Results 61 to 70 of about 2,985,376 (297)
From systems biology to synthetic biology [PDF]
Molecular Systems Biology, 2005 Mol Syst Biol. 1: 2005.0032 If each of us conveys our idiosyncratic view of the elephant, then we, in communion, can imagine its wholeness (Ireland, 1997). An analogous process elucidates Molecular Systems Biology (MSB) and this journal is dedicated to it. The work of a scientist/engineer (seer for short) consists of discovery, modeling, perturbation,
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Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report
Pediatric Blood &Cancer, EarlyView.ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan +6 more
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Application of Gene Shaving and Mixture Models to Cluster Microarray Gene Expression Data
Cancer Informatics, 2007 Researchers are frequently faced with the analysis of microarray data of a relatively large number of genes using a small number of tissue samples. We examine the application of two statistical methods for clustering such microarray expression data ...
S. Wen, R. Bean, G.J. McLachlan, K-A. Do
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Cloning of DNA oligo pools for in vitro expression
STAR Protocols, 2022 Summary: Oligo library pools are powerful tools for systematic investigation of genetic and transcriptomic machinery such as promoter function and gene regulation, non-coding RNAs, or RNA modifications.
Anna Uzonyi, Ronit Nir, Schraga Schwartz
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Systems Biology and Pangenome of Salmonella O-Antigens. [PDF]
, 2019 O-antigens are glycopolymers in lipopolysaccharides expressed on the cell surface of Gram-negative bacteria. Variability in the O-antigen structure constitutes the basis for the establishment of the serotyping schema. We pursued a two-pronged approach to
Kavvas, Erol +4 more
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Systems biology versus molecular biology [PDF]
Current Biology, 2004 Molecular biology and systems biology provide answers to the same questions, but the answers are quite different for the two approaches and are, on the surface, unrelated. The molecular biological answers are arguably more fundamental and are unique, but alternative systems biology answers are possible – consider the two systems-level answers to the ...
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Pediatric Blood &Cancer, EarlyView.ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song +15 more
wiley +1 more source
Perturbation of Interaction Networks for Application to Cancer Therapy
Cancer Informatics, 2007 We present a computational approach for studying the effect of potential drug combinations on the protein networks associated with tumor cells.
Steven J. M. Jones +2 more
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EcoCyc: fusing model organism databases with systems biology. [PDF]
, 2012 EcoCyc (http://EcoCyc.org) is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of individual E.
Bonavides-Martínez, César +23 more
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Biophysics and systems biology [PDF]
Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2010 Biophysics at the systems level, as distinct from molecular biophysics, acquired its most famous paradigm in the work of Hodgkin and Huxley, who integrated their equations for the nerve impulse in 1952. Their approach has since been extended to other organs of the body, notably including the heart. The modern field of computational biology has expanded
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