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Frontiers in Plant Science, 2014 The understanding of biological complexity has been greatly facilitated by cross-disciplinary, holistic approaches that allow insights into the function and regulation of biological processes that cannot be captured by dissecting them into their individual components. In addition, the development of novel tools has dramatically increased our ability to
Wolfgang eSchmidt
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Frontiers in Genetics, 2015 The marine environment accounts for an important part of the earth biodiversity, featuring several types of (even extreme) ecosystems, and is at the origin of life. Marine prokaryotic and eukaryotic organisms are very diverse, and are sometimes, in particular for the latter, the result of intricate evolutionary history. This biodiversity, encounters in
Thierry eTonon, Damien eEveillard
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Advancing Cancer Systems Biology: Introducing the Center for the Development of a Virtual Tumor, CViT [PDF]
Cancer Informatics, 2007 Integrative cancer biology research relies on a variety of data-driven computational modeling and simulation methods and techniques geared towards gaining new insights into the complexity of biological processes that are of critical importance for cancer
Sean Martin +2 more
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Systems engineering to systems biology
Molecular Systems Biology, 2008 Mol Syst Biol. 4: 185 The ‘bottom‐up’ approach to systems biology entails quantitatively studying complex biological processes by analyzing their molecular components. A converse system biology approach is to infer properties of biological systems in a ‘top‐down’ fashion, using a variety of network reverse engineering methods, data‐driven modeling and
Muhammed A Yıldırım, Marc Vidal
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Systems immunology: When systems biology meets immunology [PDF]
Frontiers in ImmunologyThe immune system is an intricate network of cells, proteins, and signaling pathways that coordinate protective responses and, when dysregulated, drive immune−related diseases.
Lucía Alfonso-González +3 more
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Computational Systems Biology [PDF]
The Scientific World Journal, 2013 Xing-Ming Zhao +3 more
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Systems biology at the Institute for Systems Biology [PDF]
Briefings in Functional Genomics and Proteomics, 2008 Systems biology represents an experimental approach to biology that attempts to study biological systems in a holistic rather than an atomistic manner. Ideally this involves gathering dynamic and global data sets as well as phenotypic data from different levels of the biological information hierarchy, integrating them and modeling them graphically and ...
Leroy, Hood +3 more
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Pioneer factors in development and cancer
iScience, 2021 Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
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