Results 71 to 80 of about 2,989,026 (346)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Application of Gene Shaving and Mixture Models to Cluster Microarray Gene Expression Data
Cancer Informatics, 2007 Researchers are frequently faced with the analysis of microarray data of a relatively large number of genes using a small number of tissue samples. We examine the application of two statistical methods for clustering such microarray expression data ...
S. Wen, R. Bean, G.J. McLachlan, K-A. Do
doaj
Identification of VIMP as a gene inhibiting cytokine production in human CD4+ effector T cells
iScience, 2021 Summary: Many players regulating the CD4+ T cell-mediated inflammatory response have already been identified. However, the critical nodes that constitute the regulatory and signaling networks underlying CD4 T cell responses are still missing.
Christophe M. Capelle +6 more
doaj +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Perturbation of Interaction Networks for Application to Cancer Therapy
Cancer Informatics, 2007 We present a computational approach for studying the effect of potential drug combinations on the protein networks associated with tumor cells.
Steven J. M. Jones +2 more
doaj
EcoCyc: fusing model organism databases with systems biology. [PDF]
, 2012 EcoCyc (http://EcoCyc.org) is a model organism database built on the genome sequence of Escherichia coli K-12 MG1655. Expert manual curation of the functions of individual E.
Bonavides-Martínez, César +23 more
core +1 more source
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Cancer Informatics, 2007 The biological interpretation of gene expression microarray results is a daunting challenge. For complex diseases such as cancer, wherein the body of published research is extensive, the incorporation of expert knowledge provides a useful analytical ...
Jason H. Moore +2 more
doaj
Cloning of DNA oligo pools for in vitro expression
STAR Protocols, 2022 Summary: Oligo library pools are powerful tools for systematic investigation of genetic and transcriptomic machinery such as promoter function and gene regulation, non-coding RNAs, or RNA modifications.
Anna Uzonyi, Ronit Nir, Schraga Schwartz
doaj +1 more source
Metabolic systems biology [PDF]
FEBS Letters, 2009 The first full genome sequences were established in the mid‐1990s. Shortly thereafter, genome‐scale metabolic network reconstructions appeared. Since that time, we have witnessed an exponential growth in their number and uses. Here I discuss, from a personal point of view, four topics: (1) the placement of metabolic systems biology in the context of ...
openaire +2 more sources