Results 51 to 60 of about 11,342,017 (299)

Infant Embryonal CNS Tumors: Molecular Insights and Treatment Considerations for Contemporary Pediatric Neuro‐Oncology

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Embryonal tumors comprise the majority of malignant central nervous system (CNS) neoplasms diagnosed in children under 3 years of age. Compared with their counterparts in older children, these tumors exhibit distinct molecular biology and a more aggressive clinical phenotype, while their management is complicated by the heightened ...
Sudarshawn Damodharan, Mariah Wright‐Nadkarni, Mohamed S. Abdelbaki, Girish Dhall   +3 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

From systems biology to synthetic biology [PDF]

Molecular Systems Biology, 2005
Mol Syst Biol. 1: 2005.0032 If each of us conveys our idiosyncratic view of the elephant, then we, in communion, can imagine its wholeness (Ireland, 1997). An analogous process elucidates Molecular Systems Biology (MSB) and this journal is dedicated to it. The work of a scientist/engineer (seer for short) consists of discovery, modeling, perturbation,
openaire   +4 more sources

Application of Gene Shaving and Mixture Models to Cluster Microarray Gene Expression Data

Cancer Informatics, 2007
Researchers are frequently faced with the analysis of microarray data of a relatively large number of genes using a small number of tissue samples. We examine the application of two statistical methods for clustering such microarray expression data ...
S. Wen, R. Bean, G.J. McLachlan, K-A. Do
doaj  

Logical and experimental modeling of cytokine and eicosanoid signaling in psoriatic keratinocytes

iScience, 2021
Summary: Psoriasis is a chronic skin disease, in which immune cells and keratinocytes keep each other in a state of inflammation. It is believed that phospholipase A2 (PLA2)-dependent eicosanoid release plays a key role in this.
Eirini Tsirvouli, Felicity Ashcroft, Berit Johansen, Martin Kuiper   +3 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Systems biology versus molecular biology [PDF]

Current Biology, 2004
Molecular biology and systems biology provide answers to the same questions, but the answers are quite different for the two approaches and are, on the surface, unrelated. The molecular biological answers are arguably more fundamental and are unique, but alternative systems biology answers are possible – consider the two systems-level answers to the ...
openaire   +2 more sources

A consensus yeast metabolic network reconstruction obtained from a community approach to systems biology [PDF]

