Results 211 to 220 of about 2,957,126 (345)

Challenges and opportunities in systems biology education. [PDF]

Endocr Relat Cancer
Didier J, Croce S, Bayoumi S, Valceschini E, Escoffier H, Gonzalez E, Kishk A, Badkas A, De Landtsheer S, Sauter T.   +9 more
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Cancer as a System Failure

Cancer Informatics, 2007
Igor Jurisica, Dennis Wigle
doaj  

Transcriptomic signatures in Gaucher disease subtypes: A systems biology perspective. [PDF]

Mol Genet Metab Rep
Elahimanesh M, Ganjali R, Najafi M.
europepmc   +1 more source

Computational development of regulatory gene set networks for systems biology applications

, 2014
Chayaporn Suphavilai
openalex   +1 more source

Respiratory system: A learning content development system-based student worksheet in biology

, 2021
Andi Thahır, Gustina Gustina, Yetri Yetri, Siti Zahra Bulantika, Permata Sari, Rubi Rimonda, Tri Dewantari   +6 more
openalex   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Systems biology successes and areas for opportunity in prostate cancer. [PDF]

Endocr Relat Cancer
Orman MV, Graham LS, Cramer SD, Costello JC.   +3 more
europepmc   +1 more source

Floral Biology and Breeding System of Garcinia Imberti Bourd.-A Critically Endangered Tree Species of Western Ghats, Kerala, India [PDF]

, 2015
R. Kandasamy, Keshavanarayan Puttaramaiah, Shubharani Ramnath, Sivaramvenkataramgowda   +3 more
openalex  

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source