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Systems biology at the Institute for Systems Biology [PDF]

open access: yesBriefings in Functional Genomics and Proteomics, 2008
Systems biology represents an experimental approach to biology that attempts to study biological systems in a holistic rather than an atomistic manner. Ideally this involves gathering dynamic and global data sets as well as phenotypic data from different levels of the biological information hierarchy, integrating them and modeling them graphically and ...
David J. Galas   +3 more
openaire   +3 more sources

Systems biology reveals biology of systems [PDF]

open access: yesComplexity, 2010
AbstractIn the last decades, genomic and postgenomic technologies obtained a great amount of information on molecular bases of cell physiology and organization. In spite of this, the knowledge of cells and living organisms in their entirety, is far from being achieved.
Alessandro Giuliani   +2 more
openaire   +3 more sources

Systems biology in animal sciences [PDF]

open access: yes, 2011
Systems biology is a rapidly expanding field of research and is applied in a number of biological disciplines. In animal sciences, omics approaches are increasingly used, yielding vast amounts of data, but systems biology approaches to extract ...
Bannink, A.   +4 more
core   +2 more sources

Metabolomic systems biology of trypanosomes [PDF]

open access: yes, 2010
Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental ...
BARBARA M. BAKKER   +4 more
core   +5 more sources

Formal Systems Architectures for Biology [PDF]

open access: yes, 2011
When the word "systems" is used in systems biology, it invokes a variety of assumptions about what defines the subject under investigation, which in turn can lead to divergent research outcomes.
Bradly Alicea
core   +2 more sources

Computational inference in systems biology [PDF]

open access: yes, 2015
Parameter inference in mathematical models of biological pathways, expressed as coupled ordinary differential equations (ODEs), is a challenging problem. The computational costs associated with repeatedly solving the ODEs are often high.
A. Lotka   +9 more
core   +1 more source

Integrative biology and systems biology [PDF]

open access: yesMolecular Systems Biology, 2005
Mol Syst Biol. 1: 2005.0004 Demarcations of scientific fields have always followed either a conceptual breakthrough or have been a result of profoundly enabling technologies. Quantum theory and quantum mechanics revolutionized physics and engineering, but high‐energy physics is a discipline fundamentally enabled by the linear accelerator.
openaire   +3 more sources

Inferential stability in systems biology [PDF]

open access: yes, 2011
The modern biological sciences are fraught with statistical difficulties. Biomolecular stochasticity, experimental noise, and the “large p, small n” problem all contribute to the challenge of data analysis.
Kirk, Paul, Kirk, Paul
core   +1 more source

Systems Biology: An Approach

open access: yesClinical Pharmacology & Therapeutics, 2010
In just over a decade, Systems Biology has moved from being an idea, or rather a disparate set of ideas, to a mainstream feature of research and funding priorities. Institutes, departments, and centers of various flavors of Systems Biology have sprung up all over the world. An Internet search now produces more than 2 million hits.
Kohl P.   +3 more
openaire   +5 more sources

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