Results 71 to 80 of about 11,342,017 (299)

Metabolomic systems biology of trypanosomes [PDF]

, 2010
Metabolomics analysis, which aims at the systematic identification and quantification of all metabolites in biological systems, is emerging as a powerful new tool to identify biomarkers of disease, report on cellular responses to environmental ...
Barrett, M.P., Michael P. Barrett, Breitling, Rainer, Breitling, R., Breitling, Rainer,, Bakker, Barbara M.; id_orcid, Rainer Breitling, Barbara M. Bakker, Barrett, Michael P., Bakker, Barbara M.,, Bakker, B.M., Barrett, Michael P.,, Bakker, Barbara M.   +12 more
core   +2 more sources

Deciphering sphingolipid biosynthesis dynamics in Arabidopsis thaliana cell cultures: Quantitative analysis amid data variability

iScience
Summary: Sphingolipids are pivotal for plant development and stress responses. Growing interest has been directed toward fully comprehending the regulatory mechanisms of the sphingolipid pathway.
Abraham Osinuga, Ariadna González Solís, Rebecca E. Cahoon, Adil Alsiyabi, Edgar B. Cahoon, Rajib Saha   +5 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Functional Genomics, Proteomics, Metabolomics and Bioinformatics for Systems Biology [PDF]

, 2013
peer reviewedThis chapter introduces systems biology, its context, aims, concepts and strategies. It then describes approaches and methods used for collection of high-dimensional structural and functional genomics data, including epigenomics ...
Nitin Baliga, Reinhard Schneider, KOLODKIN, Alexey, Nikos Vlassis, Ballereau, S., SCHNEIDER, Reinhard, VLASSIS, Nikos, GLAAB, Enrico, Hassan Ahmed, Charles Auffray, Amphun Chaiboonchoe, Johann Pellet, Leroy Hood, Enrico Glaab, HOOD, Leroy, BIRYUKOV, Maria, Stéphane Ballereau, Ahmed, H., BALLING, Rudi, Rudi Balling, Baliga, N., Alexei Kolodkin, Auffray, C., Chaiboonchoe, A., Pellet, J., Maria Biryukov   +25 more
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Biophysics and systems biology [PDF]

Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 2010
Biophysics at the systems level, as distinct from molecular biophysics, acquired its most famous paradigm in the work of Hodgkin and Huxley, who integrated their equations for the nerve impulse in 1952. Their approach has since been extended to other organs of the body, notably including the heart. The modern field of computational biology has expanded
openaire   +2 more sources

Computational and Systems Biology [PDF]

Molecular BioSystems, 2009
M. Madan Babu and Hirotada Mori introduce this themed issue of Molecular BioSystems focusing on Computational and systems biology
M Madan, Babu, Hirotada, Mori
openaire   +2 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source