Results 31 to 40 of about 11,342,017 (299)

A computational model of the DNA damage-induced IKK/ NF-κB pathway reveals a critical dependence on irradiation dose and PARP-1

iScience, 2023
Summary: The activation of IKK/NF-κB by genotoxic stress is a crucial process in the DNA damage response. Due to the anti-apoptotic impact of NF-κB, it can affect cell-fate decisions upon DNA damage and therefore interfere with tumor therapy-induced cell
Fabian Konrath, Michael Willenbrock, Dorothea Busse, Claus Scheidereit, Jana Wolf   +4 more
doaj   +1 more source

A model of yeast glycolysis based on a consistent kinetic characterisation of all its enzymes [PDF]

, 2013
peer reviewedWe present an experimental and computational pipeline for the generation of kinetic models of metabolism, and demonstrate its application to glycolysis in Saccharomyces cerevisiae. Starting from an approximate mathematical model, we employ a
Carroll, Kathleen M, Paton, Norman W, Mendes, Pedro, McCarthy, John E G, Carroll, K.M., Weichart, D., Broomhead, David S., Murabito, Ettore, Khan, Farid, Messiha, Hanan L.,, Dunn, Warwick B., Oliver, Stephen G,, Swainston, N., Broomhead, D. S., Dada, Joseph O., Oliver, Stephen G., Westerhoff, H.V.; id_orcid, Kell, Douglas B.,, Kell, D.B., Gaskell, Simon J, Winder, Catherine L., Malys, Naglis, Dada, J.O., Westerhoff, Hans V.,, Pir, P., Paton, N.W., Pendes, Pedro, Pir, Pınar,, Murabito, Ettore,, Messiha, H.L., Paton, Norman W., Westerhoff, Hans V., Gaskell, Simon J., Dunn, Warwick B.,, Simeonidis, E., Kell, Douglas B., Simeonidis, Evangelos,, Khan, Farid,, Jameson, Daniel; id_orcid, Gaskell, S.J., Jameson, Daniel, Dada, Joseph O, Carroll, Kathleen M.,, Spasić, I., Kell, Douglas B, Smallbone, K., Winder, Catherine L, Mendes, P., McCarthy, John E. G., Hayes, Neil W., Paton, Norman; id_orcid, Spasic, Irena, Weichart, Dieter, Pir, Pınar, Gaskell, S. J., Carroll, Kathleen M., Dunn, W.B., Jameson, Daniel,, Jameson, D., Gaskell, Simon J.,, Malys, N., Paton, Norman W.,, Malys, Naglis,, SIMEONIDIS, Vangelis, Smallbone, Kieran,, Simeonidis, Evangelos, Wishart, J., Messiha, Hanan L, Wishart, Jill,, Westerhoff, Hans V, McCarthy, John E G,, Murabito, E., Khan, F., Oliver, Stephen G, Wishart, Jill, Broomhead, David S, Messiha, Hanan L., Dunn, Warwick B, Winder, C.L., Jameson, D,, Dada, Joseph O.,, Swainston, Neil,, Weichart, Dieter,, Oliver, S. G., Hayes, N.W., Pir, Pinar, Spasić, Irena,, Broomhead, D.S., Mendes, Pedro,, Broomhead, David S.,, McCarthy, John E.G., Hayes, Neil W, Hayes, Neil W.,, Oliver, S.G., Swainston, Neil, Smallbone, Kieran, McCarthy, J.E.G., Winder, Catherine L.,, Westerhoff, H.V., Carroll, Kathleen M; id_orcid   +99 more
core   +2 more sources

A systems biology approach to multi-scale modelling and analysis of planar cell polarity in drosophila melanogaster wing [PDF]

, 2013
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Systems biology aims to describe and understand biology at a global scale where biological systems function as a result of complex mechanisms that happen at
Gao, Qian
core   +7 more sources

Curating the innate immunity interactome [PDF]

, 2010
peer-reviewedBackground: The innate immune response is the first line of defence against invading pathogens and is regulated by complex signalling and transcriptional networks.
Laird, Matthew R, Anastasia Sribnaia, Winsor, Geoffrey L., Lynn, David J, Giselle Ring, Foroushani, Amir K., Laird, Matthew R., Que, Jaimmie, Geoffrey L Winsor, Robert EW Hancock, Sribnaia, Anastasia, Hancock, Robert E.W., Ring, Giselle, Melissa Yau, Fiona SL Brinkman, Calvin Chan, Jaimmie Que, David J Lynn, Brinkman, Fiona S. L., Naseer, Misbah, Matthew R Laird, Yau, Melissa, Lo, Raymond, Raymond Lo, Chan, Calvin, Wee, Kathleen, Winsor, Geoffrey L, Breuer, Karin, Kathleen Wee, Amir K Foroushani, Hancock, R. E. W. (Robert E. W.), Brinkman, Fiona S., Misbah Naseer, Karin Breuer, Lynn, David J.   +34 more
core   +1 more source

Systems Biology as an Integrated Platform for Bioinformatics, Systems Synthetic Biology, and Systems Metabolic Engineering

Cells, 2013
Systems biology aims at achieving a system-level understanding of living organisms and applying this knowledge to various fields such as synthetic biology, metabolic engineering, and medicine. System-level understanding of living organisms can be derived
Bor-Sen Chen, Chia-Chou Wu
doaj   +1 more source

Editorial overview: Systems biology for biotechnology [PDF]

, 2017
About 15 years ago, systems biology was introduced as a novel approach to biological research. On the one side, its introduction was a result of the recognition that through solely the reductionist approach, we would ulti- mately not be able to ...
Yitzhak Pilpel, Heinemann, Matthias; id_orcid, Heinemann, Matthias, Pilpel, Yitzhak, Matthias Heinemann   +4 more
core   +2 more sources

Design considerations for representing systems biology information with the Systems Biology Graphical Notation

Journal of Integrative Bioinformatics, 2022
Visual representations are commonly used to explore, analyse, and communicate information and knowledge in systems biology and beyond. Such visualisations not only need to be accurate but should also be aesthetically pleasing and informative.
Schreiber Falk, Czauderna Tobias
doaj   +1 more source

Systems Biology for Biologists [PDF]

PLOS Pathogens, 2015
Rachel A Hillmer
openaire   +4 more sources

Systems Biology, Integrative Biology, Predictive Biology [PDF]

Cell, 2005
The pursuit of science is based on empiricism enabled by advancing technologies. Theories then emerge that unify our understanding of natural order. The trinity of experimentation, theory, and technology that underlies the scientific method cannot be placed into a hierarchy of importance.
openaire   +2 more sources

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source