Results 81 to 90 of about 25,508,313 (370)
The Meaning of Systems Biology [PDF]
Cell, 2005 With the new excitement about systems biology, there is understandable interest in a definition. This has proven somewhat difficult. Scientific fields, like species, arise by descent with modification, so in their earliest forms even the founders of great dynasties are only marginally different than their sister fields and species.
openaire +3 more sources
Perturbation of Interaction Networks for Application to Cancer Therapy
Cancer Informatics, 2007 We present a computational approach for studying the effect of potential drug combinations on the protein networks associated with tumor cells.
Steven J. M. Jones +2 more
doaj
iScience, 2021 Summary: Genomic data can facilitate personalized treatment decisions by enabling therapeutic hypotheses in individual patients. Mutual exclusivity has been an empirically useful signal for identifying activating mutations that respond to single agent ...
Haider Inam +8 more
doaj
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Systems chemical biology [PDF]
Nature Chemical Biology, 2007 The increasing availability of data related to genes, proteins and their modulation by small molecules has provided a vast amount of biological information leading to the emergence of systems biology and the broad use of simulation tools for data analysis.
Oprea, Tudor I +3 more
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Cancer Informatics, 2007 The biological interpretation of gene expression microarray results is a daunting challenge. For complex diseases such as cancer, wherein the body of published research is extensive, the incorporation of expert knowledge provides a useful analytical ...
Jason H. Moore +2 more
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Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Journal of Cell Biology, 2014 Systems cell biology melds high-throughput experimentation with quantitative analysis and modeling to understand many critical processes that contribute to cellular organization and dynamics. Recently, there have been several advances in technology and in the application of modeling approaches that enable the exploration of the dynamic properties of ...
John D. Aitchison +4 more
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Developmental Systems Theory as a Process Theory [PDF]
, 2018 Griffiths and Russell D. Gray (1994, 1997, 2001) have argued that the fundamental unit of analysis in developmental systems theory should be a process – the life cycle – and not a set of developmental resources and interactions between those resources ...
Griffiths, Paul Edmund, Stotz, Karola
core
StochKit-FF: Efficient Systems Biology on Multicore Architectures [PDF]
, 2010 The stochastic modelling of biological systems is an informative, and in some cases, very adequate technique, which may however result in being more expensive than other modelling approaches, such as differential equations.
A. Perelson +7 more
core +2 more sources