Results 11 to 20 of about 25,508,313 (370)
PEtab—Interoperable specification of parameter estimation problems in systems biology [PDF]
PLoS Comput. Biol., 2020 Reproducibility and reusability of the results of data-based modeling studies are essential. Yet, there has been—so far—no broadly supported format for the specification of parameter estimation problems in systems biology.
Leonard Schmiester +57 more
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Systems biology at the Institute for Systems Biology [PDF]
Briefings in Functional Genomics and Proteomics, 2008 Systems biology represents an experimental approach to biology that attempts to study biological systems in a holistic rather than an atomistic manner. Ideally this involves gathering dynamic and global data sets as well as phenotypic data from different levels of the biological information hierarchy, integrating them and modeling them graphically and ...
David J. Galas +3 more
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Systems biology reveals biology of systems [PDF]
Complexity, 2010 AbstractIn the last decades, genomic and postgenomic technologies obtained a great amount of information on molecular bases of cell physiology and organization. In spite of this, the knowledge of cells and living organisms in their entirety, is far from being achieved.
Alessandro Giuliani +2 more
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Resonance, 2010 Systems biology seeks to study biological systems as a whole, contrary to the reductionist approach that has dominated biology. Such a view of biological systems emanating from strong foundations of molecular level understanding of the individual components in terms of their form, function and interactions is promising to transform the level at which ...
Raman, Karthik, Chandra, Nagasuma
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Systems biology versus molecular biology [PDF]
Current Biology, 2004 Molecular biology and systems biology provide answers to the same questions, but the answers are quite different for the two approaches and are, on the surface, unrelated. The molecular biological answers are arguably more fundamental and are unique, but alternative systems biology answers are possible – consider the two systems-level answers to the ...
Charles F. Stevens
openalex +5 more sources
Metabolomic systems biology of trypanosomes [PDF]
, 2010 Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental ...
BARBARA M. BAKKER +4 more
core +7 more sources
Reproducibility in systems biology modelling
bioRxiv, 2020 The reproducibility crisis has emerged as an important concern across many fields of science including life science, since many published results failed to reproduce.
Krishna Tiwari +13 more
semanticscholar +1 more source
A multidimensional systems biology analysis of cellular senescence in aging and disease
Genome Biology, 2020 Cellular senescence, a permanent state of replicative arrest in otherwise proliferating cells, is a hallmark of aging and has been linked to aging-related diseases.
R. Avelar +15 more
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Systems biology in animal sciences [PDF]
, 2011 Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Bannink, A. +4 more
core +3 more sources
Systems-biology dissection of eukaryotic cell growth
BMC Biology, 2010 A recent article in BMC Biology illustrates the use of a systems-biology approach to integrate data across the transcriptome, proteome and metabolome of budding yeast in order to dissect the relationship between nutrient conditions and cell growth.See ...
T. Przytycka, Justen Andrews
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