Results 11 to 20 of about 2,989,026 (346)
iScience, 2021 Summary: We aimed to identify triple-negative breast cancer (TNBC) drivers that regulate survival time as predictive signatures that improve TNBC prognostication.
Courtney D. Dill +4 more
doaj +1 more source
iScience, 2022 Summary: Autoimmune diseases (ADs) are at a significantly higher risk of cancers with unclear mechanism. By searching GWAS catalog database and Medline, susceptible genes for five common ADs, including systemic lupus erythematosus (SLE), rheumatoid ...
Shasha Li +10 more
doaj +1 more source
A metabolic regulatory network for the Caenorhabditis elegans intestine
iScience, 2022 Summary: Metabolic perturbations can affect gene expression, for instance to rewire metabolism. While numerous efforts have measured gene expression in response to individual metabolic perturbations, methods that determine all metabolic perturbations ...
Sushila Bhattacharya +7 more
doaj +1 more source
iScience, 2021 Summary: Whether arterial-venous differences of primary endothelial cells commonly used for vascular research are preserved in vitro remains under debate.
Fabian Vega-Tapia +2 more
doaj +1 more source
iScience, 2021 Summary: Base editing (BE) is a promising genome engineering tool for modifying DNA or RNA and has been widely used in various microorganisms as well as eukaryotic cells.
Tianyuan Su +6 more
doaj +1 more source
A yeast chemogenomic screen identifies pathways that modulate adipic acid toxicity
iScience, 2021 Summary: Adipic acid production by yeast fermentation is gaining attention as a renewable source of platform chemicals for making nylon products. However, adipic acid toxicity inhibits yeast growth and fermentation.
Eugene Fletcher +3 more
doaj +1 more source
STAR Protocols, 2023 Summary: RNA-binding proteins (RBPs) can bind and mediate RNA-RNA contacts. However, identifying specific RBP-organized RNA-RNA contacts remains challenging.
Rong Ye, Naijing Hu, Yuanchao Xue
doaj +1 more source
Planetary Systems Biology [PDF]
Molecular Cell, 2005 Combining paleogenetics, protein engineering, synthetic biology, and metabolic modeling, a planetary biology perspective is brought to bear on adaptive evolutionary events in ancient bacteria.
Department of Chemistry, University of Florida, Gainesville, FL 32611 USA ( host institution ) +2 more
openaire +3 more sources
Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning
iScience, 2021 Summary: Clear cell renal cell carcinoma (ccRCC) is the most common histological type of kidney cancer and has high heterogeneity. Stratification of ccRCC is important since distinct subtypes differ in prognosis and treatment.
Xiangyu Li +12 more
doaj +1 more source
Computational inference in systems biology [PDF]
, 2015 Parameter inference in mathematical models of biological pathways, expressed as coupled ordinary differential equations (ODEs), is a challenging problem. The computational costs associated with repeatedly solving the ODEs are often high.
A. Lotka +9 more
core +1 more source