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Bioinform., 2003 MOTIVATION Molecular biotechnology now makes it possible to build elaborate systems models, but the systems biology community needs information standards if models are to be shared, evaluated and developed cooperatively.
M. Hucka +42 more
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Formal Systems Architectures for Biology [PDF]
, 2011 When the word "systems" is used in systems biology, it invokes a variety of assumptions about what defines the subject under investigation, which in turn can lead to divergent research outcomes.
Bradly Alicea
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Human organoids: model systems for human biology and medicine
Nature reviews. Molecular cell biology, 2020 The historical reliance of biological research on the use of animal models has sometimes made it challenging to address questions that are specific to the understanding of human biology and disease. But with the advent of human organoids — which are stem
Jihoon Kim, B. Koo, J. Knoblich
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Computational inference in systems biology [PDF]
, 2015 Parameter inference in mathematical models of biological pathways, expressed as coupled ordinary differential equations (ODEs), is a challenging problem. The computational costs associated with repeatedly solving the ODEs are often high.
A. Lotka +9 more
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Integrative biology and systems biology [PDF]
Molecular Systems Biology, 2005 Mol Syst Biol. 1: 2005.0004 Demarcations of scientific fields have always followed either a conceptual breakthrough or have been a result of profoundly enabling technologies. Quantum theory and quantum mechanics revolutionized physics and engineering, but high‐energy physics is a discipline fundamentally enabled by the linear accelerator.
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Systems biology in inflammatory bowel diseases [PDF]
, 2014 Purpose of review: Ulcerative colitis (UC) and Crohn’s Disease (CD) are the two predominant types of inflammatory bowel disease (IBD), affecting over 1.4 million individuals in the US.
Iliopoulos, D, Koukos, G, Polytarchou, C
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Borges Dilemma, Fundamental Laws, and Systems Biology [PDF]
, 2007 I reason here that the known folk law in biology that there is no general law in biology because of exceptions is false. The (quantitative) systems biology offers the potential to solve the Borges Dilemma, by transcending it.
Ao, P
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KBase: The United States Department of Energy Systems Biology Knowledgebase
Nature Biotechnology, 2018 Author(s): Arkin, Adam P; Cottingham, Robert W; Henry, Christopher S; Harris, Nomi L; Stevens, Rick L; Maslov, Sergei; Dehal, Paramvir; Ware, Doreen; Perez, Fernando; Canon, Shane; Sneddon, Michael W; Henderson, Matthew L; Riehl, William J; Murphy-Olson,
A. Arkin +80 more
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Enhanced Operational Semantics in Systems Biology [PDF]
, 2003 We are faced with a great challenge: the cross-fertilization between the fields of formal methods for concurrency, in the computer science domain, and systems biology in the biological ...
A. Dovier +11 more
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Clinical Pharmacology & Therapeutics, 2010 In just over a decade, Systems Biology has moved from being an idea, or rather a disparate set of ideas, to a mainstream feature of research and funding priorities. Institutes, departments, and centers of various flavors of Systems Biology have sprung up all over the world. An Internet search now produces more than 2 million hits.
Kohl P. +3 more
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