Results 71 to 80 of about 25,134,561 (338)
Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer
FEBS Letters, EarlyView.Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani +4 more
wiley +1 more source
Applying Systems Thinking to Engineering and Design
Systems, 2018 The application of Systems Thinking principles to Systems Engineering is synergistic, resulting in superior systems, products, and designs. However, there is little practical information available in the literature that describes how this can be done. In
Jamie P. Monat, Thomas F. Gannon
doaj +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
A Systems Engineering Approach to Physical Security of Oil & Gas Installations
International Journal of Coastal and Offshore Engineering, 2019 A fundamental challenge facing security professionals is preventing loss; be that asset, production, or third-party losses. This is not dissimilar to what safety professionals have to face.
Sirous Yasseri
doaj
Development of an automated guided vehicle controller using a systems engineering approach
South African Journal of Industrial Engineering, 2016 Automated guided vehicles (AGVs) are widely used for transporting materials in industry and commerce. In this research, an intelligent AGV-based material-handling system was developed using a model- based systems engineering (MBSE) approach.
Ferreira, Tremaine, Gorlach, Igor
doaj +1 more source
FEBS Letters, EarlyView.Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley +1 more source
Embedded Master’s Students Conduct Highly Relevant Research Using Industry as Their Laboratory
Technology Innovation Management Review, 2019 This article analyzes participatory action research conducted by Systems Engineering master’s students embedded fifty percent in industrial companies for three years.
Kristin Falk, Gerrit Muller
doaj +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Semantic Priority Navigation for Energy-Aware Mining Robots
SystemsAutonomous navigation in subterranean mines is hindered by deformable terrain, dust-laden visibility, and densely packed, safety-critical machinery. We propose a systems-oriented navigation framework that embeds semantic priorities into reactive planning
Claudio Urrea +2 more
doaj +1 more source