlyView.
Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed, Lucas Mani, Muhammad Bilal Mirza, Ashtyn McAdoo, Takahito Kondo, Hidenori Tanaka, Nicole Meeks, Eben Rosenthal, Marisa Hom   +8 more
wiley   +1 more source

Roadmap for a Systems Biology Initiative in Iran. [PDF]

J Med Signals Sens
Kamali Z, Jalilvandnejad A, Falenji B, Zarei P, Lotfi M, Hadizadeh F, Vaez A.   +6 more
europepmc   +1 more source

Cavefish as a Model System in Evolutionary Developmental Biology

, 2001
William R. Jeffery
openalex   +1 more source

From functional genomics to systems biology: concepts and practices [PDF]

, 2003
Charles Auffray, Sandrine Imbeaud, Magali Roux-Rouquié, Leroy Hood   +3 more
openalex   +1 more source

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

11th Intelligent Systems for Molecular Biology 2003 (ISMB 2003) [PDF]

, 2003
Catherine A. Abbott
openalex   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Unravelling the Complexity of Sarcopenia Through a Systems Biology Approach. [PDF]

Int J Mol Sci
Ceyhan AB, Altay O, Zhang C, Temel SG, Turkez H, Mardinoglu A.   +5 more
europepmc   +1 more source

Telomere Lengths and Telomerase Activity in Dog Tissues: A Potential Model System to Study Human Telomere and Telomerase Biology

, 2001
Lubna Nasir, Pauline Devlin, Tom P. McKevitt, Gerard R. Rutteman, David J. Argyle   +4 more
openalex   +1 more source

Frontiers of Plant Cell Biology: Signals and Pathways, System-Based Approaches 22nd Symposium in Plant Biology (University of California—Riverside) [PDF]

, 2003
Peter V. Minorsky
openalex   +1 more source