Results 21 to 30 of about 1,150,837 (304)
A yeast chemogenomic screen identifies pathways that modulate adipic acid toxicity
iScience, 2021 Summary: Adipic acid production by yeast fermentation is gaining attention as a renewable source of platform chemicals for making nylon products. However, adipic acid toxicity inhibits yeast growth and fermentation.
Eugene Fletcher +3 more
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STAR Protocols, 2023 Summary: RNA-binding proteins (RBPs) can bind and mediate RNA-RNA contacts. However, identifying specific RBP-organized RNA-RNA contacts remains challenging.
Rong Ye, Naijing Hu, Yuanchao Xue
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Integrative biology and systems biology [PDF]
Molecular Systems Biology, 2005 Mol Syst Biol. 1: 2005.0004 Demarcations of scientific fields have always followed either a conceptual breakthrough or have been a result of profoundly enabling technologies. Quantum theory and quantum mechanics revolutionized physics and engineering, but high‐energy physics is a discipline fundamentally enabled by the linear accelerator.
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Systems Biology in Periodontitis
Frontiers in Dental Medicine, 2022 Systems biology is a promising scientific discipline that allows an integrated investigation of host factors, microbial composition, biomarkers, immune response and inflammatory mediators in many conditions such as chronic diseases, cancer, neurological ...
Davi Neto de Araújo Silva +2 more
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Stratification of patients with clear cell renal cell carcinoma to facilitate drug repositioning
iScience, 2021 Summary: Clear cell renal cell carcinoma (ccRCC) is the most common histological type of kidney cancer and has high heterogeneity. Stratification of ccRCC is important since distinct subtypes differ in prognosis and treatment.
Xiangyu Li +12 more
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iScience, 2023 Summary: The activation of IKK/NF-κB by genotoxic stress is a crucial process in the DNA damage response. Due to the anti-apoptotic impact of NF-κB, it can affect cell-fate decisions upon DNA damage and therefore interfere with tumor therapy-induced cell
Fabian Konrath +4 more
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Clinical Pharmacology & Therapeutics, 2010 In just over a decade, Systems Biology has moved from being an idea, or rather a disparate set of ideas, to a mainstream feature of research and funding priorities. Institutes, departments, and centers of various flavors of Systems Biology have sprung up all over the world. An Internet search now produces more than 2 million hits.
Kohl P. +3 more
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iScience, 2021 Summary: Genomic data can facilitate personalized treatment decisions by enabling therapeutic hypotheses in individual patients. Mutual exclusivity has been an empirically useful signal for identifying activating mutations that respond to single agent ...
Haider Inam +8 more
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Molecular Systems Biology, 2006 Genome-scale networks can now be reconstructed based on high-throughput data sets. Mathematical analyses of these networks are used to compute their candidate functional or phenotypic states. Analysis of functional states of networks shows that the activity of biochemical reactions can be highly correlated in physiological states, forming so-called co ...
Jamshidi, Neema, Palsson, Bernhard Ø
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Imaging in Systems Biology [PDF]
Cell, 2007 Most systems biology approaches involve determining the structure of biological circuits using genomewide "-omic" analyses. Yet imaging offers the unique advantage of watching biological circuits function over time at single-cell resolution in the intact animal.
Megason, Sean G., Fraser, Scott E.
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