Results 211 to 220 of about 1,188,505 (261)

Evaluation of genes and molecular pathways involved in ferroptosis in breast cancer: A systems biology and bioinformatics approach. [PDF]

Biochem Biophys Rep
Heydari A, Yaghmoorian Khojini J, Hayati MJ, Khara F, Abootorabi SMS, Manoochehri H, Mousavi MJ.   +6 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Artificial intelligence and systems biology analysis in stem cell research and therapeutics development. [PDF]

Stem Cells Transl Med
Silva-Sousa T, Nakanishi Usuda J, Al-Arawe N, Hinterseher I, Catar R, Luecht C, Vallecillo Garcia P, Riesner K, Hackel A, Schimke LF, Dutra Dias H, Salerno Filgueiras I, Nakaya HI, Camara NOS, Fischer S, Riemekasten G, Ringdén O, Penack O, Winkler T, Duda G, Fonseca DLM, Cabral-Marques O, Moll G.   +22 more
europepmc   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

A Systems Biology and Drug Repositioning Approach for the Analysis of Mutual Genes Between Celiac Disease and Irritable Bowel Syndrome. [PDF]

Biomed Res Int
Al-Madhagi H.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

SBMLtoOdin and Menelmacar: interactive visualisation of systems biology models for expert and non-expert audiences. [PDF]

Bioinformatics
Lorenz LJ, Andréoletti A, Nguyen TVN, Hermjakob H, FitzJohn RG, Malik Sheriff RS, Lees JA.   +6 more
europepmc   +1 more source

Synergistic effects of vedolizumab and JAK 1,2,3 inhibitors in Crohn's disease: insights from a systems biology and artificial intelligence-based approach. [PDF]

Front Immunol
Marín-Jiménez I, Sierra-Ausín M, Letosa-Abián T, Aparicio J, Montoto-Otero C, Sánchez-Ramón S.   +5 more
europepmc   +1 more source

A systems biology approach to understand temporal evolution of silver nanoparticle toxicity. [PDF]

NPJ Syst Biol Appl
Park SG, Lee E, Kim HY, Yoon TH.
europepmc   +1 more source

Reconciling multiple connectivity-based systems biology methods for drug repurposing. [PDF]

Brief Bioinform
Gonzalez Gomez C, Rosa-Calatrava M, Fouret J.   +2 more
europepmc   +1 more source