Results 21 to 30 of about 3,348,134 (351)

Systems Biology in Periodontitis

Frontiers in Dental Medicine, 2022
Systems biology is a promising scientific discipline that allows an integrated investigation of host factors, microbial composition, biomarkers, immune response and inflammatory mediators in many conditions such as chronic diseases, cancer, neurological ...
Davi Neto de Araújo Silva, Sepehr Monajemzadeh, Flavia Queiroz Pirih   +2 more
doaj   +1 more source

Systems biologists seek fuller integration of systems biology approaches in new cancer research programs [PDF]

, 2010
Systems biology takes an interdisciplinary approach to the systematic study of complex interactions in biological systems. This approach seeks to decipher the emergent behaviors of complex systems rather than focusing only on their constituent properties.
Auffray, C, Baltrusch, S, Bluthgen, N, Byrne, H. M., Cascante, M, Ciliberto, A, Dale, T, Drasdo, D, Fell, D, Ferrell, J, Gallahan, D, Gatenby, R. A., Guenther, U, Harms, B, Herzel, H., Jaster, R, Junghanss, C, Kunz, M, Laplace, F, Lenormand, P, Levi, F, Linnebacher, M, Lowengrub, J, Maini, P. K., Malik, A, Marcus, F, Rateitschak, K, Sansom, O, Schafer, R, Schnell, S., Schurrle, K, Sers, C, Shibata, D, Tyson, J, van Leeuwen, I. M. M., Vera, J, White, M, Wolkenhauer, O, Zhivotovsky, B   +38 more
core   +1 more source

Pioneer factors in development and cancer

iScience, 2021
Summary: Transcription factors (TFs) are essential mediators of epigenetic regulation and modifiers of penetrance. Studies from the past decades have revealed a sub-class of TF that is capable of remodeling closed chromatin states through targeting ...
Benjamin D. Sunkel, Benjamin Z. Stanton
doaj  

An oscillating reaction network with an exact closed form solution in the time domain

BMC Bioinformatics, 2023
Background Oscillatory behavior is critical to many life sustaining processes such as cell cycles, circadian rhythms, and notch signaling. Important biological functions depend on the characteristics of these oscillations (hereafter, oscillation ...
Joseph Hellerstein
doaj   +1 more source

Enhanced Operational Semantics in Systems Biology [PDF]

, 2003
We are faced with a great challenge: the cross-fertilization between the fields of formal methods for concurrency, in the computer science domain, and systems biology in the biological ...
A. Dovier, E.M. Clarke, H. Jong, M. Elowitz, O. Müller, P.D. Karp, P.D. Karp, R. Alur, R. Alur, R. Paige, R.W. Brockett, T.A. Henzinger   +11 more
core   +1 more source

A persistent invasive phenotype in post-hypoxic tumor cells is revealed by fate mapping and computational modeling

iScience, 2021
Summary: Hypoxia is a critical factor in solid tumors that has been associated with cancer progression and aggressiveness. We recently developed a hypoxia fate mapping system to trace post-hypoxic cells within a tumor for the first time.
Heber L. Rocha, Inês Godet, Furkan Kurtoglu, John Metzcar, Kali Konstantinopoulos, Soumitra Bhoyar, Daniele M. Gilkes, Paul Macklin   +7 more
doaj  

Mechanical and Systems Biology of Cancer [PDF]

, 2018
Mechanics and biochemical signaling are both often deregulated in cancer, leading to cancer cell phenotypes that exhibit increased invasiveness, proliferation, and survival.
Bakal, Chris, Mak, Michael, Spill, Fabian   +2 more
core   +3 more sources

SBML models and MathSBML [PDF]

, 2008
MathSBML is an open-source, freely-downloadable Mathematica package that facilitates working with Systems Biology Markup Language (SBML) models. SBML is a toolneutral,computer-readable format for representing models of biochemical reaction networks ...
Shapiro, B.E., Finney, A., Hucka, M., Bornstein, B., Funahashi, A., Jouraku, A., Keating, S., Le Novere, N., Matthews, J., Schilstra, M.   +9 more
core   +6 more sources

Systems biology in inflammatory bowel diseases [PDF]

, 2014
Purpose of review: Ulcerative colitis (UC) and Crohn’s Disease (CD) are the two predominant types of inflammatory bowel disease (IBD), affecting over 1.4 million individuals in the US.
Iliopoulos, D, Koukos, G, Polytarchou, C
core   +1 more source

Systems Biology, Integrative Biology, Predictive Biology [PDF]

Cell, 2005
The pursuit of science is based on empiricism enabled by advancing technologies. Theories then emerge that unify our understanding of natural order. The trinity of experimentation, theory, and technology that underlies the scientific method cannot be placed into a hierarchy of importance.
openaire   +3 more sources