Results 71 to 80 of about 1,058,962 (296)
Applying Systems Thinking to Engineering and Design
Systems, 2018 The application of Systems Thinking principles to Systems Engineering is synergistic, resulting in superior systems, products, and designs. However, there is little practical information available in the literature that describes how this can be done. In
Jamie P. Monat, Thomas F. Gannon
doaj +1 more source
Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids
Molecular Oncology, EarlyView.This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici +8 more
wiley +1 more source
Risk Analysis of Artificial Intelligence in Medicine with a Multilayer Concept of System Order
SystemsArtificial intelligence (AI) is advancing across technology domains including healthcare, commerce, the economy, the environment, cybersecurity, transportation, etc. AI will transform healthcare systems, bringing profound changes to diagnosis, treatment,
Negin Moghadasi +7 more
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Development of an automated guided vehicle controller using a systems engineering approach
South African Journal of Industrial Engineering, 2016 Automated guided vehicles (AGVs) are widely used for transporting materials in industry and commerce. In this research, an intelligent AGV-based material-handling system was developed using a model- based systems engineering (MBSE) approach.
Ferreira, Tremaine, Gorlach, Igor
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Other titles from iSTE in Systems and Industrial Engineering – Robotics [PDF]
, 2017 Aubry Jean-François +10 more
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A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression
Molecular Oncology, EarlyView.Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak +8 more
wiley +1 more source
A Case-Study-Based Comparative Evaluation of Functional Analysis Paradigms in Aircraft System Design
Applied SciencesFunctional analysis plays a critical role in early-stage aircraft system design by defining system functions that guide downstream architectural development and verification.
Haomin Li +3 more
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Embedded Master’s Students Conduct Highly Relevant Research Using Industry as Their Laboratory
Technology Innovation Management Review, 2019 This article analyzes participatory action research conducted by Systems Engineering master’s students embedded fifty percent in industrial companies for three years.
Kristin Falk, Gerrit Muller
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Molecular Oncology, EarlyView.Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande +11 more
wiley +1 more source
Aggressive prostate cancer is associated with pericyte dysfunction
Molecular Oncology, EarlyView.Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero +11 more
wiley +1 more source