Results 81 to 90 of about 12,579,596 (265)
, 2017 Week 7: Systems Biology and Big Data 7.2 Systems Biology Systems Biology and Data Analysis DemoDemystifying Biomedical Big Data BIOX-201 ...
Haddad, Bassem +2 more
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, 2020 Twenty years ago, the term ‘Systems Biology’ has been coined, after which Institutes of Systems Biology were established in Tokyo, Seattle and Amsterdam by the pioneers Hiroaki Kitano, Leroy Hood, and Hans Westerhoff, respectively. For their achievements,
Barberis, Matteo, Klipp, E.
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Advancing Systems Biology in the International Conference on Intelligent Biology and Medicine (ICIBM) 2015 [PDF]
, 2016 The 2015 International Conference on Intelligent Biology and Medicine (ICIBM 2015) was held on November 13-15, 2015 in Indianapolis, Indiana, USA. ICIBM 2015 included eight scientific sessions, three tutorial sessions, one poster session, and four ...
Liu, Yunlong +4 more
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From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
, 2017 Week 7: Systems Biology and Big Data 7.2 Systems Biology Systems Biology Lecture Part 1Demystifying Biomedical Big Data BIOX-201 ...
Haddad, Bassem +2 more
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Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Handbook of Systems Biology: Concepts and Insights
, 2013 A partial preview of this book is available via Google Books.Publisher's description: This book provides an entry point into Systems Biology for researchers in genetics, molecular biology, cell biology, microbiology and biomedical science to understand ...
Dekker, Job +2 more
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