, 2008
Genomic data allow the large-scale manual or semi-automated assembly of metabolic network reconstructions, which provide highly curated organism-specific knowledge bases.
Mendes, Pedro, Arga, K. Yalçin,, Weichart, D., Broomhead, David S., Merja Penttilä, Dunn, Warwick B., Swainston, N., Stephen G Oliver, Oliver, Stephen G., Arvas, M., Westerhoff, H.V.; id_orcid, Borger, Simon, Dieter Weichart, Kell, Douglas B.,, Le Novère, Nicolas, Kell, D.B., Nils Blüthgen, Paton, N., Monica L Mo, Mo, M., Herrgård, Markus J.,, Penttilä, Merja,, Kırdar, Betül, Kirdar, B., Kırdar, Bet\ufcl, Herrgård, M., Westerhoff, Hans V.,, Costenoble, R., Kieran Smallbone, Nielsen, Jens,, K Yalçin Arga, Palsson, Bernhard Ø, Liebermeister, Wolfram, Sauer, Uwe, Dunn, W., Palsson, Bernhard Ø.,, Petranovic Nielsen, Dina, Nielsen, Jens B., Westerhoff, Hans V., Roeland Costenoble, Penttila, M., Markus J Herrgård, Brent, Roger,, Dunn, Warwick B.,, Nielsen, J., Nielsen, Jens B, Kell, D., Spasić, Irena, Pettifer, Stephen,, Simeonidis, E., Liebermeister, Wolfram,, Kell, Douglas B., Sauer, Uwe,, Mo, Monica L., Palsson, B.Ø., Palsson, Bernhard 8, Simeonidis, Evangelos,, Arvas, Mikko,, Irena Spasié, Mo, Monica L.,, Kirdar, Betül, Petranovic, D., Herrgard, Markus, Spasi, I., Kell, Douglas B, Spasić, I., Bernhard Ø Palsson, Pettifer, S., Büthgen, Nils, Smallbone, K., Liebermeister, W., Costenoble, Roeland,, Brent, R., Mendes, P., Le Nov\ue8re, Nicolas, Michael Hucka, Büthgen, N., Matthias Heinemann, Evangelos Simeonidis, Li, Peter,, Mikko Arvas, Blüthgen, Nils, Weichart, Dieter, Dobson, Paul, Klipp, Edda,, Pettifer, Stephen, Arga, K.Y., Le Novère, N., Kırdar, Betül,, Dunn, W.B., Paul Dobson, Jens Nielsen, Roger Brent, Neil Swainston, Borger, S., Oliveira, A., Spasié, Irena, Palsson, B., Hucka, M., Wolfram Liebermeister, Smallbone, Kieran,, Herrg\ue5rd, Markus J, Simeonidis, Evangelos, Penttilä, Merja, Oliver, Stephen G.,, Westerhoff, H., Petranovic, Dina, Oliveira, A.P., Simeonides, E., Uwe Sauer, Palsson, Bernhard Ø., Westerhoff, Hans V, Broomhead, D., Pedro Mendes, David S Broomhead, Heinemann, M., Oliver, Stephen G, Westerhoff, Hans W, Novère, Nicolas Le, Borger, Simon,, Dina Petranovic, Arvas, Mikko, Blüthgen, Nils,, Broomhead, David S, Dobson, P., Peter Li, Costenoble, E.R., Dunn, Warwick B, Klipp, Edda, Stephen Pettifer, Arga, K Yalçin, Hucka, Michael, Mo, Minica L., Li, P, Weichart, Dieter,, Swainston, Neil,, Mo, Monica L, Warwick B Dunn, Edda Klipp, Arga, K., Kürdar, Betül, Ana Paula Oliveira, Bl\ufcthgen, Nils, Simon Borger, Spasić, Irena,, Costenoble, Roeland, Arga, K Yal\ue7in, Li, Peter, Broomhead, D.S., Kırdar, B.I., Sauer, U., Oliveira, Ana Paula,, Heinemann, Matthias,, Nielsen, Jens, Klipp, E., Betül Kürdar, Mo, M.L., Heinemann, Matthias; id_orcid, Mendes, Pedro,, Hans V Westerhoff, Broomhead, David S.,, Novère, Nicolas Le,, Dobson, Paul,, Douglas B Kell, Spasié, I., Penttilä, Merja; id_orcid, Oliver, S.G., Swainston, Neil, Soberano de Oliveira, Ana Paula, Penttil\ue4, Merja, Li, P., Kürdar, B., Palsson, B.O., Smallbone, Kieran, Petranovic, Dina,, Heinemann, Matthias, Oliver, S., Palsson, Bernhard, Herrgard, M.J., Arga, K. Yalçin, Westerhoff, H.V., Hucka, Michael,, Herrgård, Markus J, Bluthgen, N., Oliveira, Ana Paula, Coestenoble, Roeland, Brent, Roger, Westerhoff, Hans V.; id_orcid, Herrgård, Markus J., Nicolas Le Novère, Palsson, Bernhard O.   +190 more
core   +3 more sources

Advancing Cancer Systems Biology: Introducing the Center for the Development of a Virtual Tumor, CViT

Cancer Informatics, 2007
Integrative cancer biology research relies on a variety of data-driven computational modeling and simulation methods and techniques geared towards gaining new insights into the complexity of biological processes that are of critical importance for cancer
Sean Martin, Le Zhang, Thomas S. Deisboeck   +2 more
doaj  

Tumor microenvironment mimicking 3D models unveil the multifaceted effects of SMAC mimetics

iScience, 2023
Summary: Small molecule IAP antagonists - SMAC mimetics (SM) - are being developed as an anticancer therapy. SM therapy was demonstrated not only to sensitize tumor cells to TNFα-mediated cell death but also to exert immunostimulatory properties.
Catarina Pinto, Ksenija Slavic-Obradovic, Daniela Fürweger, Barbara Thaler, Abdallah Souabni, Sebastian Carotta, Martin Aichinger, Ulrich Reiser, Maria Antonietta Impagnatiello, Iñigo Tirapu   +9 more
doaj   +1 more source